266 completed, 12 terminated, 11 unknown, 6 withdrawn. 95 Phase 3, 76 Phase 4, 52 Phase 2, 29 Phase 1, 9 Not applicable.
Follow Tiotropium Bromide: new trials by email Literature Review of Tiotropium Bromide trials Research Report on Tiotropium Bromide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PREterm Infants With Bronchial Obstruction - Prospective Study of Efficacy and Safety of Inhaled Tiotropium tiotropium bromide (Spiriva Respimat) - Bronchial Obstruction, Premature Birth | Phase 4 | Not yet recruiting | General University Hospital, Prague | 50 | 2026-11-01 | 2026-09-18 |
| A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TQC3302 Inhalation Spray in Healthy Adult Subjects TQC3302 inhalation spray, TQC3302 inhalation spray+Tiotropium bromide and olodaterol hydrochloride inhalation spray +Budesonide Powder for Inhalation, Tiotropium bromide and olodaterol hydrochloride inhalation spray +Budesonide Powder for Inhalation+ TQC3302 inhalation spray - Chronic Obstructive Pulmonary Disease | Phase 1 | Terminated | Chia Tai Tianqing Pharmaceutical (Guangzhou) Co., Ltd. | 33 | 2025-11-25 | 2026-08-27 |
| Evaluating the Impact of Single Dose Tiotropium on Allergen-induced Early Asthmatic Response Tiotropium (Spiriva®), Placebo - Asthma Bronchiale | Phase 4 | Not yet recruiting | University of Saskatchewan | 10 | 2025-01-01 | 2024-11-07 |
| Comparative Efficacy of Once-daily LAMA/LABA Combinations Versus Tiotropium on Constant-work-rate Cycle Endurance in COPD Tiotropium, Olodaterol, Umeclidinium - COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Suspended | Medical University of Bialystok | 100 | 2024-03-11 | 2026-10-02 |
| ANTES B+ Clinical Trial Trelegy Ellipta 100/62.5/25Mcg Inh 30D, Brimica, Duaklir - Chronic Obstructive Pulmonary Disease | Phase 4 | Terminated | Fundacio Privada Mon Clinic Barcelona | 48 | 2024-02-29 | 2025-08-14 |
| Effect of Tiotropium on Eye Findings in the Treatment of Chronic Obstructive Pulmonary Disease Tiotropium - Chronic Obstructive Pulmonary Disease, Glaucoma, Angle-Closure | Completed | Giresun University | 108 | 2023-10-23 | 2024-07-29 | |
| Tiotropium Handihaler vs. Tiotropium Respimat in COPD tiotropium bromide inhalation powder (Spiriva HandiHaler), tiotropium bromide (Spiriva Respimat), Hyperpolarized 129XeMRI - Chronic Obstructive Pulmonary Disease (COPD) | Phase 2 | Withdrawn | Duke University | 2023-05-01 | 2023-06-15 | |
| Open Label Study to Assess the Effect of Patient Use and Robustness of Tiotropium 18ug Inhalation Powder, Hard Capsule,Zephir Inhaler Device Tiotropium 18 µg inhalation powder, hard capsule, Zephir inhaler - COPD | Phase 1 | Completed | Xiromed LLC | 116 | 2022-10-03 | 2024-02-12 |
| Effectiveness of Tiotropium + Olodaterol Versus Inhaled Corticosteroids (ICS) + Long-acting β2-agonists (LABA) Among COPD Patients in Taiwan Tiotropium (Tio), Inhaled corticosteroids (ICS), Olodaterol (Olo) - Pulmonary Disease, Chronic Obstructive | Completed | Boehringer Ingelheim | 17018 | 2022-09-30 | 2024-08-09 | |
| Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD) Test Product - Tiotropium Bromide Inhalation Powder 18 mcg, Spiriva Handihaler (Tiotropium Bromide) 18 mcg, Placebo - COPD | Phase 3 | Completed | Xiromed LLC | 335 | 2022-08-17 | 2024-01-31 |
| Assessment of Health-related Quality of Life After Switching COPD Patients From a Dry Powder Inhaler to a Soft Mist Inhaler Remaining on the Same Inhalative Drug Spiriva® Respimat®, Spiriva® HandiHaler®, Tiotropium bromide - Pulmonary Disease, Chronic Obstructive | Terminated | Boehringer Ingelheim | 9 | 2022-08-05 | 2025-02-26 | |
| Bioequivalence Study of Tiotropium Bromide Inhalation Powder Test Product (tiotropium bromide inhalation powder), 18 mcg of Spiriva (Reference Product), Placebo - COPD | Phase 3 | Completed | Phargentis SA | 306 | 2022-03-24 | 2023-04-10 |
| Phase 4 COPD and Suboptimal Inspiratory Flow Rate Revefenacin, Tiotropium, Revefenacin Placebo - Chronic Obstructive Pulmonary Disease | Phase 4 | Completed | Theravance Biopharma | 404 | 2022-01-07 | 2024-12-20 |
| Tiotropium vs. Inhaled Corticosteroids in Children With Nonatopic Asthma Pilot Study (TioNAAP) Tiotropium Bromide - Asthma in Children | Phase 2 | Terminated | Nemours Children's Clinic | 11 | 2022-01-01 | 2025-12-23 |
| A Study in the US Based on Pharmacy and Medical Claims That Compares How Well Stiolto® and Trelegy® Work in People With Chronic Obstructive Pulmonary Disease (COPD) Trelegy Ellipta, Stiolto Respimat, Tiotropium + Olodaterol (5/5 mcg) - Pulmonary Disease, Chronic Obstructive | Completed | Boehringer Ingelheim | 9117 | 2021-12-17 | 2023-10-19 | |
| Regular Use Tiotropium and Tolerance to Bronchoprotection in Mild Asthma Tiotropium Bromide, Matching placebo - Asthma | Phase 4 | Completed | University of Saskatchewan | 12 | 2021-12-13 | 2022-05-23 |
| Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD LABA, LAMA - Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | Erasme University Hospital | 30 | 2021-06-15 | 2023-07-03 |
| Exacerbation Risk in Asthma tiotropium, long-acting β2-agonists (LABA), inhaled corticosteroids (ICS) - Asthma | Completed | Boehringer Ingelheim | 1899 | 2021-05-14 | 2024-04-01 | |
| A Study Using US Medical and Pharmacy Claim Records to Compare the Resource Use, Cost, and Outcomes of People With COPD Who Take Either Tiotropium + Olodaterol or Fluticasone + Umeclidinium + Vilanterol Trelegy Ellipta, Stiolto Respimat, Furoate/Umeclidinium/Vilanterol - Pulmonary Disease, Chronic Obstructive | Completed | Boehringer Ingelheim | 11316 | 2021-02-26 | 2023-11-13 | |
| Quality of Life in Chronic Obstructive Pulmonary Disease (COPD) Patients After Switching to Tiotropium Plus Olodaterol Fixed Dose Combination in Greece Tiotropium bromide plus Olodaterol - Pulmonary Disease, Chronic Obstructive | Completed | Boehringer Ingelheim | 1396 | 2021-02-16 | 2024-06-25 |
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Pulmonary Disease, Chronic Obstructive (242) · Asthma (32) · Emphysema (7) · Dyspnea (6) · Bronchitis, Chronic (5) · Motor Activity (5) · Respiratory Aspiration (5) · Cardiovascular Diseases (2) · Inflammation (2) · Lung Diseases, Obstructive (2) · Smoking (2) · Spinal Cord Injuries (2) · Airway Obstruction (1) · Airway Remodeling (1) · Bronchial Hyperreactivity (1)
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PMID 36472162, PMID 31319851, PMID 32462607, PMID 32671684, PMID 32943047, PMID 27796912, PMID 30261995, PMID 32776202, PMID 11019457, PMID 16322646, PMID 16799080, PMID 17310045, PMID 17951621, PMID 18625750, PMID 18836213, PMID 20075384, PMID 20920365, PMID 21428765, PMID 22544891, PMID 22938706, PMID 24835833, PMID 25342898, PMID 25496316, PMID 25573406, PMID 26112656, PMID 26320402, PMID 27316465, PMID 27993292, PMID 28424359, PMID 29174062, PMID 29355547, PMID 32343967, PMID 32848379, PMID 32848380, PMID 33175291, PMID 38560416, PMID 8810608, PMID 10569435, PMID 12114338, PMID 15663976, PMID 16055868, PMID 16144890, PMID 16310554, PMID 16396956, PMID 16844726, PMID 16914336, PMID 17088091, PMID 17475459, PMID 17532532, PMID 17605774
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