366 completed, 105 terminated, 83 recruiting, 52 active not recruiting. 691 Phase 1, 195 Phase 2.
Follow Brain Neoplasms: new trials by email Literature Review of Brain Neoplasms trials Research Report on Brain Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2027-01-01 | 2026-10-30 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-10-30 |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera - Brain Tumor | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-12-01 | 2026-09-29 |
| OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma CT-179 - Recurrent Glioblastoma, Newly Diagnosed MGMT Unmethylated Glioblastoma | Phase 1 | Not yet recruiting | Olivia Newton-John Cancer Research Institute | 54 | 2026-12-01 | 2026-10-28 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| A Study of SRN-101 Administered Prior to Surgical Resection in Adults With Recurrent High-Grade Glioma. SRN-101, Blood Specimen Collection, Surgical Resection - Recurrent High-Grade Gliomas, Brain Neoplasm | Phase 1 | Not yet recruiting | Nicholas Butowski | 6 | 2026-11-15 | 2026-10-27 |
| A Phase I Clinical Study of YN003 in the Treatment of Glioma YN003 Injection - Glioma, Glioblastoma | Phase 1 | Recruiting | Beijing Inno Medicine Co., Ltd. | 50 | 2026-10-27 | 2026-11-10 |
| IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, CD70 IHC assay - Brain Metastases | Phase 1 | Recruiting | University of Florida | 12 | 2026-10-13 | 2026-10-16 |
| Study of Zanzalintinib in Children and Adolescents With Relapsed or Refractory Solid Tumors Zanzalintinib - Cancer, Pediatric Cancer | Phase 1 | Not yet recruiting | Exelixis | 18 | 2026-09-30 | 2026-08-19 |
| A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors NEO100 - Pediatric Tumor of CNS, Pediatric Tumor of Brain | Phase 1 | Recruiting | Neonc Technologies, Inc. | 12 | 2026-09-08 | 2026-09-15 |
| A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab Computed Tomography, Copper Cu 64-DOTA-pembrolizumab, Low Dose Radiation Therapy - Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2026-09-01 | 2026-10-19 |
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC) 203Pb-RMX-VHPIB injection, SPECT/CT Imaging - Glioblastoma Multiforme (GBM), Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 | Recruiting | Radiomedix, Inc. | 20 | 2026-08-15 | 2026-08-07 |
| Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma LMP744, Conventional Surgery or Biopsy - Recurrent Glioblastoma, Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Phase 1 / Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2026-07-15 | 2026-10-16 |
Showing 20 of 691. Sign in to see all of them.
Glioblastoma (288) · Glioma (235) · Astrocytoma (205) · Central Nervous System Neoplasms (170) · Gliosarcoma (155) · Oligodendroglioma (149) · Medulloblastoma (94) · Neoplasms (75) · Diffuse Intrinsic Pontine Glioma (71) · Ependymoma (68) · Breast Neoplasms (49) · Choroid Plexus Neoplasms (44) · Melanoma (42) · Carcinoma, Non-Small-Cell Lung (41)
Nervous System Diseases (686) · Nervous System Neoplasms (685) · Neoplasms by Site (684) · Brain Diseases (683) · Central Nervous System Diseases (681) · Neoplasms (616) · Central Nervous System Neoplasms (521) · Neoplasms by Histologic Type (487) · Neoplasms, Nerve Tissue (474) · Neuroectodermal Tumors (472) · Neoplasms, Germ Cell and Embryonal (465) · Neoplasms, Glandular and Epithelial (458) · Neoplasms, Neuroepithelial (442) · Glioma (205) · Astrocytoma (131)
Temozolomide (77) · Radiotherapy (39) · Radiosurgery (35) · Bevacizumab (24) · Carboplatin (22) · Irinotecan (19) · Radiation (17) · pembrolizumab (17) · Cyclophosphamide (16) · Erlotinib Hydrochloride (15) · Magnetic Resonance Spectroscopy (15) · Filgrastim (14) · Carmustine (12) · Etoposide (12) · Surgical Procedures, Operative (12)
National Cancer Institute (NCI) (85) · M.D. Anderson Cancer Center (28) · Duke University (19) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (18) · City of Hope Medical Center (14) · Memorial Sloan Kettering Cancer Center (14) · University of Florida (12) · Pediatric Brain Tumor Consortium (11) · Children's Oncology Group (10) · Case Comprehensive Cancer Center (9) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (9) · Dana-Farber Cancer Institute (8) · Emory University (8) · H. Lee Moffitt Cancer Center and Research Institute (8) · Jonsson Comprehensive Cancer Center (8)
United States (576) · Canada (38) · China (27) · France (25) · Australia (23) · Spain (19) · United Kingdom (18) · Italy (13) · Germany (11) · Netherlands (11) · Switzerland (9) · South Korea (8) · Belgium (7) · Denmark (7) · Israel (6)
Henry S. Friedman, MD (7) · Darell D. Bigner, MD, PhD (6) · Wenyin Shi, MD, PhD (6) · John Boockvar, MD (5) · Annick Desjardins, MD (4) · Asha Das, MD (4) · David A. Reardon, MD (4) · Howard A. Fine, MD (4) · Jana Portnow (4) · Stuart A. Grossman, MD (4) · Timothy F. Cloughesy, MD (4) · Annick Desjardins, MD, FRCPC (3) · Ashley Ghiaseddin, MD (3) · David Peereboom, MD (3)
PMID 23377664, PMID 23545055, PMID 41218853, PMID 11410496, PMID 12721262, PMID 12749708, PMID 14670747, PMID 14769136, PMID 14769140, PMID 15292713, PMID 15758009, PMID 16012795, PMID 16061868, PMID 16170172, PMID 16192602, PMID 16234526, PMID 16533779, PMID 16533878, PMID 16877733, PMID 16914576, PMID 16914578, PMID 17264335, PMID 17278121, PMID 17470857, PMID 17634493, PMID 17694310, PMID 17941066, PMID 17987262, PMID 18048828, PMID 18056189, PMID 18056194, PMID 18094423, PMID 18215105, PMID 18281544, PMID 18281546, PMID 18359865, PMID 18470481, PMID 18477765, PMID 18497327, PMID 19065567, PMID 19075272, PMID 19223865, PMID 19248046, PMID 19289491, PMID 19430790, PMID 19768386, PMID 20044751, PMID 20049936, PMID 20460632, PMID 20479675
U01CA081457 (10), P30CA033572 (8), U01CA137443 (7), U01CA097452 (5), UM1CA081457 (5), UM1CA097452 (5), 2023 (4), U01CA062399 (4), U01CA062475 (4), P30CA016672 (3), P30CA138292 (3), U10CA025224 (3), UM1CA186691 (3), 2009 (2), 2015 (2)