59 completed, 30 unknown, 14 recruiting, 5 terminated. 40 Not applicable, 19 Phase 2, 9 Phase 1, 7 Phase 3, 4 Phase 4.
Follow Eye Abnormalities: new trials by email Literature Review of Eye Abnormalities trials Research Report on Eye Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Long-Term Safety of Ultevursen in Participants With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene No intervention, will not receive any active study intervention, Intravitreal Injection of Ultevursen - Retinitis Pigmentosa (RP), Usher Syndrome Type 2 | Phase 2 | Not yet recruiting | Laboratoires Thea | 81 | 2026-10-05 | 2026-09-01 |
| Efficacy of Visual and Perceptual Training on Visual Function for Operative Congenital Ectopia Lentis Children perceptual learning visual treatment,HVT - Ectopia Lentis, Lens Subluxation or Dislocation | Not applicable | Recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 82 | 2026-06-01 | 2026-04-27 |
| Goniotomy in Primary Congenital Glaucoma Primary Congenital Glaucoma, Goniotomy | Not yet recruiting | Sun Yat-sen University | 120 | 2026-05-01 | 2026-04-24 | |
| Study Aim to Compare the Effect of Different Technique of Airway Managment During Anaesthesia on the Haemodynamics and Intraocular Pressure. Patients Were Divided Into Three Groups of 25 Patients Each. (Group A); Patients Who Were Subjected to LMA Insertion (Group B ). laryngeal mask insertion, I gel mask insertion, Endotracheal tube insertion - Congenital Glaucoma | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-03-10 | 2026-03-31 |
| Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION) sepofarsen, Placebo IVT - Leber Congenital Amaurosis 10, Blindness | Phase 3 | Recruiting | Laboratoires Thea | 32 | 2025-06-04 | 2026-10-21 |
| Physical Activity and Community EmPOWERment Project PACE Program - Intellectual Disability, Neurodevelopmental Disorders | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 376 | 2025-01-10 | 2026-02-23 |
| Agreement and Precision Study Pachymeter - Eye Abnormalities, Normal Eyes | Completed | Topcon Corporation | 108 | 2025-01-09 | 2025-02-04 | |
| Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene Intravitreal Injection of Ultevursen, No intervention, will not receive any active study intervention - Retinitis Pigmentosa (RP), Usher Syndrome Type 2 | Phase 2 | Active not recruiting | Laboratoires Thea | 81 | 2024-12-11 | 2026-07-09 |
| Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) Shunt Suprachoroidal silicone tube (SST) shunt - Glaucoma, Open Angle Glaucoma (OAG) | Recruiting | Davinci LTD | 66 | 2024-11-08 | 2024-11-15 | |
| Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations Blood sampling - Eye Abnormalities | Recruiting | University Hospital, Toulouse | 20 | 2024-11-05 | 2026-03-18 | |
| National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases Inherited Ophthalmic Diseases, Hypopigmentation Disorder | Recruiting | National Eye Institute (NEI) | 1000 | 2024-07-12 | 2026-06-09 | |
| Electron Microscopic Examination of Iris Tissue in Buphthalmos Combined trabeculotomy trabeculectomy with mitomycin C - Iris Diseases | Not applicable | Completed | Assiut University | 20 | 2024-06-01 | 2025-06-24 |
| Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies Rare Diseases, Aniridia | Unknown | IRCCS Ospedale San Raffaele | 274 | 2024-05-01 | 2024-05-14 | |
| Safety and Efficacy of 18 mm Short Vitrectomy Probe for Pediatric Vitreoretinal Surgeries Pars plana vitrectomy with a 18 mm short vitrector - Retinopathy of Prematurity Both Eyes, Retinal Disease | Phase 4 | Recruiting | Chang Gung Memorial Hospital | 60 | 2024-03-05 | 2024-07-25 |
| Assessing Combined Bevacizumab-Mitomycin C Use During Ahmed Valve Revision in Recurrent Pediatric Glaucoma AGV plate, bevacizumab injection - Pediatric Glaucoma | Early Phase 1 | Completed | Benha University | 50 | 2024-02-09 | 2025-05-21 |
| Combined Nasal Goniotomy-Temporal Trabeculotomy Versus Temporal Trabeculotomy for Management of Primary Congenital Glaucoma combined Nasal goniotomy-Temporal trabeculotomy, Temporal trabeculotomy - Primary Congenital Glaucoma | Not applicable | Completed | Zagazig University | 21 | 2024-02-01 | 2026-09-21 |
| Incidence and Risk Factors of Ocular Complications Among Patients With Homocystinuria Lensectomy and vitrectomy - Complications | Unknown | King Fahad Armed Forces Hospital | 6 | 2024-01-01 | 2024-08-13 | |
| Treatment of LSCD With DM transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD - Limbal Stem-cell Deficiency, Congenital Aniridia | Phase 1 | Completed | University of Minnesota | 19 | 2023-11-30 | 2026-01-08 |
| Safety and Efficacy of Suprachoroidal Tube Shunt in Patients With Primary Open and Pseudoexfoliation Glaucomas Glaucoma, Open-Angle, Suprachoroidal Space | Unknown | Davinci LTD | 91 | 2023-11-20 | 2023-12-04 | |
| Potential Environmental Causes of Uveal Coloboma Coloboma | Completed | National Eye Institute (NEI) | 87 | 2023-06-20 | 2026-09-17 |
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Hydrophthalmos (37) · Aniridia (22) · Glaucoma (14) · Vision Disorders (14) · Eye Diseases (12) · Retinal Diseases (12) · Choroidal Effusions (11) · Anophthalmos (10) · Eye Diseases, Hereditary (10) · Microphthalmos (8) · Coloboma (7) · Ectopia Lentis (7) · Leber Congenital Amaurosis (7) · Glaucoma, Open-Angle (6)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (110) · Eye Diseases (109) · Congenital Abnormalities (105) · Genetic Diseases, Inborn (39) · Ocular Hypertension (39) · Uveal Diseases (38) · Infant, Newborn, Diseases (37) · Glaucoma, Open-Angle (36) · Eye Diseases, Hereditary (34) · Glaucoma (30) · Nervous System Diseases (28) · Iris Diseases (27) · Pathological Conditions, Signs and Symptoms (27) · Signs and Symptoms (22)
Trabeculectomy (4) · Intravitreal Injections (3) · Mitomycin (3) · Blood Specimen Collection (2) · Surveys and Questionnaires (2) · Tomography, Optical Coherence (2) · Triamcinolone Acetonide (2) · ataluren (2) · Adrenal Cortex Hormones (1) · Bevacizumab (1) · Cataract Extraction (1) · Drug Delivery Systems (1) · Eye-Tracking Technology (1) · Functional Status (1) · Intubation, Intratracheal (1)
National Eye Institute (NEI) (9) · Laboratoires Thea (6) · Mansoura University (5) · Clearside Biomedical, Inc. (3) · ProQR Therapeutics (3) · Zhongshan Ophthalmic Center, Sun Yat-sen University (3) · Alcon Research (2) · Assiut University (2) · Benha University (2) · Davinci LTD (2) · Editas Medicine, Inc. (2) · Heidelberg Engineering GmbH (2) · National Human Genome Research Institute (NHGRI) (2) · PTC Therapeutics (2) · Sohag University (2)
United States (45) · Egypt (14) · France (12) · United Kingdom (12) · Canada (10) · Germany (9) · Belgium (8) · Brazil (7) · China (6) · Netherlands (6) · Italy (4) · Australia (2) · Georgia (2) · India (2) · Poland (2)
Brian P Brooks, M.D. (4) · Thomas Ciulla, MD (2) · Abraham Farhan (1) · Adnan Bayram, Professor (1) · Ahmad Mansour, MD (1) · Ahmed S Elwehidy, DM (1) · Ahmet Cakir, MD (1) · Alejandra Daruich, MD, PhD (1) · Arwa M Azmeh, Ph.D. (1) · Audrey Putoux, MD (1) · B. Wirostko, M.D. (1)
PMID 11146740, PMID 18812117, PMID 21168818, PMID 26315044, PMID 26603402, PMID 26766400, PMID 27312975, PMID 27373394, PMID 27980877, PMID 28957960, PMID 29515428, PMID 29643830, PMID 29698085, PMID 29718281, PMID 29862063, PMID 30041739, PMID 30225232, PMID 30559816, PMID 30855519, PMID 30877130, PMID 31215818, PMID 32169922, PMID 32890108, PMID 33497524, PMID 33542371, PMID 33547966, PMID 33844962, PMID 34061947, PMID 34247162, PMID 34281902, PMID 34534556, PMID 34610927, PMID 34629400, PMID 34653355, PMID 34935768, PMID 35201721, PMID 36243894, PMID 36575623, PMID 36765332, PMID 37369426, PMID 37418643, PMID 38709228, PMID 39121940, PMID 39814322, PMID 40062814, PMID 40208617, PMID 40339601, PMID 42204496, PMID 42490097, PMID 4662920
2018 (3), 2008 (1), P01CA034936 (1), R01AG076678 (1), R01DE022438 (1), U01EY032403 (1)