15 completed, 1 not yet recruiting, 1 recruiting, 1 terminated. 9 Phase 4, 6 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Completed 7, Recruiting 1, Terminated 1 |
| Not applicable | 6 | Completed 5, Not yet recruiting 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Acute Asthma: new trials by email Literature Review of Acute Asthma trials Research Report on Acute Asthma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bilevel Positive Airway Pressure (BPAP) for Severe Asthma Bilevel positive airway pressure ventilation - Pediatric Asthma, Acute Asthma | Not applicable | Not yet recruiting | Columbia University | 36 | 2026-12-01 | 2026-11-03 |
| Dosing of Steroids for Acute Asthma Given in the Emergency Department - a Pilot Randomised Feasibility Trial of Dexamethasone in Children dexamethasone oral - Acute Asthma, Dexamethasone | Phase 4 | Recruiting | Sheffield Children's NHS Foundation Trust | 104 | 2026-02-23 | 2026-04-23 |
| Supporting Parents to Choose Wisely Blogshots 1-3, Blogshots 4-6 - Common Cold, Pharyngitis | Not applicable | Completed | University of Alberta | 174 | 2023-06-05 | 2025-05-22 |
| Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Budesonide, normal saline - Acute Asthma | Phase 1 | Unknown | University of Monastir | 60 | 2019-05-20 | 2019-07-11 |
| Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial Inhaled corticosteroid, Placebo - Bacterial Pneumonia, Viral Pneumonia | Phase 3 | Completed | Makerere University | 1010 | 2012-12-01 | 2015-10-27 |
| Feasibility of an ED Initiated Online Asthma Management Program for Urban Teens Tailored asthma management program, Generic web-based education - Acute Asthma | Not applicable | Completed | Henry Ford Health System | 126 | 2012-10-01 | 2015-04-01 |
| Emergency Department (ED)-Directed Interventions to Improve Asthma Outcomes Opinion Leader letter, Involvement of a care manager, Usual care - Acute Asthma | Not applicable | Completed | University of Alberta | 367 | 2012-06-01 | 2016-11-21 |
| Magnesium Nebulization Utilization in Management of Pediatric Asthma Magnesium Sulfate Sandoz, Sodium Chloride , USP PPC - Acute Asthma | Phase 2 | Completed | The Hospital for Sick Children | 818 | 2011-09-26 | 2020-04-02 |
| Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children Montelukast 4 Mg Oral Granule, Placebos - Acute Asthma, Acute Wheezy Bronchitis | Phase 4 | Completed | Kecioren Education and Training Hospital | 100 | 2011-08-01 | 2017-12-11 |
| Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children Prednisolone Sodium Phosphate, Dexamethasone - Asthma, Acute Asthma | Phase 4 | Completed | University College Dublin | 250 | 2011-07-06 | 2018-10-09 |
| Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study Albuterol - Acute Asthma | Not applicable | Completed | Vanderbilt University Medical Center | 16 | 2010-09-01 | 2017-09-29 |
| Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children. montelukast 4 mg granule, Montelukast placebo granüle - Asthma, Acute Asthma | Phase 4 | Completed | Kecioren Education and Training Hospital | 80 | 2010-04-01 | 2011-12-20 |
| Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms Acute Asthma | Completed | MetroHealth Medical Center | 311 | 2009-12-01 | 2021-09-01 | |
| Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation Continuous positive airway pressure - Acute Asthma | Phase 4 | Completed | Ramathibodi Hospital | 86 | 2009-04-01 | 2011-07-27 |
| A Pilot Study to Determine the Most Effective Dose of Arformoterol for Treating Acute Asthmatic Patients arformoterol (RR formoterol), placebo, levalbuterol - Acute Asthma | Phase 4 | Terminated | Henry Ford Health System | 2 | 2009-01-01 | 2023-05-24 |
| Heliox and Posture in Patients With Asthma HELIOX, OXYGEN, HELIOX+POSTURE - Acute Asthma | Not applicable | Completed | Universidade Federal de Pernambuco | 59 | 2008-06-01 | 2009-06-17 |
| Budesonide for Emergency Treatment of Acute Wheezing in Children 0.5 mg/ml budesonide nebules, Saline - Asthma, Acute Asthma | Phase 4 | Completed | Kecioren Education and Training Hospital | 100 | 2007-09-01 | 2011-12-20 |
| Nebulized Budesonide for Children Who Are Hospitalized for Acute Wheezing Budesonide 0.5 mg/ml nebules, % 0.9 Saline solution - Asthma, Acute Asthma | Phase 4 | Completed | Kecioren Education and Training Hospital | 100 | 2007-09-01 | 2011-12-20 |
| Budesonide Inhalation Suspension for Acute Asthma in Children Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide - Asthma, Acute Asthma | Phase 4 | Completed | Children's Hospital of Philadelphia | 179 | 2006-12-01 | 2012-08-10 |
Asthma (11) · Emergencies (6) · Respiratory Sounds (2) · Bronchial Diseases (1) · Bronchiolitis (1) · Common Cold (1) · Otitis Media (1) · Pharyngitis (1) · Pneumonia, Bacterial (1) · Pneumonia, Viral (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Recurrence (1)
Lung Diseases (13) · Respiratory Tract Diseases (13) · Immune System Diseases (12) · Lung Diseases, Obstructive (12) · Bronchial Diseases (11) · Hypersensitivity (11) · Hypersensitivity, Immediate (11) · Respiratory Hypersensitivity (11) · Pathological Conditions, Signs and Symptoms (7) · Disease Attributes (6) · Pathologic Processes (6) · Infections (2) · Respiratory Tract Infections (2) · Signs and Symptoms (2) · Signs and Symptoms, Respiratory (2)
Budesonide (4) · Saline Solution (3) · Albuterol (2) · Dexamethasone (2) · Methylprednisolone (2) · Prednisolone (2) · Sodium Chloride (2) · montelukast (2) · Continuous Positive Airway Pressure (1) · Formoterol Fumarate (1) · Ipratropium (1) · Levalbuterol (1) · MUSK protein, human (1) · Magnesium Sulfate (1) · NPSR1 protein, human (1)
Kecioren Education and Training Hospital (4) · Henry Ford Health System (2) · University of Alberta (2) · Children's Hospital of Philadelphia (1) · Columbia University (1) · Makerere University (1) · MetroHealth Medical Center (1) · Ramathibodi Hospital (1) · Sheffield Children's NHS Foundation Trust (1) · The Hospital for Sick Children (1) · Universidade Federal de Pernambuco (1) · University College Dublin (1) · University of Monastir (1) · Vanderbilt University Medical Center (1)
United States (5) · Turkey (Türkiye) (4) · Canada (3) · Brazil (1) · Ireland (1) · Thailand (1) · Tunisia (1) · Uganda (1) · United Kingdom (1)
C H Razi, MD (2) · Armele Andrade (1) · Bjug Borgundvaag, MD (1) · Brian H Rowe, MD, MSc (1) · Bryan D. Upham, M.D. (1) · Cem H. Razi, M.D. (1) · Christine LM Joseph, PhD, MPH (1) · Christopher McCabe, PhD (1) · Cristina Villa-Roel, MD, MSc (1) · Cynthia J Mollen, M.D. (1) · Donald H Arnold, MD, MPH (1) · Eddy Lang, MD (1) · Grace Ndeezi, PhD (1)
PMID 10453854, PMID 10471601, PMID 15764724, PMID 16723037, PMID 21352660, PMID 27220675, PMID 28649417, PMID 33231663, PMID 34279646, PMID 35870902, PMID 42173560, PMID 9925082
K23HL080005 (1), R34HL173384 (1)