4 recruiting, 3 completed, 2 unknown, 2 withdrawn. 11 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Recruiting 4, Completed 3, Unknown 2, Withdrawn 2 |
| Phase 2 | 1 | Recruiting 1 |
Follow Asphyxia Neonatorum: new trials by email Literature Review of Asphyxia Neonatorum trials Research Report on Asphyxia Neonatorum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intrapartum Sildenafil in Laboring Mothers Sildenafil 50 mg Oral Tablet, Placebo Oral Tablet - Neonatal Asphyxia, Intrapartum Fetal Distress | Phase 3 | Withdrawn | University of Alabama at Birmingham | 2025-05-01 | 2025-09-16 | |
| Oral Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings Sildenafil 50 mg Oral Tablet, Placebo Oral Tablet - Intrapartum Fetal Distress, Neonatal Asphyxia | Phase 3 | Withdrawn | University of Alabama at Birmingham | 2025-05-01 | 2025-09-16 | |
| Cooling in Mild Encephalopathy Whole body hypothermia, Targeted normothermia, Supportive neonatal intensive care - Neonatal Encephalopathy, Newborn Asphyxia | Phase 3 | Recruiting | Imperial College London | 426 | 2024-03-15 | 2026-02-06 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia RLS-0071, Placebo - Hypoxic-Ischemic Encephalopathy | Phase 2 / Phase 3 | Recruiting | ReAlta Life Sciences, Inc. | 173 | 2023-07-27 | 2026-11-05 |
| Erythropoietin for Neonatal Encephalopathy in LMIC (EMBRACE Trial) Erythropoietin, Supportive neonatal intensive care - Encephalopathy, Erythropoietin | Phase 3 | Recruiting | Imperial College London | 504 | 2022-12-31 | 2024-03-19 |
| Effect of Intrapartum Oxygen Administration on Fetal and Early Neonatal Outcomes 100% Oxygen, 21% oxygen - Fetal Distress, Birth Asphyxia | Phase 3 | Unknown | Makerere University | 1108 | 2020-03-16 | 2020-03-26 |
| Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment Probiotic mixture, Placebo - Asphyxia Neonatorum, Morbidity;Newborn | Phase 3 | Unknown | Policlinico Hospital | 120 | 2020-01-01 | 2019-10-31 |
| Citicoline as Neuroprotector in Neonates Exposed to Hypoxia Citicoline, Placebo - Neonatal Hypoxia | Phase 3 | Recruiting | Sherief Abd-Elsalam | 40 | 2019-02-01 | 2019-05-29 |
| High-dose Erythropoietin for Asphyxia and Encephalopathy Normal saline placebo, Erythropoietin - Neonatal Encephalopathy, Birth Asphyxia | Phase 3 | Completed | University of California, San Francisco | 500 | 2017-01-01 | 2023-01-30 |
| Oxygen Toxicity in the Resuscitation in Extremely Premature Infants Resuscitation - Birth Asphyxia, Premature Birth | Phase 3 | Completed | Fundacion Para La Investigacion Hospital La Fe | 88 | 2005-04-01 | 2008-10-15 |
| Neonatal Resuscitation in Zambia Neonatal Resuscitation - Asphyxia Neonatorum, Neonatal Mortality | Phase 3 | Completed | NICHD Global Network for Women's and Children's Health | 40000 | 2004-10-01 | 2014-07-31 |
Asphyxia (2) · Hypoxia-Ischemia, Brain (2) · Brain Diseases (1) · Cerebral Palsy (1) · Fetal Distress (1) · Premature Birth (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Infant, Newborn, Diseases (11) · Pathological Conditions, Signs and Symptoms (4) · Central Nervous System Diseases (3) · Nervous System Diseases (3) · Signs and Symptoms (3) · Brain Diseases (2) · Brain Ischemia (2) · Cardiovascular Diseases (2) · Cerebrovascular Disorders (2) · Death (2) · Hypoxia (2) · Hypoxia, Brain (2) · Pathologic Processes (2) · Signs and Symptoms, Respiratory (2)
Erythropoietin (2) · Sildenafil Citrate (2) · Tablets (2) · Aging (1) · Air (1) · Cytidine Diphosphate Choline (1) · Epoetin Alfa (1) · Oxygen (1) · RLS-0071 (1) · Resuscitation (1)
Imperial College London (2) · University of Alabama at Birmingham (2) · Fundacion Para La Investigacion Hospital La Fe (1) · Makerere University (1) · NICHD Global Network for Women's and Children's Health (1) · Policlinico Hospital (1) · ReAlta Life Sciences, Inc. (1) · Sherief Abd-Elsalam (1) · University of California, San Francisco (1)
Italy (2) · United States (2) · Zambia (2) · Bangladesh (1) · Cameroon (1) · Egypt (1) · India (1) · Kenya (1) · Nigeria (1) · Spain (1) · Sri Lanka (1) · Uganda (1) · United Kingdom (1)
Waldemar A Carlo, MD (3) · Sudhin Thayyil, PhD (2) · Abeer Salamah, Lecturer (1) · Elwyn Chomba, MBChB, DCH, MRCP (1) · James K Tumwine, PhD (1) · Maximo Vento, Phd, Md (1) · May R Elsheikh, Lecturer (1) · Sandra Juul, MD PHD (1) · Seetha Shankaran, MD (1) · Yvonne Wu, MD MPH (1)
PMID 18450889, PMID 34144032, PMID 35830641, PMID 37019334, PMID 37173784, PMID 37418263, PMID 37698478, PMID 37742617, PMID 38006967, PMID 38360261, PMID 38729748, PMID 38984984, PMID 39026197, PMID 42386129
U01HD043464 (1)