5 terminated, 4 completed, 3 recruiting, 3 unknown. 17 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 17 | Terminated 5, Completed 4, Recruiting 3, Unknown 3, Active not recruiting 1, Withdrawn 1 |
Follow Corneal Opacity: new trials by email Literature Review of Corneal Opacity trials Research Report on Corneal Opacity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Losartan for Corneal Fibrosis Topical losartan, Placebo Control - Corneal Scarring Fibrosis | Not applicable | Recruiting | Universidad Autonoma de Nuevo Leon | 46 | 2026-02-12 | 2026-05-08 |
| PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated - Keratoconus | Not applicable | Recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 50 | 2025-09-01 | 2026-01-28 |
| Clinical Outcomes of the Gore Synthetic Cornea Device GORE Synthetic Cornea Device - Corneal Opacity | Not applicable | Active not recruiting | W.L.Gore & Associates | 10 | 2024-08-19 | 2026-07-16 |
| Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness CorNeat KPro - Corneal Disease, Corneal Opacity | Not applicable | Terminated | CorNeat Vision Ltd. | 15 | 2024-06-27 | 2026-05-07 |
| Photorefractive Keratectomy (PRK) : Comparison of Corneal Haze Between Two Modes of De-epithelialisation (Laser Versus Manual Alcohol) TransPRK, Alcohol PRK - Myopia, Astigmatism | Not applicable | Terminated | Fondation Ophtalmologique Adolphe de Rothschild | 71 | 2022-02-09 | 2025-12-08 |
| First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness CorNeat KPro - Corneal Disease, Corneal Opacity | Not applicable | Terminated | CorNeat Vision Ltd. | 10 | 2021-01-03 | 2024-09-24 |
| Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery bandage contact lenses(PureVision; Bausch & Lomb Inc., Rochester, NY), phacoemulsification - Cataract, Lens Subluxation | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 30 | 2020-03-13 | 2021-04-05 |
| Implantable Intraocular Pressure Sensor for Glaucoma Monitoring in Patients With Boston Keratoprosthesis Type 1 EyeMate - Glaucoma, Blindness, Acquired | Not applicable | Withdrawn | Centre hospitalier de l'Université de Montréal (CHUM) | 2016-11-01 | 2018-02-05 | |
| Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP closed PKP under topical anesthesia, open-sky PKP under retrobulbar anesthesia, Anti-Rejection Agents - Corneal Opacity, Keratitis, Herpetic | Not applicable | Unknown | Wenzhou Medical University | 60 | 2015-12-01 | 2016-07-07 |
| Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar Keratoplasty RHCIII-MPC cornea, Donor cornea - Leukoma | Not applicable | Completed | L.V. Prasad Eye Institute | 2 | 2015-05-01 | 2018-08-09 |
| OCT-guided LALAK for KCN LALAK, IEK, Retrobulbar Block or General Anesthesia - Corneal Opacity, Keratoconus | Not applicable | Terminated | Oregon Health and Science University | 5 | 2013-08-01 | 2019-01-23 |
| Safety and Effectiveness of Collagen-phosphorylcholine Bioengineered Cornea in Patients Requiring Lamellar Keratoplasty Collagen-MPC cornea - Corneal Ulcer, Leukoma | Not applicable | Completed | The Filatov Institute of Eye Diseases and Tissue Therapy | 5 | 2013-03-01 | 2018-10-26 |
| Femtosecond Laser-assisted Anterior Lamellar Keratoplasty FS-ALK (Femtolaser-assisted anterior lamellar keratoplasty) - Keratoconus, Corneal Opacity | Not applicable | Completed | The S.N. Fyodorov Eye Microsurgery State Institution | 13 | 2012-01-01 | 2014-12-02 |
| OCT-guided LALAK in Children OCT guided laser-assisted lamellar anterior keratoplasty (LALAK), Penetrating Keratoplasty (KP) - Corneal Opacity | Not applicable | Terminated | Oregon Health and Science University | 1 | 2012-01-01 | 2018-04-17 |
| Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy OCT-guided laser phototherapeutic keratectomy - Corneal Opacity | Not applicable | Recruiting | Oregon Health and Science University | 80 | 2011-06-01 | 2024-02-12 |
| Laser Assisted Procedures in Penetrating Keratoplasty Penetrating keratoplasty, Femtosecond laser, Diode laser - Keratoconus, Corneal Dystrophies | Not applicable | Completed | Ospedale Santo Stefano | 22 | 2011-01-01 | 2014-06-25 |
| Phototherapeutic Keratectomy (PTK) With Mitomycin in Adenoviral Opacities PTK with mitomycin in Adenoviral Opacities - Keratitis, Corneal Opacity | Not applicable | Unknown | Federal University of São Paulo | 30 | 2006-04-01 | 2008-08-04 |
Corneal Diseases (4) · Corneal Injuries (4) · Keratoconus (4) · Corneal Dystrophies, Hereditary (3) · Corneal Ulcer (2) · Keratitis, Herpetic (2) · Astigmatism (1) · Blindness (1) · Cataract (1) · Dry Eye Syndromes (1) · Glaucoma (1) · Keratitis (1) · Lens Subluxation (1) · Miosis (1)
Eye Diseases (17) · Corneal Diseases (13) · Nervous System Diseases (5) · Craniocerebral Trauma (4) · Eye Injuries (4) · Facial Injuries (4) · Trauma, Nervous System (4) · Wounds and Injuries (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Eye Diseases, Hereditary (3) · Eye Infections (3) · Genetic Diseases, Inborn (3) · Infections (3) · Keratitis (3) · DNA Virus Infections (2)
Keratoplasty, Penetrating (2) · Anesthesia (1) · Anesthesia, General (1) · Anti-Inflammatory Agents (1) · Ethanol (1) · Lasers, Semiconductor (1) · Losartan (1) · Mitomycin (1) · Phacoemulsification (1) · Tomography, Optical Coherence (1)
Oregon Health and Science University (3) · CorNeat Vision Ltd. (2) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Federal University of São Paulo (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Instituto de Oftalmología Fundación Conde de Valenciana (1) · L.V. Prasad Eye Institute (1) · Ospedale Santo Stefano (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · The Filatov Institute of Eye Diseases and Tissue Therapy (1) · The S.N. Fyodorov Eye Microsurgery State Institution (1) · Universidad Autonoma de Nuevo Leon (1) · W.L.Gore & Associates (1) · Wenzhou Medical University (1)
United States (4) · France (3) · Mexico (3) · Canada (2) · China (2) · Israel (2) · Netherlands (2) · Brazil (1) · India (1) · Italy (1) · Ukraine (1)
Arturo Ramirez Miranda, MD (1) · Bibiana Reiser, MD (1) · Boris Malyugin, MD,PhD,prof. (1) · David Huang, MD, PhD (1) · Ester S Yamazaki, MD (1) · Karim Mohamed-Noriega, Dr. med. (1) · Luca Menabuoni, MD (1) · Mauro S Campos, MD (1) · Mona Harissi-Dagher, MD (1) · Nataliya Pasyechnikova, MD, PhD, DSc (1) · Valeria Sanchez Huerta, MD (1) · Virender S Sangwan, MBBS, MS (1) · Winston Chamberlain, MD, PhD (1)
PMID 19097643, PMID 20847116, PMID 21109229, PMID 24374070, PMID 38549070, PMID 40810416
R01EY018184 (2)