57 unknown. 57 Phase 3, 21 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 57 | Unknown 57 |
| Phase 2 | 21 | Unknown 21 |
Follow Congenital Abnormalities: new trials by email Literature Review of Congenital Abnormalities trials Research Report on Congenital Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIH Giomer varnish, Fluoride varnish - Molar Incisor Hypomineralization | Phase 3 | Unknown | Cairo University | 24 | 2025-02-01 | 2023-09-01 |
| Liposomal Bupivacaine Use in Alveolar Bone Graft Patients Liposomal Bupivacaine, Bupivacain, Epinephrine - Cleft Lip and Palate | Phase 3 | Unknown | Kerry O'Rourke | 60 | 2024-04-24 | 2024-07-03 |
| CVL237 Tablets for APDS/PASLI CVL237 tablets, CVL237 placebo tablets - PI3K and P110delta Hyperactivation Syndrome | Phase 2 / Phase 3 | Unknown | Convalife (Shanghai) Co., Ltd. | 35 | 2024-03-30 | 2024-03-05 |
| A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Glycerin 0.2%/Hypromellose 0.2%/Peg 1%/Soln,Oph,Ud - Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy | Phase 2 / Phase 3 | Unknown | Wills Eye | 80 | 2023-02-06 | 2024-07-30 |
| " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " Sacubitril 49 MG / Valsartan 51 MG [Entresto] BID, Empagliflozin 10 MG OD - Congenital Heart Disease, Heart Failure | Phase 2 / Phase 3 | Unknown | Instituto Nacional de Cardiologia Ignacio Chavez | 160 | 2023-02-06 | 2022-11-02 |
| Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin - Retrognathism, Prognathism | Phase 2 / Phase 3 | Unknown | Universitat Internacional de Catalunya | 220 | 2022-09-30 | 2022-09-13 |
| Long-term Interventional Follow-up Study of Children With Prader-Willi Syndrome Included in the OTBB3 Clinical Trial Follow-up study of the treated cohort, Follow-up study of the untreated cohort - Prader-Willi Syndrome | Phase 3 | Unknown | University Hospital, Toulouse | 80 | 2021-09-07 | 2024-04-30 |
| PAIR (Paracetamol and Ibuprofen Research) Pilot Trial Paracetamol injection, Ibuprofen injection - Patent Ductus Arteriosus | Phase 2 / Phase 3 | Unknown | Manchester University NHS Foundation Trust | 32 | 2021-09-03 | 2023-10-30 |
| Feasibility of Use of Indocyanine Green in Pediatric Colorectal Surgery Indocyanine green - Hirschsprung Disease, Anorectal Malformations | Phase 3 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 12 | 2021-06-16 | 2024-03-15 |
| Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study Testosterone gel, Placebo - Disorder of Sex Development, 46,XY | Phase 3 | Unknown | Erasmus Medical Center | 1 | 2021-06-01 | 2021-04-05 |
| Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (RS)-baclofen, naltrexone hydrochloride and D-sorbitol, Placebo - Charcot-Marie-Tooth Disease | Phase 3 | Unknown | Pharnext S.C.A. | 350 | 2021-03-30 | 2024-04-03 |
| An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. sepofarsen - Leber Congenital Amaurosis 10, Blindness | Phase 2 / Phase 3 | Unknown | ProQR Therapeutics | 15 | 2021-03-23 | 2022-03-25 |
| Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT passive range of motion exercise therapy - Congenital Heart Disease | Phase 3 | Unknown | Carelon Research | 144 | 2021-02-23 | 2024-07-03 |
| Assessment of Postop Hypospadias Pain Acetaminophen, Ibuprofen, Acetaminophen, Ibuprofen, Oxycodone - Hypospadias | Phase 3 | Unknown | University of Oklahoma | 150 | 2020-07-01 | 2020-07-31 |
| Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study Rivaroxaban, Warfarin, Nadroparin - May-Thurner Syndrome | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 224 | 2020-05-18 | 2024-04-18 |
| Metformin vs Tolvaptan for Treatment of Autosomal Dominant Polycystic Kidney Disease Metformin, Tolvaptan - ADPKD | Phase 3 | Unknown | Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari | 150 | 2019-01-30 | 2018-12-07 |
| Alternative Paracetamol Treatments for the Neonate With a hsPDA Rectal Solution, Intravenous Infusion - Ductus Arteriosus, Patent | Phase 2 / Phase 3 | Unknown | Shaare Zedek Medical Center | 80 | 2018-09-01 | 2018-07-30 |
| A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone Injection in Patients With Prader-Willi Syndrome Recombinant Human Growth Hormone (rhGH) Injection - Prader-Willi Syndrome | Phase 3 | Unknown | Changchun GeneScience Pharmaceutical Co., Ltd. | 30 | 2018-04-14 | 2018-06-12 |
| Efficacy and Safety of Rapamycin to Complex Vascular Anomalies in Pediatric Patients Treatment with oral rapmycin - Vascular Anomalies | Phase 2 / Phase 3 | Unknown | Zhujiang Hospital | 30 | 2017-12-01 | 2021-11-10 |
| Treatment of Congenital Vascular Malformations Using Sirolimus: Improving Quality of Life Sirolimus - Vascular Malformations | Phase 3 | Unknown | Radboud University Medical Center | 75 | 2017-09-18 | 2021-01-29 |
Showing 20 of 57. Sign in to see all of them.
Heart Defects, Congenital (7) · Hereditary Sensory and Autonomic Neuropathies (5) · Leukemia, Myeloid, Acute (4) · Polycystic Kidney Diseases (4) · Polycystic Kidney, Autosomal Dominant (4) · Charcot-Marie-Tooth Disease (3) · Ductus Arteriosus, Patent (3) · Heart Failure (3) · Leukemia (3) · Leukemia, Erythroblastic, Acute (3) · Leukemia, Megakaryoblastic, Acute (3) · Leukemia, Monocytic, Acute (3) · Leukemia, Myelomonocytic, Acute (3) · Foramen Ovale, Patent (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (57) · Genetic Diseases, Inborn (24) · Cardiovascular Diseases (23) · Cardiovascular Abnormalities (21) · Nervous System Diseases (18) · Heart Diseases (16) · Abnormalities, Multiple (12) · Pathological Conditions, Signs and Symptoms (11) · Female Urogenital Diseases (10) · Female Urogenital Diseases and Pregnancy Complications (10) · Male Urogenital Diseases (10) · Nervous System Malformations (10) · Neurodegenerative Diseases (10) · Urogenital Diseases (10)
Acetaminophen (3) · Ibuprofen (3) · Sirolimus (3) · Infusions, Intravenous (2) · Losartan (2) · lanreotide (2) · Atenolol (1) · BID protein, human (1) · Biological Dressings (1) · Botulinum Toxins, Type A (1) · Bupivacaine (1) · Busulfan (1) · Cyclophosphamide (1) · Cytarabine (1) · Cytidine (1)
Assistance Publique - Hôpitaux de Paris (2) · Erasmus Medical Center (2) · Ethicare GmbH (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · NMT Medical (2) · Pharnext S.C.A. (2) · Radboud University Medical Center (2) · Azienda Ospedaliera Universitaria Integrata Verona (1) · Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari (1) · Bambino Gesù Hospital and Research Institute (1) · Baylor Research Institute (1) · Beijing Tiantan Hospital (1) · Cairo University (1) · Carelon Research (1) · Centre Hospitalier Universitaire de Nice (1)
United States (12) · Netherlands (10) · China (8) · United Kingdom (8) · Canada (7) · France (7) · Italy (7) · Belgium (5) · Spain (4) · Austria (3) · Germany (2) · Hungary (2) · Iran (2) · Israel (2) · Serbia (2)
Christoph Male, Prof,MD,PhD (2) · Ida Jovanovic, Prof,MD,PhD (2) · Mark Reisman, MD (2) · Michael Burch, Prof,MD,PhD (2) · Michiel Dalinghaus, MD,PhD (2) · Alberto Forteza, Dr (1) · Andreana Butter, MD (1) · Angelo E Schenone, MD (1) · Anthony Furlan, MD (1) · Arin Mukherjee, MRCPCH (1) · Arthur J Dalton, PhD (1) · Arturo Evangelista, Dr (1) · Babak Babsharif, MD (1) · Barry J.A. Laird, MD (1)
PMID 39356039, PMID 16601194, PMID 17188619, PMID 17911499, PMID 19430350, PMID 21051670, PMID 22417252, PMID 23796341, PMID 24297940, PMID 24824357, PMID 24884885, PMID 24986689, PMID 25147037, PMID 25341453, PMID 25899445, PMID 26811524, PMID 27367242, PMID 27995519, PMID 29547081, PMID 29926156, PMID 30422235, PMID 30520545, PMID 30523055, PMID 31022403, PMID 31033140, PMID 31217257, PMID 31379715, PMID 32865377, PMID 32993773, PMID 33186500, PMID 33447845, PMID 33779943, PMID 33832352, PMID 37153086, PMID 38837240, PMID 41550606, PMID 42568743, PMID 42745265
2015 (3), 2016 (2), 2008 (1), R01AG016381 (1)