8 completed. 8 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 8 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
Follow Combat Disorders: new trials by email Literature Review of Combat Disorders trials Research Report on Combat Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder) Esketamine (Intranasal Spray), Massed Prolonged Exposure (PE) - Post Traumatic Stress Disorder PTSD | Phase 1 / Phase 2 | Completed | The University of Texas Health Science Center at San Antonio | 4 | 2025-06-09 | 2026-01-28 |
| MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD 3,4-methylenedioxymethamphetamine - Post Traumatic Stress Disorder, Combat Stress Disorders | Phase 2 | Completed | VA Loma Linda Health Care System | 5 | 2021-07-29 | 2025-07-20 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
| Trauma Management Therapy for OEF and OIF Combat Veterans 17 week Exposure Therapy Control Arm, Trauma Management Therapy, Intensive 3-Week Trauma Management Therapy - Post-Traumatic Stress Disorder, Combat Disorders | Phase 2 | Completed | University of Central Florida | 180 | 2015-11-01 | 2017-10-31 |
| Military to Civilian: Trial of an Intervention to Promote Postdeployment Reintegration Expressive Writing, Control Writing - Posttraumatic Stress Disorder | Phase 2 / Phase 3 | Completed | Minneapolis Veterans Affairs Medical Center | 1292 | 2011-06-01 | 2015-09-23 |
| Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD - Combat Disorders, Posttraumatic Stress Disorder | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 36 | 2008-01-01 | 2019-02-15 |
| Propranolol in Post Traumatic Stress Disorder propranolol - Post-Traumatic Stress Disorder | Phase 2 | Completed | University Hospital, Toulouse | 20 | 2007-04-01 | 2009-01-07 |
| Cognitive Therapy for PTSD in Addiction Treatment Cognitive Behavioral Therapy (CBT) - Stress Disorders, Post Traumatic, Substance-Related Disorders | Phase 1 / Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 49 | 2004-11-01 | 2011-09-29 |
Stress Disorders, Post-Traumatic (6) · Behavior, Addictive (1) · Brain Concussion (1) · Headache (1) · Post-Concussion Syndrome (1) · Post-Traumatic Headache (1) · Substance-Related Disorders (1) · Wounds and Injuries (1)
Mental Disorders (8) · Stress Disorders, Traumatic (8) · Trauma and Stressor Related Disorders (8) · Behavior (1) · Brain Diseases (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Central Nervous System Diseases (1) · Chemically-Induced Disorders (1) · Compulsive Behavior (1) · Craniocerebral Trauma (1) · Head Injuries, Closed (1) · Headache Disorders (1) · Headache Disorders, Secondary (1) · Impulsive Behavior (1)
Cognitive Behavioral Therapy (1) · Esketamine (1) · Implosive Therapy (1) · N-Methyl-3,4-methylenedioxyamphetamine (1) · Prazosin (1) · Propranolol (1)
VA Office of Research and Development (2) · Dartmouth-Hitchcock Medical Center (1) · Minneapolis Veterans Affairs Medical Center (1) · The University of Texas Health Science Center at San Antonio (1) · University Hospital, Toulouse (1) · University of Central Florida (1) · VA Loma Linda Health Care System (1)
United States (7) · France (1)
Casey Straud, PsyD (1) · Cynthia L Mayer, DO (1) · Deborah C Beidel, Ph.D., ABPP (1) · Mark P. McGovern, Ph.D. (1) · Nina A Sayer, PhD (1) · Shannon Remick, MD (1) · Sheila Rauch, PhD (1)
PMID 23696427, PMID 24913102, PMID 28102979, PMID 35950709
1IK2RX001136-01A2 (1), K23DA016574 (1)