Chronic Obstructive Pulmonary Disease: Clinical Trials

1094 completed, 320 unknown, 111 terminated, 81 recruiting. 688 Not applicable, 185 Phase 2, 176 Phase 3, 134 Phase 4, 100 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	688	Completed 428, Unknown 138, Terminated 38, Recruiting 36, Withdrawn 21, Not yet recruiting 14, Active not recruiting 11, Enrolling by invitation 1, Suspended 1
Phase 2	185	Completed 127, Terminated 19, Unknown 15, Recruiting 9, Active not recruiting 6, Withdrawn 5, Not yet recruiting 3, Suspended 1
Phase 3	176	Completed 124, Unknown 17, Terminated 14, Withdrawn 10, Recruiting 5, Not yet recruiting 3, Active not recruiting 2, Enrolling by invitation 1
Phase 4	134	Completed 90, Unknown 25, Withdrawn 7, Recruiting 5, Terminated 5, Not yet recruiting 2
Phase 1	100	Completed 69, Terminated 12, Unknown 8, Recruiting 6, Active not recruiting 2, Withdrawn 2, Not yet recruiting 1
Early Phase 1	15	Completed 7, Terminated 4, Unknown 3, Active not recruiting 1

Follow Chronic Obstructive Pulmonary Disease: new trials by email Literature Review of Chronic Obstructive Pulmonary Disease trials Research Report on Chronic Obstructive Pulmonary Disease

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Developing an Intervention to Optimize Virtual Care Adoption for COPD Management VC-OPTIONS - Chronic Obstructive Pulmonary Disease	Not applicable	Not yet recruiting	VA Office of Research and Development	40	2027-09-02	2026-09-29
Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR) Fluticasone 250mcg/Formoterol 12mcg/Glycopyrronium 25mcg, Comparator - Trimbow® - Chronic Obstructive Pulmonary Disease	Phase 3	Not yet recruiting	Eurofarma Laboratorios S.A.	1252	2027-01-30	2026-10-26
The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD Inhaled Nitric Oxide, Placebo - Chronic Obstructive Pulmonary Disease	Phase 1 / Phase 2	Not yet recruiting	University of Alberta	80	2026-12-01	2026-07-08
Effect of add-on Doxofylline on Lung Function in Stable COPD Doxofylline - Chronic Obstructive Pulmonary Disease	Phase 4	Not yet recruiting	University of Milan	78	2026-12-01	2026-04-29
A Clinical Trial Comparing TQC3927 Inhaled Powder With Glycopyrronium Bromide and Formoterol Inhaled Aerosol (Biovoping® Lingchang®) for the Treatment of Chronic Obstructive Pulmonary Disease TQC3927 inhalation aerosol, Glyceryl bromide/formoterol inhalation aerosol - Chronic Obstructive Pulmonary Disease	Phase 2	Suspended	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	90	2026-12-01	2026-09-03
Firefighter's Longitudinal Airway and Respiratory Exposome/Multiome Study (FLARES) Anosmia, Chronic Obstructive Pulmonary Disease		Enrolling by invitation	National Institute of Allergy and Infectious Diseases (NIAID)	350	2026-11-01	2026-10-27
Effects of TPB-Based Cadence Exercise and Breathing Training on Physiological Parameters and Quality of Life in Patients With COPD Breathing Training, Cadence Exercise, Usual Care - Chronic Obstructive Pulmonary Disease	Not applicable	Recruiting	Fu Jen Catholic University Hospital	200	2026-10-06	2026-10-06
High-Intensity Interval Alternating Concentric-Eccentric Training in Chronic Respiratory Disease Alternating Concentric-Eccentric High-Intensity Interval Training, Concentric High-Intensity Interval Training, Usual Care - Chronic Respiratory Disease, Chronic Obstructive Pulmonary Disease	Not applicable	Not yet recruiting	Fu Jen Catholic University Hospital	45	2026-10-06	2026-10-09
THERMotherapy Against Persistent Bacterial LUNG Infections Thermotherapy/sauna bath - Lung Diseases, Obstructive, Bronchiectasis	Not applicable	Not yet recruiting	Chronic Obstructive Pulmonary Disease Trial Network, Denmark	150	2026-10-01	2026-06-17
A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD) Lunsekimig - Chronic Obstructive Pulmonary Disease	Phase 3	Enrolling by invitation	Sanofi	1508	2026-09-16	2026-10-21
Titrated Ambulatory Oxygen in Fibrotic ILD and COPD With Isolated Exertional Hypoxemia Portable Oxygen Concentrator, Portable compressed oxygen D-tanks, No ambulatory oxygen therapy - Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease	Not applicable	Enrolling by invitation	State University of New York at Buffalo	24	2026-09-02	2026-09-09
ECHO-COPD: Impact of a Pharmacist-Led Health Belief Model-Based Educational Intervention Among Chronic Obstructive Pulmonary Disease Patients Pharmacist-Led HBM-Based Educational Intervention - Medication Adherence, Quality of Life	Not applicable	Not yet recruiting	Rabia Hussain	140	2026-09-01	2026-09-25
Combinaison of Virtual Reality and Rehabilitation to Improve Muscle Function, Exercise Tolerance, Exertional Symptoms and Dyspnea in Patients With Chronic Respiratory Disease: a Randomized Cross-over Trial virtual reality - Chronic Obstructive Pulmonary Disease	Not applicable	Not yet recruiting	Fondation Hôpital Saint-Joseph	26	2026-09-01	2026-08-31
A Personalized Mobile Application Providing Temperature-Related Health Risk Warnings and Protective Recommendations for Patients With Chronic Obstructive Pulmonary Disease Mobile Application-Based Personalized Temperature Health Risk Early Warning Intervention - Chronic Obstructive Pulmonary Disease	Not applicable	Recruiting	Tiantian Li	240	2026-08-04	2026-10-23
Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective Study Chronic Obstructive Pulmonary Disease		Recruiting	Nanfang Hospital, Southern Medical University	2500	2026-08-03	2026-08-13
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease		Recruiting	Fu Jen Catholic University	180	2026-06-29	2026-07-06
Long-term Safety and Tolerability of Tozorakimab in Patients With COPD and History of Exacerbations Tozorakimab Dose Regimen 1, Tozorakimab Dose Regimen 2 - Chronic Obstructive Pulmonary Disease, COPD	Phase 3	Recruiting	AstraZeneca	59	2026-05-05	2026-10-16
CLEAR Model for Predicting Ventilatory Liberation in Severe COPD Chronic Obstructive Pulmonary Disease		Recruiting	Assiut University	400	2026-04-29	2026-05-11
Evaluation of the Inhaled TQC3721 Suspension in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease TQC3721 Suspension for Inhalation - Chronic Obstructive Pulmonary Disease	Phase 3	Recruiting	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	800	2026-04-14	2026-09-28
Inclined Versus Standard Exercise for COPD Patients walking on incline or walking at increasing speed for 36 visits - Chronic Obstructive Pulmonary Disease	Not applicable	Recruiting	VA Office of Research and Development	54	2026-04-01	2026-04-13

Showing 20 of 1729. Sign in to see all of them.

Narrower conditions

Pulmonary Disease, Chronic Obstructive (1729)  ·  Asthma (111)  ·  Dyspnea (89)  ·  Emphysema (89)  ·  Heart Failure (81)  ·  Motor Activity (78)  ·  Lung Diseases (56)  ·  Bronchitis, Chronic (55)  ·  Lung Diseases, Obstructive (47)  ·  Diabetes Mellitus (44)  ·  Hypertension (29)  ·  Hypertension, Pulmonary (28)  ·  Depression (24)  ·  Neoplasms (24)  ·  Respiratory Insufficiency (24)

Broader conditions

Disease Attributes (1729)  ·  Pathologic Processes (1729)  ·  Pathological Conditions, Signs and Symptoms (1729)  ·  Respiratory Tract Diseases (1719)  ·  Chronic Disease (1716)  ·  Lung Diseases, Obstructive (1682)  ·  Lung Diseases (1673)  ·  Bronchial Diseases (187)  ·  Signs and Symptoms (166)  ·  Respiration Disorders (164)  ·  Behavior (136)  ·  Cardiovascular Diseases (134)  ·  Immune System Diseases (128)  ·  Signs and Symptoms, Respiratory (120)  ·  Hypersensitivity (114)

Interventions

Formoterol Fumarate (52)  ·  Tiotropium Bromide (51)  ·  Glycopyrrolate (35)  ·  indacaterol (28)  ·  Budesonide (27)  ·  Salmeterol Xinafoate (27)  ·  Albuterol (23)  ·  Exercise (21)  ·  Noninvasive Ventilation (19)  ·  Fluticasone (17)  ·  Fluticasone-Salmeterol Drug Combination (14)  ·  Inhalation (14)  ·  Roflumilast (14)  ·  aclidinium bromide (14)  ·  Oxygen (13)

Sponsors

AstraZeneca (95)  ·  Novartis Pharmaceuticals (42)  ·  Chiesi Farmaceutici S.p.A. (33)  ·  National Heart, Lung, and Blood Institute (NHLBI) (26)  ·  Riphah International University (24)  ·  Schön Klinik Berchtesgadener Land (21)  ·  China-Japan Friendship Hospital (18)  ·  Imperial College London (18)  ·  Pearl Therapeutics, Inc. (17)  ·  University of Zurich (16)  ·  Laval University (15)  ·  Novartis (15)  ·  Brigham and Women's Hospital (14)  ·  KU Leuven (14)  ·  ADIR Association (12)

Countries

United States (397)  ·  United Kingdom (198)  ·  Germany (143)  ·  Canada (136)  ·  China (136)  ·  France (134)  ·  Spain (89)  ·  Italy (76)  ·  Netherlands (66)  ·  Belgium (65)  ·  Denmark (59)  ·  Brazil (58)  ·  Turkey (Türkiye) (57)  ·  Poland (53)  ·  South Korea (48)

Top investigators

Esther Garcia, MD (8)  ·  Sidra Afzal, PP-DPT (8)  ·  Talant M Sooronbaev, MD (8)  ·  David Debeaumont, MD (7)  ·  Konrad E Bloch, MD (7)  ·  Catherine Tardif, MD (6)  ·  Catherine Viacroze, MD (6)  ·  Colin Reisner, M.D. (6)  ·  Francis-Edouard Gravier, PT (6)

Results publications

PMID 34495549, PMID 37542951, PMID 33511633, PMID 42149813, PMID 42551404, PMID 25670896, PMID 29331313, PMID 39423760, PMID 14999112, PMID 15539711, PMID 16055882, PMID 16267363, PMID 17273586, PMID 17507545, PMID 19179484, PMID 19880908, PMID 20920189, PMID 21272339, PMID 22003288, PMID 22075481, PMID 22177371, PMID 22206353, PMID 22280813, PMID 22383665, PMID 22465313, PMID 22654006, PMID 22721944, PMID 22927751, PMID 23020650, PMID 23377993, PMID 24156566, PMID 24432712, PMID 24484754, PMID 24622644, PMID 25066329, PMID 25287629, PMID 26024688, PMID 26430763, PMID 27117828, PMID 27736154, PMID 27940278, PMID 28069009, PMID 28419462, PMID 28668356, PMID 28993871, PMID 29268739, PMID 29650248, PMID 29975735, PMID 30340648, PMID 30573441

NIH funding

2009 (10), 2017 (10), 2015 (6), 2018 (6), 2023 (6), 2008 (4), 2016 (4), 2019 (4), 2025 (4), 2014 (2), R01HL093081 (2), R33AT009991 (2), 1IK2HX003532-01A2 (1), 1UG3HL155806-01A1 (1), 2005 (1)