14 terminated. 14 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Terminated 14 |
Follow Chronic Obstructive Pulmonary Disease: new trials by email Literature Review of Chronic Obstructive Pulmonary Disease trials Research Report on Chronic Obstructive Pulmonary Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER) Experimental: CHF6001 1600µg, Experimental: CHF6001 3200µg, Placebo - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Chiesi Farmaceutici S.p.A. | 4710 | 2021-07-14 | 2025-12-17 |
| A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) CHF6001 1600µg, CHF6001 3200µg, Placebo - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Chiesi Farmaceutici S.p.A. | 3973 | 2021-07-12 | 2026-02-02 |
| Inhaled Treprostinil in Participants With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD) Inhaled treprostinil solution - Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | United Therapeutics | 41 | 2018-12-21 | 2026-05-27 |
| A Randomized Study to Evaluate the Effect of Reminder Notifications and Motivational/Adaptive Messaging on Treatment Adherence Concept2 inhaler, Concept2 inhaler with patient application - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Novartis Pharmaceuticals | 7 | 2018-07-11 | 2021-01-05 |
| A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) Inhaled treprostinil solution, Placebo solution - Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | United Therapeutics | 188 | 2018-05-08 | 2023-11-24 |
| Smoking Relapse Prevention Among COPD Ex-smokers Varenicline, Behavioural support, Placebo - Chronic Obstructive Pulmonary Disease, Smoking Cessation | Phase 3 | Terminated | University of Auckland, New Zealand | 8 | 2017-07-31 | 2019-05-15 |
| Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency ARALAST NP 60 mg/kg, ARALAST NP 120 mg/kg, GLASSIA 60 mg/kg - Chronic Obstructive Pulmonary Disease, Alpha1-antitrypsin Deficiency | Phase 3 | Terminated | Baxalta now part of Shire | 7 | 2016-11-02 | 2021-05-13 |
| Azithromycin for Acute Exacerbations Requiring Hospitalization Azithromycin, Placebo - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Wim Janssens | 301 | 2014-08-01 | 2018-09-05 |
| A Study in Patients With Chronic Obstructive Pulmonary Disease (FAIR) Foster® 100/6 µg/unit dose, Symbicort® Turbohaler® 200/6 μg/actuation - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Chiesi Farmaceutici S.p.A. | 113 | 2011-09-01 | 2017-03-30 |
| Efficacy of Helium/Oxygen Compared to Air/Oxygen in Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Helium/Oxygen 78%/22%, Air/Oxygen - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Air Liquide Santé International | 446 | 2010-05-01 | 2014-10-07 |
| Safety of Inhaled Human Insulin in Subjects With Diabetes Mellitus and Chronic Obstructive Pulmonary Disease (COPD) inhaled human insulin, insulin aspart - Diabetes, Diabetes Mellitus, Type 1 | Phase 3 | Terminated | Novo Nordisk A/S | 38 | 2007-05-15 | 2017-03-01 |
| Endobronchial Valve for Emphysema PalliatioN Trial (VENT) Cost-effectiveness Sub-Study Emphasys Endobronchial Valve (EBV) Device and Procedure - Emphysema, Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Emphasys Medical | 270 | 2004-12-01 | 2009-08-18 |
| A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With COPD Subcutaneous Insulin, Inhaled Insulin - Diabetes Mellitus, Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Pfizer | 105 | 2003-01-01 | 2010-02-02 |
| Effects of NIMV on the Health Status of Chronic Obstructive Pulmonary Disease (COPD )Patients non-invasive mechanical ventilation - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | University of British Columbia | 40 | 2002-01-01 | 2005-08-17 |
Pulmonary Disease, Chronic Obstructive (14) · Bronchitis, Chronic (2) · Diabetes Mellitus (2) · Hypertension, Pulmonary (2) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Emphysema (1) · Hypertension (1) · Lung Diseases (1) · Smoking Cessation (1) · Vascular Diseases (1) · alpha 1-Antitrypsin Deficiency (1)
Chronic Disease (14) · Disease Attributes (14) · Lung Diseases, Obstructive (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Respiratory Tract Diseases (14) · Lung Diseases (13) · Bronchial Diseases (2) · Bronchitis (2) · Cardiovascular Diseases (2) · Endocrine System Diseases (2) · Glucose Metabolism Disorders (2) · Infections (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2)
Azithromycin (1) · Foster Home Care (1) · Helium (1) · Insulin Aspart (1) · Noninvasive Ventilation (1) · Oxygen (1) · Roflumilast (1) · Varenicline (1) · alpha 1-Antitrypsin (1) · tanimilast (1)
Chiesi Farmaceutici S.p.A. (3) · United Therapeutics (2) · Air Liquide Santé International (1) · Baxalta now part of Shire (1) · Emphasys Medical (1) · Novartis Pharmaceuticals (1) · Novo Nordisk A/S (1) · Pfizer (1) · University of Auckland, New Zealand (1) · University of British Columbia (1) · Wim Janssens (1)
United States (6) · Argentina (4) · Germany (4) · Israel (4) · Netherlands (4) · Canada (3) · Italy (3) · New Zealand (3) · Romania (3) · Slovakia (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Australia (2) · Austria (2) · Belgium (2)
Dirkje Postma, MD (1) · Don D Sin, MD (1) · Klaus F. Rabe, Prof. (1) · Marteen van den Berge, MD (1) · Natalie Walker, PhD (1) · Robert Kaplan, PhD (1) · Wim Janssens, MD. PhD (1)
PMID 27099485, PMID 27736154, PMID 29268739, PMID 31665017, PMID 33060632, PMID 38811045
2023 (1)