10 recruiting, 8 not yet recruiting, 4 completed, 2 enrolling by invitation. 14 Not applicable, 3 Phase 3, 2 Phase 1, 2 Phase 2.
Follow Chronic Rhinosinusitis (CRS): new trials by email Literature Review of Chronic Rhinosinusitis (CRS) trials Research Report on Chronic Rhinosinusitis (CRS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction Nasal Drops, Nasal Spray - Chronic Rhinosinusitis (CRS), Olfactory Dysfunction | Not applicable | Not yet recruiting | Peking University Third Hospital | 78 | 2026-09-25 | 2026-09-16 |
| Pistacia Lentiscus Oil Nasal Spray With Reduced-Dose Mometasone in Chronic Rhinosinusitis Mometasone furoate - intranasal application, Bactorinol nasal spray - Chronic Rhinosinusitis (CRS) | Not applicable | Not yet recruiting | Liaquat University of Medical & Health Sciences | 64 | 2026-09-07 | 2026-08-26 |
| Active vs. Passive VR During Office-based ENT Procedures Passive virtual reality headset or goggles, Active virtual reality headset or goggles - Pain, Anxiety | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 132 | 2026-09-01 | 2026-08-17 |
| Triamcinolone Nanocapsules After Endoscopic Nasal Surgery Triamcinolone Acetonide-Loaded Polymeric Nanocapsules, Normal Saline Nasal Irrigation - Chronic Rhinosinusitis (CRS), Nasal Polyps | Phase 2 | Recruiting | Deraya University | 50 | 2026-05-01 | 2026-07-27 |
| Propel Drug-Eluting Sinus Implant Family IBUKI Cohort None, observational standard of care study - Chronic Rhinosinusitis (CRS) | Recruiting | Medtronic | 100 | 2026-04-01 | 2026-04-23 | |
| Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis Povidone-Iodine and Budesonide Gel-Forming Suspension, Placebo Gel-Forming Suspension - Chronic Rhinosinusitis (CRS) | Phase 3 | Not yet recruiting | Amin Javer | 180 | 2026-03-30 | 2026-02-03 |
| Evaluation of the Safety and Performance of a Bioresorbable Nasal Dressing Containing Mometasone Furoate (MF) OCEAN, Steroid-eluting sinus stent - Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps | Not applicable | Enrolling by invitation | Polyganics BV | 110 | 2026-03-19 | 2026-06-25 |
| Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training Smell Training - Smell Loss, Chronic Rhinosinusitis (CRS) | Not applicable | Recruiting | The Cleveland Clinic | 52 | 2025-12-09 | 2026-07-02 |
| Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures Lavender Aromatherapy, Placebo Aromatherapy - Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS) | Not applicable | Recruiting | Cedars-Sinai Medical Center | 184 | 2025-12-01 | 2025-12-23 |
| A Phase I Study Evaluating the Safety, Tolerability, and Pharmacokinetics of VVN432 Nasal Spray 0.5% VVN432 Nasal Spray, 1% VVN432 Nasal Spray, Vehicle - Chronic Rhinosinusitis (CRS) | Phase 1 | Recruiting | VivaVision Biotech, Inc | 60 | 2025-11-06 | 2025-12-02 |
| The German National CRS Registry (GenreCRS): Clinical Evaluation of the New European Academy for Allergy and Clinical Immunology (EAACI) Criteria for CRSwNP Disease Control, Remission and Cure in a Real-World Evidence Study Approach Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps | Not yet recruiting | Ärzteverband Deutscher Allergologen e.V. | 500 | 2025-10-01 | 2025-06-04 | |
| Long-term Effect of Dupilumab in N-ERD Observational follow-up of standard Dupilumab treatment - NSAID-Induced Asthma, NSAIDs Hypersensitivity | Completed | Medical University of Vienna | 15 | 2025-09-01 | 2026-10-07 | |
| Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults - URTI, Bronchiolitis | Not applicable | Recruiting | Laboratoire de la Mer | 1065 | 2025-08-27 | 2025-12-03 |
| Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID, CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID - Cystic Fibrosis (CF), Chronic Rhinosinusitis (CRS) | Phase 3 | Recruiting | Indiana University | 64 | 2025-07-02 | 2025-12-16 |
| Treatment Decision-Making Among Patients With Chronic Rhinosinusitis Patient Centered CRS Treatment Decision Support - Chronic Rhinosinusitis (CRS) | Not applicable | Enrolling by invitation | University of Southern California | 50 | 2025-06-02 | 2025-12-18 |
| Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS Computed Tomography - Chronic Rhinosinusitis (CRS) | Not yet recruiting | Peking University Third Hospital | 80 | 2025-03-14 | 2025-02-19 | |
| Product Surveillance Registry; Ear, Nose and Throat - EXTEND Cohort Observational data collection from patients with chronic rhinosinusitis (CRS) receiving PROPEL sinus implant(s) following functional endoscopic sinus surgery (FESS) - Chronic Rhinosinusitis (CRS) | Withdrawn | Medtronic | 2025-01-30 | 2025-05-15 | ||
| Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery Bilateral Trans-nasal Sphenopalatine Ganglion Block, Sham Trans-nasal Injection - Chronic Rhinosinusitis (CRS), Emergence Agitation | Not applicable | Completed | Mansoura University | 100 | 2025-01-05 | 2026-06-12 |
| Endoscopic Direct "Draf IIa" (Carolyn's Window Approach) Versus Endoscopic Angled "Draf IIa"Approach in Chronic Rhinosinusitis With Frontal Sinus Affection ( A Comparative Study ). Endoscopic direct Draf IIa, Endoscopic angled Draf IIa - Chronic Rhinosinusitis (CRS), Frontal Sinusitis | Not applicable | Not yet recruiting | Assiut University | 68 | 2025-01-01 | 2024-10-31 |
| Impact of Climate Change Anxiety on Sinusitis Symptoms and Quality of Life Among Adults With Chronic Rhinosinusitis: A Cross-Sectional Study Chronic Rhinosinusitis (CRS), Climate Change Anxiety | Completed | Sinai University | 134 | 2025-01-01 | 2026-08-04 |
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Nasal Polyps (6) · Allergic Fungal Sinusitis (1) · Anosmia (1) · Anxiety Disorders (1) · Asthma (1) · Asthma, Aspirin-Induced (1) · Bronchiolitis (1) · COVID-19 (1) · Cystic Fibrosis (1) · Dysphonia (1) · Emergence Delirium (1) · Frontal Sinusitis (1) · Nasal Obstruction (1) · Pain (1) · Pain, Postoperative (1)
Respiratory Tract Diseases (11) · Nose Diseases (9) · Otorhinolaryngologic Diseases (9) · Pathological Conditions, Signs and Symptoms (7) · Pathological Conditions, Anatomical (6) · Polyps (6) · Infections (4) · Bronchial Diseases (3) · Hypersensitivity (3) · Hypersensitivity, Immediate (3) · Immune System Diseases (3) · Lung Diseases (3) · Nervous System Diseases (3) · Neurologic Manifestations (3) · Respiratory Hypersensitivity (3)
dupilumab (2) · Control Groups (1) · Eye Protective Devices (1) · Olfactory Training (1) · Omalizumab (1) · Povidone-Iodine (1) · Steroids (1) · Tobacco Use Cessation Devices (1) · Ultrasonic Therapy (1) · mepolizumab (1)
Cedars-Sinai Medical Center (2) · Medtronic (2) · Peking University Third Hospital (2) · Amin Javer (1) · Assiut University (1) · Cairo University (1) · Deraya University (1) · Foundation University Islamabad (1) · Indiana University (1) · Laboratoire de la Mer (1) · Liaquat University of Medical & Health Sciences (1) · Mansoura University (1) · Medical University of Vienna (1) · National Institute on Deafness and Other Communication Disorders (NIDCD) (1) · Pleuran, s.r.o. (1)
United States (6) · Egypt (4) · China (3) · Austria (1) · Belgium (1) · Canada (1) · Czechia (1) · France (1) · Italy (1) · Japan (1) · Pakistan (1) · Slovakia (1)
Amir Mostafa Shabana, MD (1) · Ankona Ghosh, MD (1) · Elisa Illing, MD (1) · Joshua Levy, M.D. (1) · Mohamad Chaaban, MD (1) · Peter Hellings, MD,PhD (1) · Sally Mansour Helmy (1) · Shinyi Wu, PhD (1)