221 completed, 64 unknown, 40 terminated, 38 recruiting. 103 Not applicable, 92 Phase 2, 60 Phase 1, 39 Phase 3, 25 Phase 4.
Follow Age-Related Macular Degeneration: new trials by email Literature Review of Age-Related Macular Degeneration trials Research Report on Age-Related Macular Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Non-invasive Ultrasound Retinal Stimulation for Vision Restoration Non-invasive ultrasound retinal stimulation Device - Age-Related Macular Degeneration, Retinitis Pigmentosa | Not applicable | Not yet recruiting | University of Southern California | 5 | 2027-01-10 | 2026-01-08 |
| Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study Repeated intravitreal anti-VEGF injection with eyelid speculum - Blepharoptosis, Age-Related Macular Degeneration | Recruiting | Abdulkadir Küçük | 60 | 2026-09-25 | 2026-10-22 | |
| A First-In-Human Study of ARO-033 in Adult Participants ARO-033, Placebo - Age-related Macular Degeneration | Phase 1 | Recruiting | Arrowhead Pharmaceuticals | 84 | 2026-06-25 | 2026-09-15 |
| Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension Low glycemic Mediterranean diet behavioral modification - Age-Related Macular Degeneration | Not applicable | Not yet recruiting | Stanford University | 32 | 2026-06-01 | 2026-05-26 |
| A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) Tiespectus, Aflibercept - Macular Degeneration, Age-Related Macular Degeneration | Phase 2 / Phase 3 | Recruiting | EyeBiotech Ltd. | 960 | 2026-04-15 | 2026-08-06 |
| User-centric Study of Patients' Receptiveness Towards the Web-based Automated Vision Impairment Gaze-tracking Analysis Systems Age-Related Macular Degeneration, Wet Age-related Macular Degeneration | Enrolling by invitation | Tan Tock Seng Hospital | 30 | 2026-04-01 | 2026-10-02 | |
| A Study to Evaluate the Usability of the SB11 PFS in Trial Participants With Wet AMD, Macular Oedema Secondary to RVO, or mCNV SB11 PFS - Age-Related Macular Degeneration, Branch Retinal Vein Occlusion With Macular Edema | Phase 2 | Completed | Samsung Bioepis Co., Ltd. | 30 | 2026-03-30 | 2026-04-24 |
| A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) Tiespectus, Aflibercept - Macular Degeneration, Age-Related Macular Degeneration | Phase 2 / Phase 3 | Recruiting | EyeBiotech Ltd. | 960 | 2026-03-27 | 2026-10-02 |
| Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression Krill Oil, Olive Oil - Age-Related Macular Degeneration | Not applicable | Recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 24 | 2025-10-17 | 2026-01-02 |
| AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance Streetlab VR - Age-Related Macular Degeneration | Not applicable | Recruiting | Duke University | 100 | 2025-08-15 | 2026-08-10 |
| Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration ABBV-6628, SYFOVRE - Geographic Atrophy, Age-Related Macular Degeneration | Phase 1 / Phase 2 | Recruiting | AbbVie | 66 | 2025-08-13 | 2026-07-13 |
| Preparation of Patient Autologous Induced Pluripotent Stem Cell-derived Retinal Cells for AMD somatic cell collection - Age-Related Macular Degeneration | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 10 | 2025-08-01 | 2025-01-28 | |
| A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) RO7669330, Syfovre™, Izervay™ - Geographic Atrophy, Age-related Macular Degeneration | Phase 1 | Terminated | Hoffmann-La Roche | 27 | 2025-07-16 | 2026-08-10 |
| A Study About the Safety of ASP3021 Eye Injections and if They Help People in Japan With Vision Loss From Age-related Macular Degeneration avacincaptad pegol - Geographic Atrophy, Age-Related Macular Degeneration | Phase 4 | Active not recruiting | Astellas Pharma Inc | 17 | 2025-07-08 | 2026-09-30 |
| Safety of BBC1501 Intravitreal Injection in Patients With Neovascular Age-Related Macular Degeneration (nAMD) BBC1501 - Age-Related Macular Degeneration | Phase 1 | Recruiting | Benobio Co., Ltd. | 18 | 2025-07-01 | 2026-05-15 |
| Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study Optical coherence tomography, Microperimetry - Age-Related Macular Degeneration, Geographic Atrophy | Recruiting | University of California, San Francisco | 80 | 2025-06-11 | 2026-04-29 | |
| The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration Oral disulfiram - Alcohol Use Disorder, Retinal Dystrophies | Phase 1 | Recruiting | University of Rochester | 15 | 2025-05-19 | 2026-09-16 |
| Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID) Retinal Imaging - Age-Related Macular Degeneration | Recruiting | University of Wisconsin, Madison | 1000 | 2025-05-12 | 2026-03-27 | |
| Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration i-Lumen AMD - Age-Related Macular Degeneration, Age-related Macular Degeneration (ARMD) | Not applicable | Recruiting | i-Lumen Scientific AUS PTY LTD | 100 | 2025-05-07 | 2026-08-26 |
| The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma occupational therapy interventions for low vision care - Age-Related Macular Degeneration | Early Phase 1 | Recruiting | MCPHS University | 50 | 2025-04-22 | 2026-05-12 |
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Macular Degeneration (400) · Geographic Atrophy (52) · Choroidal Neovascularization (45) · Diabetic Retinopathy (28) · Wet Macular Degeneration (18) · Eye Diseases (17) · Retinal Vein Occlusion (17) · Glaucoma (15) · Retinal Diseases (13) · Vision Disorders (10) · Macular Edema (8) · Retinitis Pigmentosa (8) · Cataract (7) · Retinal Degeneration (6) · Vision, Low (6)
Retinal Degeneration (394) · Retinal Diseases (387) · Eye Diseases (383) · Pathological Conditions, Signs and Symptoms (73) · Pathologic Processes (56) · Uveal Diseases (52) · Choroid Diseases (50) · Metaplasia (50) · Neovascularization, Pathologic (49) · Vascular Diseases (44) · Cardiovascular Diseases (43) · Endocrine System Diseases (32) · Nervous System Diseases (31) · Diabetes Complications (29) · Diabetes Mellitus (29)
Ranibizumab (51) · aflibercept (18) · Bevacizumab (17) · salicylhydroxamic acid (8) · Lutein (6) · Photochemotherapy (6) · Sirolimus (6) · Verteporfin (6) · Zeaxanthins (6) · brolucizumab (6) · pegaptanib (6) · Tomography, Optical Coherence (5) · Blood Specimen Collection (4) · E10030 aptamer (4) · Triamcinolone Acetonide (4)
National Eye Institute (NEI) (21) · Novartis Pharmaceuticals (12) · Medical University of Vienna (10) · Ophthotech Corporation (8) · Santen Inc. (6) · Association for Innovation and Biomedical Research on Light and Image (5) · Outlook Therapeutics, Inc. (5) · Universitaire Ziekenhuizen KU Leuven (5) · University of California, San Francisco (5) · Alcon Research (4) · Center for Eye Research Australia (4) · Chengdu Origen Biotechnology Co., Ltd. (4) · Duke University (4) · Oraya Therapeutics, Inc. (4) · The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery (4)
United States (192) · Austria (28) · France (24) · Germany (24) · United Kingdom (24) · Australia (19) · Canada (19) · Italy (18) · China (16) · Spain (15) · Switzerland (15) · Israel (14) · South Korea (14) · Belgium (12) · Portugal (10)
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