34 completed, 31 unknown, 9 not yet recruiting, 9 recruiting. 52 Not applicable, 6 Phase 1, 4 Phase 2, 4 Phase 3, 2 Early Phase 1.
Follow Anal Fistula: new trials by email Literature Review of Anal Fistula trials Research Report on Anal Fistula
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanical Bowel Preparation Prior To Sphincter-Sparing Surgery For Complex Anal Fistulae Mechanical bowel preparation - Anal Fistula, Rectal Fistula | Not applicable | Not yet recruiting | Region Skane | 116 | 2026-11-01 | 2026-10-27 |
| Antibiotics After Incision and Drainage to Prevent Fistula Formation After First Episode of Perianal Abscess Amoxicillin + Clavulanate, Ciprofloxacin + Metronidazole - Perianal Abscess, Anal Fistula | Phase 4 | Not yet recruiting | University of Illinois at Chicago | 236 | 2026-10-05 | 2026-09-21 |
| The Use of Electronic Bidets Compared to Water Rinsing After Surgery for Anal Fistula or Haemorrhoidal Disease: a Pilot Study Electronic bidet, standard water rinsing - Anal Fistula Surgery, Anal Fistula | Not applicable | Recruiting | Universitair Ziekenhuis Brussel | 40 | 2026-10-01 | 2026-10-15 |
| Impact of Preoperative Bowel Preparation on Healing Outcomes in FiLaC Bowel preparation before fistula laser closure (FiLaC) surgery - Anal Fistula, Fistula in Ano | Not yet recruiting | Acibadem Kent Hospital | 100 | 2026-10-01 | 2026-09-02 | |
| Early Neuroanatomically-Guided Electroacupuncture for Postoperative Pain and Urinary Retention After Anorectal Surgery: A Pilot Study Electroacupuncture, Standard Multimodal Analgesia - Postoperative Pain, Urinary Retention | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 35 | 2026-07-07 | 2026-11-13 |
| Laser Ablation Versus Conventional Fistulectomy for Uncomplicated Perianal Fistula Laser ablation, Conventional Open Fistulectomy - Perianal Fistula, Anal Fistula | Not applicable | Not yet recruiting | PNS Hafeez - Naval Hospital | 72 | 2026-07-01 | 2026-07-02 |
| Impact of Surgical Timing on Anal Fistula Outcomes Anal Fistula Surgery, Anal Fistula | Not yet recruiting | Assiut University | 90 | 2026-05-01 | 2026-03-19 | |
| Recurrence and Anal Fistula Patient Reported Outcomes Trial Perianal fistula surgical repair - Anal Fistula Surgery, Anal Fistula | Recruiting | National and Kapodistrian University of Athens | 100 | 2026-01-01 | 2026-03-19 | |
| Comparison Of Surgical Outcomes Between Ligation Of Intersphincteric Fistula Tract And Fistulotomy With Seton In Perianal Fistula Ligation of Intersphincteric Fistula Tract (LIFT), Fistulotomy with Seton Placement - Anal Fistula, Perianal Fistula | Not applicable | Completed | Islamabad Medical and Dental College | 100 | 2026-01-01 | 2026-06-03 |
| Determining the Effect of Education Given to Patients Undergoing Outpatient Anal Fistula Surgery Teach-back discharge education - Anal Fistula, Patient Discharge Education | Not applicable | Not yet recruiting | Muğla Sıtkı Koçman University | 76 | 2025-12-31 | 2026-01-07 |
| Study on the Mechanism of Zuoqing San Promoting Postoperative Wound Healing of Anal Fistula by Inhibiting ROS-dependent NETosis Solution of Zuoqing San for fumigation and washing of the postoperative wound of anal fistula, Equal-volume placebo inhalation rinse - Anal Fistula | Early Phase 1 | Enrolling by invitation | The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine | 60 | 2025-08-01 | 2025-08-19 |
| Study on Repeat Liposomal Bupivacaine for Post-Surgery Pain in Anal Fistula Patients. A single dose of liposomal bupivacaine is administered at the conclusion of surgery without adjunctive analgesics, followed by a supplemental dose 72 hours postoperatively. - Anal Fistula | Not applicable | Recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 408 | 2025-07-16 | 2025-07-23 |
| Machine Learning-Based Risk Stratification for Fistula Formation After Perianal Abscess Drainage Perianal Abscess, Anal Fistula | Not yet recruiting | Gumushane State Hospital | 450 | 2025-07-01 | 2025-06-13 | |
| Cross-cultural Adaptation of the Chinese Version of QoLAF-Q (Quality of Life in Patients With Anal Fistula Questionnaire) ：A Multi-center Study Anal fistula surgery - Anal Fistula | Not yet recruiting | Changhai Hospital | 150 | 2025-05-01 | 2025-05-08 | |
| Effect of Enhanced Recovery After Surgery for Benign Anorectal Conditions Enhanced recovery after surgery protocol, Routine pathway - Anal Fistula, Anal Fissure Chronic | Not applicable | Recruiting | Mansoura University | 100 | 2024-12-17 | 2025-02-03 |
| Evaluating an rhPDGF-BB-enhanced Collagen Plug for Perianal Fistula Healing RhPDGF-BB - Anal Fistula, Complex Perianal Fistula | Phase 2 | Completed | Aimal Khan | 13 | 2024-11-25 | 2026-11-12 |
| Tissue Therapy of Transsphincteric Anal Fistula ADRC injection, ADRC001 injection - Anal Fistula | Phase 1 / Phase 2 | Recruiting | University of Southern Denmark | 75 | 2024-10-09 | 2024-11-05 |
| Role of Autologous Platelet Rich Plasma(PRP) Injection and Platelet Rich Fibrin Glue(PRFG) Interposition for Treatment of Anal Fistula PRP and PRFG in treatment of anal fistula - Anal Fistula | Not applicable | Not yet recruiting | Assiut University | 60 | 2024-09-01 | 2023-10-23 |
| Evaluate the Distribution and Dynamic Behavior of TH-SC01 Cells in Vivo in Patients With Perianal Fistula Mesenchymal Stem Cells (MSCs) - Anal Fistula, Complex Perianal Fistulas | Phase 1 | Unknown | Jiangsu Topcel-KH Pharmaceutical Co., Ltd. | 8 | 2024-04-08 | 2024-06-12 |
| A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas RD2 Ver.02, Saline - Anal Fistula | Not applicable | Recruiting | RedDress Ltd. | 110 | 2024-01-20 | 2025-11-13 |
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Rectal Fistula (94) · Crohn Disease (10) · Fistula (6) · Hemorrhoids (6) · Fissure in Ano (4) · Pain, Postoperative (4) · Recurrence (3) · 3-Methylglutaconic Aciduria, Type V (1) · Abscess (1) · Achalasia Addisonianism Alacrimia syndrome (1) · Acrodysostosis (1) · Activated PI3K-delta Syndrome (1) · Addison Disease (1) · Alagille Syndrome (1) · Alstrom Syndrome (1)
Digestive System Diseases (94) · Digestive System Fistula (94) · Gastrointestinal Diseases (94) · Intestinal Diseases (94) · Intestinal Fistula (94) · Pathological Conditions, Anatomical (94) · Pathological Conditions, Signs and Symptoms (94) · Rectal Diseases (94) · Fistula (88) · Gastroenteritis (11) · Inflammatory Bowel Diseases (10) · Pathologic Processes (9) · Cardiovascular Diseases (7) · Vascular Diseases (7) · Neurologic Manifestations (5)
Metronidazole (3) · Surgical Procedures, Operative (3) · Amoxicillin-Potassium Clavulanate Combination (2) · Ciprofloxacin (2) · Fibrin Tissue Adhesive (2) · Lipectomy (2) · Anti-Bacterial Agents (1) · Becaplermin (1) · Control Groups (1) · Decompression (1) · Diosmin (1) · Electroacupuncture (1) · Fumigation (1) · Gelatin Sponge, Absorbable (1) · Hesperidin (1)
Mansoura University (10) · Assiut University (4) · Cook Group Incorporated (4) · Region Skane (4) · Ankara University (3) · University of Southern Denmark (3) · Sixth Affiliated Hospital, Sun Yat-sen University (2) · State Scientific Centre of Coloproctology, Russian Federation (2) · Taipei Medical University Shuang Ho Hospital (2) · The Cleveland Clinic (2) · Tigenix S.A.U. (2) · Zhen Jun Wang (2) · Acibadem Kent Hospital (1) · Aimal Khan (1) · Al-Azhar University (1)
Egypt (13) · United States (13) · China (8) · Spain (8) · France (6) · Turkey (Türkiye) (6) · Sweden (5) · Russia (4) · Denmark (3) · Germany (2) · Italy (2) · Pakistan (2) · Taiwan (2) · Austria (1) · Belgium (1)
Laurent Abramowitz, MD (2) · Sameh Emile, M.D. (2) · Sameh H Emile, M.D. (2) · Adriana M Cadavid, MD (1) · Ahmad Zubaidi, MD (1) · Alexander T Hawkins (1) · Amy Lightner, MD (1) · Andreas M Kaiser, MD (1) · Antonio Nocito, MD (1) · Bao Ming Zhao, M.D. (1) · Beth Moore, MD (1) · Chang Shun Wang, M.D. (1) · Chao Wen Chen, M.D. (1) · Christopher Dawoud, MD (1)
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