6 completed, 5 recruiting, 4 terminated, 1 enrolling by invitation. 11 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 4, Recruiting 3, Terminated 3, Unknown 1 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment Nicotinamide Riboside, Placebo, Vitrectomy and Gas tamponade - Retinal Detachment | Phase 4 | Recruiting | Center for Eye Research Australia | 144 | 2025-09-19 | 2026-03-23 |
| Functional Assessments in Vision Impairment Retinitis Pigmentosa (RP), Diabetic Retinopathy (DR) | Not yet recruiting | Center for Eye Research Australia | 45 | 2025-04-01 | 2025-04-03 | |
| Defining Retinal Structures Using Hyperspectral Retinal Imaging Hyperspectral camera - Age-Related Macular Degeneration, Diabetic Retinopathy | Not applicable | Recruiting | Center for Eye Research Australia | 1000 | 2025-01-01 | 2026-04-29 |
| Subthreshold Nanosecond Laser for Non-resolving Central Serous Chorioretinopathy 2RT subthreshold nanosecond laser - active, 2RT subthreshold nanosecond laser - sham - Central Serous Chorioretinopathy | Not applicable | Unknown | Nova Eye Medical Pty Ltd. | 60 | 2022-10-18 | 2024-06-24 |
| The Glaucoma Nicotinamide Trial Nicotinamide, Placebo - Glaucoma | Not applicable | Recruiting | Umeå University | 660 | 2022-05-18 | 2023-07-27 |
| Subthreshold Laser Treatment in Intermediate Age-related Macular Degeneration With Nascent Geographic Atrophy Study 2RT subthreshold nanosecond laser - Age-Related Macular Degeneration | Not applicable | Terminated | Center for Eye Research Australia | 15 | 2021-12-13 | 2025-04-15 |
| Longitudinal Study of a Bionic Eye Retinitis Pigmentosa, Choroideremia | Enrolling by invitation | Center for Eye Research Australia | 7 | 2021-12-09 | 2024-08-23 | |
| Retinal Hyperspectral Imaging in Neurodegenerative Diseases Hyperspectral camera - Dementia, Neurodegenerative Diseases | Not applicable | Recruiting | Center for Eye Research Australia | 930 | 2021-10-11 | 2026-04-22 |
| Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression N/A Observational study - Age Related Macular Degeneration, Geographic Atrophy | Recruiting | Center for Eye Research Australia | 2500 | 2021-02-02 | 2024-02-09 | |
| Study of a Suprachoroidal Retinal Prosthesis 44Ch Bionic Eye Device - Retinitis Pigmentosa, Choroideremia | Not applicable | Completed | Mobius Medical Pty Ltd. | 4 | 2018-02-13 | 2021-08-16 |
| A Comparison of Cataract Surgery Alone and Cataract Surgery With iStent iStent inject®, Phacoemulsification and intraocular lens implant - Glaucoma, Open-Angle | Not applicable | Completed | Royal Victoria Eye and Ear Hospital | 93 | 2018-02-01 | 2023-08-09 |
| Enhancing the Lucentis (Ranibizumab) Management of Choroidal Neovascular Membranes With Hyperspectral Imaging Hyperspectral imaging - Macular Degeneration, Choroidal Neovascularization | Terminated | Center for Eye Research Australia | 4 | 2017-11-14 | 2019-02-05 | |
| Laser Therapy Combined With Intravitreal Aflibercept vs Intravitreal Aflibercept Monotherapy (LADAMO) Aflibercept, Targeted laser therapy - Diabetic Retinopathy | Phase 4 | Completed | University of Sydney | 48 | 2017-06-15 | 2022-05-31 |
| Defining Retinal and Choroidal Structures Using Hyperspectral Imaging Hyperspectral retinal imaging - Retinal Disease | Not applicable | Terminated | Center for Eye Research Australia | 679 | 2016-02-25 | 2026-04-15 |
| Detecting Beta-amyloid in the Retina Hyperspectral camera - Dementia, Alzheimer Disease | Not applicable | Terminated | Center for Eye Research Australia | 186 | 2016-02-04 | 2026-04-24 |
| Pilot Study of a Suprachoroidal Retinal Prosthesis Prototype wide view suprachoroidal retinal prosthesis - Retinitis Pigmentosa, Choroideremia | Not applicable | Completed | Center for Eye Research Australia | 3 | 2012-05-01 | 2016-11-16 |
| Laser Intervention in Early Age-Related Macular Degeneration Study 2RT nanosecond laser - Age-related Macular Degeneration | Not applicable | Completed | Center for Eye Research Australia | 292 | 2011-11-01 | 2025-04-15 |
| Incidence of Retinopathy and Associated Risk Factors in Children and Young Adults With Type 1 Diabetes in Denmark Type 1 Diabetes, Diabetic Retinopathy | Completed | Odense University Hospital | 132 | 2011-01-01 | 2014-07-30 |
Macular Degeneration (6) · Diabetic Retinopathy (4) · Retinitis Pigmentosa (4) · Choroideremia (3) · Glaucoma (3) · Retinal Diseases (3) · Alzheimer Disease (2) · Dementia (2) · Central Serous Chorioretinopathy (1) · Choroidal Neovascularization (1) · Dementia, Vascular (1) · Diabetes Mellitus, Type 1 (1) · Frontotemporal Dementia (1) · Geographic Atrophy (1) · Glaucoma, Open-Angle (1)
Hyperspectral Imaging (1) · Lasers (1) · Lens Implantation, Intraocular (1) · Niacinamide (1) · Phacoemulsification (1) · Vitrectomy (1) · aflibercept (1) · nicotinamide-beta-riboside (1)
Australia (15) · Denmark (1) · Sweden (1)
Penelope J Allen, FRACO, FRACS (2) · Anthony Burkitt, PhD (1) · Brian Ang, FRANZCO (1) · David Sousa, MD PhD FRANZCO (1) · Jennifer Fan Gaskin, FRANZCO (1) · Mali Okada, MBBS FRANZCO (1) · Marc G Sarossy, FRANZCO (1) · Penelope Allen, FRACO, FRACS (1) · Robyn Guymer, MBBS, PhD (1) · Robyn H Guymer, MBBS FRANZCO (1) · Robyn H Guymer, PhD, FRANZCO (1) · Samantha Fraser-Bell, PhD FRANZCO (1)
PMID 25205858, PMID 25521292, PMID 27170910, PMID 28660276, PMID 28793152, PMID 33009222, PMID 34383875, PMID 34581770, PMID 35696133, PMID 36066322, PMID 37831941, PMID 39028907, PMID 40174607