4 completed, 2 recruiting, 1 enrolling by invitation. 7 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Recruiting 2, Enrolling by invitation 1 |
| Phase 1 | 3 | Completed 2, Recruiting 1 |
Follow Cleft Lip: new trials by email Literature Review of Cleft Lip trials Research Report on Cleft Lip
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Evaluation of a Novel Nasal Conformer in Pediatric Patients use of an anatomically designed nasal conformer - Cleft Lip, Nasal Surgical Procedures | Phase 2 | Enrolling by invitation | East Tennessee Children's Hospital | 20 | 2025-06-01 | 2026-09-16 |
| Phase I-IIa, to Evaluate the Safety, Feasibility, and Efficacy of the Use of BIOCLEFT in the Treatment of Cleft Palate. implantation with an autologous human palatal mucosa substitute made of nanostructured fibrin-agarose generated by tissue engineering (BIOCLEFT). - Cleft Lip and Palate | Phase 1 / Phase 2 | Recruiting | Elisa María Cubiles Montero de Espinosa | 15 | 2024-04-17 | 2024-05-10 |
| Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Botulinum Toxin Type A, Normal Saline Injection - Cleft Lip, Scarring | Phase 1 / Phase 2 | Completed | The University of Texas Health Science Center, Houston | 30 | 2015-12-01 | 2021-11-03 |
| Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone) Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold) - Clift Lip, Cleft Palate | Phase 1 / Phase 2 | Completed | Hospital Sirio-Libanes | 20 | 2015-03-01 | 2026-07-29 |
| Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Orthognathic surgery, Distraction osteogenesis - Cleft Lip and Palate, Maxillary Hypoplasia | Phase 2 | Completed | The University of Hong Kong | 60 | 2002-06-01 | 2011-09-13 |
| Cleft Palate Surgery and Speech Development Furlow double z-plasty palatoplasty palate repair, Von Langenbeck palatoplasty palate repair - Cleft Lip, Cleft Palate | Phase 2 | Completed | University of Florida | 475 | 1996-02-01 | 2011-09-20 |
Cleft Palate (3) · Alveolar Bone Loss (1) · Cicatrix (1) · Pain, Postoperative (1) · Retrognathia (1) · Speech (1)
Congenital Abnormalities (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Lip Diseases (7) · Mouth Abnormalities (7) · Mouth Diseases (7) · Stomatognathic Diseases (7) · Stomatognathic System Abnormalities (7) · Craniofacial Abnormalities (4) · Jaw Abnormalities (4) · Jaw Diseases (4) · Maxillofacial Abnormalities (4) · Musculoskeletal Abnormalities (4) · Musculoskeletal Diseases (4) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2)
Botulinum Toxins, Type A (2) · Saline Solution (2) · Drug Implants (1) · Orthognathic Surgery (1) · Osteogenesis, Distraction (1) · Sodium Chloride (1)
Children's National Research Institute (1) · East Tennessee Children's Hospital (1) · Elisa María Cubiles Montero de Espinosa (1) · Hospital Sirio-Libanes (1) · The University of Hong Kong (1) · The University of Texas Health Science Center, Houston (1) · University of Florida (1)
United States (4) · Brazil (2) · Hong Kong (1) · Spain (1)
Jaecel O Shah, MD (1) · Lim K Cheung, BDS, PhD (1) · William N Williams, Ph.D (1)
R01DE010437 (1)