20 terminated. 20 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Terminated 20 |
| Phase 2 | 3 | Terminated 3 |
Follow Bronchitis: new trials by email Literature Review of Bronchitis trials Research Report on Bronchitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER) Experimental: CHF6001 1600µg, Experimental: CHF6001 3200µg, Placebo - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Chiesi Farmaceutici S.p.A. | 4710 | 2021-07-14 | 2025-12-17 |
| A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) CHF6001 1600µg, CHF6001 3200µg, Placebo - Chronic Obstructive Pulmonary Disease | Phase 3 | Terminated | Chiesi Farmaceutici S.p.A. | 3973 | 2021-07-12 | 2026-02-02 |
| Efficacy of Fluticasone Propionate Associated With Salmeterol Using Inhalation Chamber Versus Placebo to Improve the Respiratory Function in Children Over Six Years of Age Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation With a Decline of FEV1 ≥10% From Pre Transplantation Seretide, Placebo - Stem Cell Transplant Complications, Respiratory Disease | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 35 | 2021-05-21 | 2025-09-16 |
| Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3) Liposomal Cyclosporine A 5 mg, Liposomal Cyclosporine A 10 mg - Bronchiolitis Obliterans, Obliterative Bronchiolitis | Phase 3 | Terminated | Zambon SpA | 164 | 2020-03-12 | 2026-04-07 |
| GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease Itacitinib, Placebo, Methylprednisolone - Chronic Graft-versus-host Disease | Phase 2 / Phase 3 | Terminated | Incyte Corporation | 155 | 2019-01-17 | 2025-10-20 |
| Efficacy and Safety of Curosurf® in Patients Invasively Ventilated for Severe Bronchiolitis Under 12 Months of Age Curosurf 80Mg/Ml Intratracheal Suspension, Ambient Air - Bronchiolitis, Viral | Phase 3 | Terminated | Azienda Ospedaliera Universitaria Integrata Verona | 9 | 2019-01-09 | 2021-04-15 |
| Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies. 0.9% saline solution, oral betamethasone placebo, adrenaline - Children, Bronchiolitis | Phase 2 / Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 195 | 2015-10-01 | 2017-09-12 |
| Post-hospitalisation Nutritional Support and Gait Speed in COPD Food fortification, Oral Nutritional Supplements - Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases | Phase 3 | Terminated | Royal Brompton & Harefield NHS Foundation Trust | 22 | 2014-01-01 | 2015-11-02 |
| The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation CB-5945, Placebo - Opioid-Induced Constipation | Phase 3 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 44 | 2013-07-02 | 2018-11-15 |
| Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation CB-5945, Placebo - Opioid-Induced Constipation | Phase 3 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 61 | 2013-05-20 | 2018-11-15 |
| Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation CB-5945, Placebo - Opioid-Induced Constipation | Phase 3 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 49 | 2013-04-07 | 2018-11-15 |
| Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation CB-5945, Placebo - Opioid-Induced Constipation | Phase 3 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 1407 | 2012-10-12 | 2018-11-15 |
| Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) Inhalation - Bronchiolitis Obliterans | Phase 3 | Terminated | Pari Pharma GmbH | 14 | 2012-02-01 | 2015-04-14 |
| A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis CP-690,550 - Psoriasis | Phase 3 | Terminated | Pfizer | 2867 | 2010-09-01 | 2017-06-26 |
| CIS001 Extension Study of Cyclosporine Inhalation Solution Cyclosporine Inhalation Solution (CIS) - Lung Transplant | Phase 3 | Terminated | APT Pharmaceuticals, Inc. | 17 | 2009-12-01 | 2012-09-17 |
| L-CsA in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant (LT) Patients Cyclosporine Inhalation Solution - Bronchiolitis Obliterans | Phase 2 / Phase 3 | Terminated | Pari Pharma GmbH | 130 | 2009-12-01 | 2015-04-14 |
| Local Anesthetic Infusion and Sternotomy Local anesthetic (Ropivacaine), Saline - Hyperalgesia, Pain | Phase 3 | Terminated | University Hospital, Bordeaux | 21 | 2009-02-01 | 2011-12-13 |
| High-dose Ribavirin in Treatment of Chronic Hepatitis C Genotype 1 or 4 ribavirin - Chronic Hepatitis C | Phase 3 | Terminated | Foundation for Liver Research | 110 | 2008-04-01 | 2014-07-14 |
| Dynepo Infrequent Dosing Study Dynepo (Epoetin delta), Dynepo - Anemia, Kidney Failure | Phase 3 | Terminated | Shire | 407 | 2006-10-30 | 2021-06-14 |
| A Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis Faropenem medoxomil, placebo - Chronic Bronchitis | Phase 3 | Terminated | Replidyne | 491 | 2005-12-01 | 2008-06-03 |
Bronchiolitis Obliterans Syndrome (11) · Bronchiolitis Obliterans (5) · Pain (5) · Bronchitis, Chronic (4) · Constipation (4) · Opioid-Induced Constipation (4) · Pulmonary Disease, Chronic Obstructive (3) · Anemia (1) · Bronchiolitis (1) · Bronchiolitis, Viral (1) · Graft vs Host Disease (1) · Hepatitis C (1) · Hepatitis C, Chronic (1) · Hyperalgesia (1)
Bronchial Diseases (20) · Lung Diseases (20) · Lung Diseases, Obstructive (19) · Respiratory Tract Diseases (19) · Bronchiolitis (15) · Immune System Diseases (11) · Organizing Pneumonia (11) · Pathological Conditions, Signs and Symptoms (11) · Graft vs Host Disease (10) · Bronchiolitis Obliterans (9) · Infections (7) · Pathologic Processes (7) · Respiratory Tract Infections (6) · Chronic Disease (5)
Anesthetics, Local (1) · Betamethasone (1) · Dietary Supplements (1) · Epinephrine (1) · Erythropoietin (1) · Fluticasone-Salmeterol Drug Combination (1) · INCB039110 (1) · Inhalation (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Particulate Matter (1) · Prednisone (1) · Ribavirin (1) · Roflumilast (1) · Ropivacaine (1)
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Assistance Publique - Hôpitaux de Paris (2) · Chiesi Farmaceutici S.p.A. (2) · Pari Pharma GmbH (2) · APT Pharmaceuticals, Inc. (1) · Azienda Ospedaliera Universitaria Integrata Verona (1) · Foundation for Liver Research (1) · Incyte Corporation (1) · Pfizer (1) · Replidyne (1) · Royal Brompton & Harefield NHS Foundation Trust (1) · Shire (1) · University Hospital, Bordeaux (1) · Zambon SpA (1)
Germany (8) · France (7) · United Kingdom (7) · United States (7) · Austria (6) · Spain (6) · Belgium (4) · Greece (4) · Israel (4) · Italy (4) · Netherlands (4) · Poland (4) · Argentina (3) · Bosnia and Herzegovina (3) · Bulgaria (3)
Bruce A Johnson, MD (1) · Claus Neurohr, MD (1) · J PH Drenth, MD PhD (1) · Jeffrey Golden, MD (1) · Klaus F. Rabe, Prof. (1) · Paola R Castellani, MD (1) · Paolo Biban, MD (1) · R J de Knegt, MD PhD (1)
PMID 17999759, PMID 29782642, PMID 32816215, PMID 33077567, PMID 36777695, PMID 36791280, PMID 38696034
2008 (1), 2015 (1), 2018 (1), 2019 (1), 2023 (1)