4 completed, 4 unknown. 8 Phase 2, 3 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 4, Unknown 4 |
| Phase 3 | 3 | Unknown 2, Completed 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
Follow Cardiac Output, Low: new trials by email Literature Review of Cardiac Output, Low trials Research Report on Cardiac Output, Low
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS) Levosimendan, Placebos - Cardiac Output, Low | Phase 2 / Phase 3 | Unknown | María de los Ángeles Tena Pajuelo | 300 | 2020-06-17 | 2020-07-24 |
| Autologous Umbilical Cord Blood Treatment of Neonate With CHD Autlogous UCB infusion - Congenital Heart Disease, Brain Injuries | Phase 1 / Phase 2 | Unknown | Sheba Medical Center | 60 | 2019-02-01 | 2021-01-20 |
| Two Inodilators Postsurgery in Neonates Milrinone, Levosimendan - Low Cardiac Output Syndrome | Phase 1 / Phase 2 | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz | 20 | 2009-11-01 | 2012-04-12 |
| Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy Perhexiline, Placebo marked PEXSIG - Myocardial Reperfusion Injury, Cardiac Output, Low | Phase 2 / Phase 3 | Unknown | University Hospital Birmingham | 220 | 2009-10-01 | 2011-08-11 |
| Levosimendan Administration in Neonates With Transposition of the Great Arteries levosimendan, placebo - Low Cardiac Output Syndrome | Phase 2 | Completed | Bambino Gesù Hospital and Research Institute | 63 | 2009-01-01 | 2012-06-26 |
| Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in Infants Levosimendan, Milrinone - Low Cardiac Output Syndrome | Phase 2 | Unknown | Ludwig Boltzmann Gesellschaft | 40 | 2007-09-01 | 2007-10-25 |
| Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery Perhexiline, Placebo marked PEXSIG - Myocardial Reperfusion Injury, Cardiac Output, Low | Phase 2 / Phase 3 | Completed | University Hospital Birmingham | 290 | 2007-02-01 | 2010-05-20 |
| Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease Hydrocortisone, Placebo - Cardiac Output, Low | Phase 2 | Completed | Baylor College of Medicine | 18 | 2003-02-01 | 2016-05-26 |
Heart Defects, Congenital (3) · Myocardial Reperfusion Injury (2) · Aortic Valve Stenosis (1) · Brain Injuries (1) · Hypertrophy, Left Ventricular (1) · Infant, Newborn, Diseases (1) · Transposition of Great Vessels (1)
Cardiovascular Diseases (8) · Heart Diseases (8) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Cardiovascular Abnormalities (4) · Congenital Abnormalities (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Cardiomyopathies (2) · Myocardial Ischemia (2) · Pathologic Processes (2) · Postoperative Complications (2) · Reperfusion Injury (2) · Vascular Diseases (2) · Aortic Valve Disease (1) · Brain Diseases (1)
Simendan (4) · Milrinone (2) · Perhexiline (2) · Adrenal Cortex Hormones (1) · Hydrocortisone (1) · Sodium Chloride (1) · Steroids (1)
University Hospital Birmingham (2) · Bambino Gesù Hospital and Research Institute (1) · Baylor College of Medicine (1) · Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz (1) · Ludwig Boltzmann Gesellschaft (1) · María de los Ángeles Tena Pajuelo (1) · Sheba Medical Center (1)
Spain (2) · United Kingdom (2) · Austria (1) · Israel (1) · Italy (1) · United States (1)
Domeinco Pagano, MD FRCS (2) · Adelina Pellicer, PhD (1) · Anna Hofer, MD (1) · Carlos Labrandero, MD (1) · Elisabet B Berastegui Garcia, Cardiac surgery (1) · Evelyn Lechner, MD (1) · Gemma S Sanchez Espin, Cardiac Surgery (1) · Gerald Tulzer, MD, PHD (1) · Hans Gombotz, MD, PHD (1) · Heather A Dickerson, MD (1)
PMID 19700350, PMID 23620700, PMID 23771484, PMID 24126568, PMID 24948413, PMID 29718383, PMID 33045104
2019 (1)