110 completed, 39 recruiting, 21 unknown, 19 active not recruiting. 50 Phase 2, 42 Phase 3, 41 Not applicable, 25 Phase 1, 8 Phase 4.
Follow Polycystic Kidney Diseases: new trials by email Literature Review of Polycystic Kidney Diseases trials Research Report on Polycystic Kidney Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Pharmacokinetics of JMKX003142 in Healthy Participants and Participants With Hepatic Impairment JMKX003142 - ADPKD (Autosomal Dominant Polycystic Kidney Disease), Renal Edema | Phase 1 | Not yet recruiting | Jemincare | 32 | 2026-11-20 | 2026-11-02 |
| GBP-213 in Patients With Autosomal Dominant Polycystic Kidney Disease GBP-213 - Autosomal Dominant Polycystic Kidney | Early Phase 1 | Not yet recruiting | RenJi Hospital | 24 | 2026-11-01 | 2026-10-23 |
| Absorption, Distribution, Metabolism, and Excretion of 14C-VX-407 After a Single Oral Dose 14C-VX-407 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Phase 1 | Recruiting | Vertex Pharmaceuticals Incorporated | 8 | 2026-10-16 | 2026-10-30 |
| Effects of VX-407 on the Pharmacokinetics of Combined Oral Contraceptives VX-407, LNG/EE, NGM/EE - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Phase 1 | Recruiting | Vertex Pharmaceuticals Incorporated | 148 | 2026-09-01 | 2026-09-30 |
| Bempedoic Acid Therapy for Polycystic Kidney Disease Bempedoic Acid 180 MG Oral Tablet, Placebo Capsule(s) - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 2 | Recruiting | Kenneth Hallows | 120 | 2026-09-01 | 2026-09-29 |
| Dietary Modulation of Urinary MCP-1 in ADPKD Carbohydrate Restricted, Plant Dominant Diet, usual diet - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Not applicable | Not yet recruiting | Assaf-Harofeh Medical Center | 36 | 2026-07-10 | 2026-06-26 |
| A Phase 1 Study of Single and Multiple Ascending Doses of GV-100 GV-100, Placebo - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 1 | Recruiting | Gilva Therapeutics Inc. | 80 | 2026-06-23 | 2026-08-26 |
| Managing Depressive Symptoms in ADPKD Mayo Clinic-Approved Education, Digital Neuropathy, Capacity Coaching - Autosomal Dominant Polycystic Kidney Disease | Not applicable | Recruiting | Mayo Clinic | 105 | 2026-06-12 | 2026-08-07 |
| Drug-Drug Interactions of JMKX003142 in Healthy Participants JMKX003142 tablets, Fluconazole Capsules, Cocktail Substrates (Midazolam Oral Solution, Rosuvastatin Calcium Tablets, and Digoxin Tablets) - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 1 | Not yet recruiting | Jemincare | 112 | 2026-05-11 | 2026-05-04 |
| Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease Interventional Diet - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Not applicable | Not yet recruiting | Loma Linda University | 30 | 2026-05-01 | 2026-01-30 |
| A Study to Investigate the Effects of JMKX003142 on QTc Interval in Healthy Adults JMKX003142 tablets, Placebo - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 1 | Not yet recruiting | Jemincare | 24 | 2026-03-27 | 2026-03-13 |
| Mass Balance and Absolute Bioavailability Study of JMKX003142 In Healthy Volunteers [14C]JMKX003142, JMKX003142 tablets, [14C]JMKX003142 solution for infusion - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 1 | Not yet recruiting | Jemincare | 8 | 2026-03-18 | 2026-03-10 |
| Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease Ren-Nu and KetoCitra - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Not applicable | Recruiting | Richard Fatica | 20 | 2026-02-25 | 2026-03-06 |
| STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney Disease Dapagliflozin 10 mg, Matching Placebo - Polycystic Kidney, Autosomal Dominant | Phase 3 | Recruiting | University of Cologne | 420 | 2025-12-16 | 2026-07-28 |
| Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW) VX-407 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Phase 2 | Active not recruiting | Vertex Pharmaceuticals Incorporated | 26 | 2025-11-19 | 2026-09-21 |
| Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease AZD1613 - Part A, Placebo - Part A, AZD1613 - Part B - Autosomal Dominant Polycystic Kidney Disease | Phase 1 | Recruiting | AstraZeneca | 40 | 2025-11-10 | 2026-10-13 |
| Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects Amiodarone Hydrochloride Tablets, Febuxostat Tablets - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Phase 1 | Not yet recruiting | Jemincare | 48 | 2025-10-30 | 2025-09-18 |
| Somatosensory Phenotyping of ADPKD Quantitative Sensory Testing, Questionnaires regarding pain and quality of life - ADPKD, Pain | Recruiting | Universitaire Ziekenhuizen KU Leuven | 150 | 2025-09-09 | 2025-11-17 | |
| Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease Autosomal Dominant Polycystic Kidney Disease (ADPKD | Recruiting | King's College London | 200 | 2025-08-15 | 2026-11-04 | |
| Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants VX-407, LNG/EE, NGM/EE - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 74 | 2025-07-11 | 2026-03-30 |
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Polycystic Kidney, Autosomal Dominant (184) · Kidney Diseases (14) · Renal Insufficiency, Chronic (14) · Polycystic liver disease (13) · Hypertension (11) · Polycystic Kidney, Autosomal Recessive (8) · Diabetes Insipidus (4) · Cysts (3) · Glomerulonephritis, IGA (3) · Hepatomegaly (3) · Ketosis (3) · Kidney Diseases, Cystic (3) · Liver Diseases (3) · Nephronophthisis, familial juvenile (3)
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Tolvaptan (21) · Sirolimus (9) · lixivaptan (5) · Blood Specimen Collection (4) · XL647 (4) · lanreotide (4) · Diet (3) · Diet, Ketogenic (3) · Everolimus (3) · Metformin (3) · Pravastatin (3) · Sodium Chloride (3) · bardoxolone methyl (3) · empagliflozin (3) · Angiotensin-Converting Enzyme Inhibitors (2)
Mayo Clinic (15) · Otsuka Pharmaceutical Development & Commercialization, Inc. (12) · University of Colorado, Denver (12) · Mario Negri Institute for Pharmacological Research (11) · Jemincare (7) · Vertex Pharmaceuticals Incorporated (7) · Palladio Biosciences (5) · The Rogosin Institute (5) · Kyorin University (4) · Radboud University Medical Center (4) · Regional Hospital Holstebro (4) · University of Cologne (4) · Assistance Publique - Hôpitaux de Paris (3) · Biogen (3) · Otsuka Pharmaceutical Co., Ltd. (3)
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Jon Blumenfeld, MD (4) · Marva Moxey-Mims, M.D. (3) · Vicente Torres, MD, PhD (3) · Arlene Chapman, M.D. (2) · Arlene Chapman, MD (2) · Changlin Mei, MD (2) · Eiji Higashihara, M.D. (2) · Eiji Higashihara, MD (2) · Frank Czerwiec, M.D., Ph.D. (2) · Frank Czerwiec, MD, PhD (2) · Frederik Nevens, MD, PhD (2) · Gere Sunder-Plassmann, MD (2) · Giuseppe Remuzzi, M.D. (2)
PMID 39356039, PMID 41385299, PMID 37250503, PMID 41348481, PMID 36191725, PMID 37349694, PMID 38837240, PMID 31014270, PMID 21903984, PMID 37729939, PMID 37986188, PMID 40377984, PMID 16221708, PMID 17868472, PMID 18372389, PMID 19141364, PMID 19525519, PMID 19540516, PMID 20581391, PMID 20581392, PMID 20876670, PMID 21694639, PMID 21757630, PMID 22113127, PMID 22205355, PMID 22417271, PMID 22773240, PMID 23071528, PMID 23520042, PMID 23732715, PMID 23887359, PMID 23972263, PMID 24374109, PMID 24470398, PMID 24489795, PMID 25111236, PMID 25214022, PMID 25399731, PMID 25399733, PMID 25663351, PMID 25899445, PMID 26166166, PMID 26386044, PMID 26718059, PMID 26811129, PMID 26844873, PMID 26912555, PMID 27095636, PMID 27212247, PMID 27222591
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