208 completed, 55 unknown, 28 terminated, 19 recruiting. 81 Phase 2, 60 Not applicable, 59 Phase 3, 49 Phase 1, 38 Phase 4.
Follow Choroid Diseases: new trials by email Literature Review of Choroid Diseases trials Research Report on Choroid Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial aflibercept 8 mg - Polypoidal Choroidal Vasculopathy, Polypoidal Choroidal Vasculopathy (PCV) | Phase 3 | Recruiting | Yeungnam University College of Medicine | 50 | 2026-12-24 | 2026-02-05 |
| Morpho-functional Evaluation of the Retina and Choroid Using Multimodal Imaging in Healthy Subjects and Patients With Retino-choroidal Diseases Retinal Diseases, Choroidal Diseases | Not yet recruiting | Fondazione G.B. Bietti, IRCCS | 125 | 2026-10-01 | 2026-09-04 | |
| Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and Safety Eyelid Speculum Retraction, Cotton-Tipped Applicator Retraction - Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema | Not applicable | Active not recruiting | Jakkrit Juhong | 129 | 2026-09-09 | 2026-09-25 |
| A Study to Evaluate the Efficacy and Safety of VIS-101 in Participants With Neovascular Age-Related Macular Degeneration VIS-101 6.0mg Low concentration, VIS-101 6.0mg High concentration, VIS-101 9.0mg High concentration - Neovascular Age Related Macular Degeneration(nAMD) | Phase 2 | Not yet recruiting | Everest Medicines (China) Co.,Ltd. | 244 | 2026-09-01 | 2026-09-10 |
| A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) Tiespectus, Aflibercept - Macular Degeneration, Age-Related Macular Degeneration | Phase 2 / Phase 3 | Recruiting | EyeBiotech Ltd. | 960 | 2026-04-15 | 2026-08-06 |
| Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program CDSMP + caregiver support, Usual Care - Choroid Disease, Caregiver | Not applicable | Recruiting | The Hong Kong Polytechnic University | 309 | 2026-04-01 | 2026-09-17 |
| A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) Tiespectus, Aflibercept - Macular Degeneration, Age-Related Macular Degeneration | Phase 2 / Phase 3 | Recruiting | EyeBiotech Ltd. | 960 | 2026-03-27 | 2026-10-02 |
| Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal Vasculopathy Faricimab Injection [Vabysmo] - Polypoidal Choroidal Vasculopathy (PCV), Age Related Macular Degeneration | Phase 3 | Recruiting | Yeungnam University College of Medicine | 50 | 2026-03-01 | 2026-03-10 |
| A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV) Aflibercept Intravitreous Injection - Polypoidal Choroidal Vasculopathy (PCV), Neovascular Age Related Macular Degeneration (AMD) | Phase 4 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 174 | 2026-01-01 | 2026-01-26 |
| Establishment of a Multimodal Standard Database for Inflammation-related Ophthalmopathy Ocular Surface Disease, Inflammatory Disease | Recruiting | Dan Chen | 3000 | 2025-11-26 | 2026-06-05 | |
| Long Term Efficacy of Faricimab Using a Treat and Extend Regimen for Type 3 Macular Neovascularization Intravitreal faricimab injection - Age-related Macular Degeneration (ARMD), Choroidal Neovascularization | Phase 4 | Not yet recruiting | Kim's Eye Hospital | 30 | 2025-09-23 | 2025-09-23 |
| Faricimab Quarterly Maintenance for Neovascular Age Related Macular Degeneration Faricimab Injection [Vabysmo] - Macular Degeneration Choroidal Neovascularization | Phase 4 | Recruiting | Hospital Authority, Hong Kong | 40 | 2025-08-21 | 2025-10-01 |
| Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO) Faricimab Injection [Vabysmo] - Polypoidal Choroidal Vasculopathy | Phase 4 | Recruiting | Association for Innovation and Biomedical Research on Light and Image | 120 | 2025-08-06 | 2026-02-06 |
| AVIGA3 (Cohort 2.0) Amsler Grid, AVIGA - Maculopathy | Not applicable | Recruiting | Tan Tock Seng Hospital | 60 | 2025-06-16 | 2026-06-24 |
| The Treatment Burden of Myopic Choroidal Neovascularization anti-VEGF intravitreal treatment in patients affected by myopic choroidal neovascularization - Myopic Choroidal Neovascularisation, Anti-VEGF Treatment | Not yet recruiting | Policlinico Gaspare Rodolico - San Marco Catania | 100 | 2025-06-01 | 2025-06-06 | |
| Effect of Video Viewing on Intravitreal Injection Experience Procedure video viewing - Age Related Macular Degeneration, Diabetic Retinopathy | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 182 | 2025-05-05 | 2025-06-03 |
| An Interpretable Fundus Diseases Report Generating System Based On Weakly Labelings With fundus diseases, Without fundus diseases - Retinal Diseases, Choroidal Disease | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 9999 | 2025-05-01 | 2025-04-09 | |
| Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) Shunt Suprachoroidal silicone tube (SST) shunt - Glaucoma, Open Angle Glaucoma (OAG) | Recruiting | Davinci LTD | 66 | 2024-11-08 | 2024-11-15 | |
| Switching to Aflibercept 8mg in Patients Showing Limited Response to Previous Treatment Aflibercept 8mg - Age-related Macular Degeneration (ARMD) | Phase 4 | Completed | Kim's Eye Hospital | 35 | 2024-10-21 | 2026-07-16 |
| Quantification & Classification of Inflammatory Cells in Uveitis Using OCT Anterior Uveitis (AU), Birdshot Chorioretinitis | Recruiting | Oregon Health and Science University | 125 | 2024-09-01 | 2025-07-17 |
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Choroidal Neovascularization (203) · Macular Degeneration (142) · Polypoidal Choroidal Vasculopathy (50) · Choroideremia (34) · Retinal Diseases (22) · Gyrate Atrophy (17) · Macular Edema (17) · Wet Macular Degeneration (17) · Retinitis Pigmentosa (14) · Uveitis (14) · Diabetic Retinopathy (13) · Eye Diseases (13) · Retinal Degeneration (13) · Retinal Vein Occlusion (13)
Uveal Diseases (346) · Eye Diseases (333) · Pathological Conditions, Signs and Symptoms (259) · Pathologic Processes (254) · Metaplasia (246) · Neovascularization, Pathologic (241) · Retinal Diseases (191) · Retinal Degeneration (160) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (62) · Genetic Diseases, Inborn (60) · Eye Diseases, Hereditary (59) · Choroidal Neovascularization (42) · Cardiovascular Diseases (40) · Vascular Diseases (37)
Ranibizumab (69) · aflibercept (32) · Bevacizumab (20) · Verteporfin (20) · Triamcinolone Acetonide (10) · brolucizumab (9) · salicylhydroxamic acid (8) · Intravitreal Injections (7) · Dexamethasone (5) · Photochemotherapy (5) · faricimab (5) · KH902 fusion protein (4) · Tomography, Optical Coherence (4) · pazopanib (4) · E10030 aptamer (3)
Novartis Pharmaceuticals (23) · National Eye Institute (NEI) (16) · Novartis (8) · Notal Vision Ltd. (7) · Johns Hopkins University (6) · Medical University of Vienna (6) · Ophthotech Corporation (6) · Asociación para Evitar la Ceguera en México (5) · GlaxoSmithKline (5) · Singapore National Eye Centre (5) · Alcon Research (4) · Allergan (4) · Bayer (4) · Benha University (4) · Biogen (4)
United States (132) · France (36) · Italy (29) · Germany (27) · United Kingdom (27) · South Korea (26) · China (25) · Canada (23) · Spain (21) · Australia (18) · Switzerland (16) · Israel (14) · Portugal (14) · Austria (13) · Brazil (12)
Andrii MD Korol, PhD (3) · Gabriela Burian, MD (3) · Chong-Lye Ang, FRCOphth (2) · Christian Pruente, MD (2) · Dennis M. Marcus, M.D. (2) · Gregg T Kokame, MD, MMM (2) · Ian M MacDonald, MD, CM (2)
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