8 completed, 1 recruiting. 3 Phase 3, 2 Not applicable, 2 Phase 4, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 2, Recruiting 1 |
| Not applicable | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow polihexanide: new trials by email Literature Review of polihexanide trials Research Report on polihexanide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Decolonization Efficacy of Polyhexanide vs. Mupirocin Polyhexanide, Mupirocin and Chlorhexidine - Staphylococcus Aureus, Colonization, Asymptomatic | Phase 4 | Completed | Swiss Paraplegic Research, Nottwil | 24 | 2025-05-01 | 2026-07-08 |
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants Polyhexamethylene biguanide, Sodium Hypochlorite - Irreversible Pulpitis | Phase 2 | Completed | Altamash Institute of Dental Medicine | 60 | 2022-06-01 | 2023-02-21 |
| Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis PHMB 0.08%, Propamidine 0.1%, placebo - Acanthamoeba Keratitis | Phase 3 | Completed | SIFI SpA | 135 | 2017-08-13 | 2023-08-22 |
| Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects 0.04% PHMB, 0.06% PHMB, 0.08% PHMB - Acanthamoeba Keratitis | Phase 1 | Completed | SIFI SpA | 90 | 2015-11-01 | 2017-02-09 |
| Reduction of Postoperative Wound Infections by Antiseptica? Polihexanide; Serasept, NaCl; saline - Surgical Site Infection | Phase 3 | Completed | Johannes Lauscher | 456 | 2015-02-01 | 2019-08-13 |
| Antimicrobial Activity of Two Mouthwashes chlorhexidine, Polyhexamethylene biguanide, Sterile saline solution - Periimplantitis, Dental Plaque | Not applicable | Completed | Universidade do Vale do Sapucai | 30 | 2014-08-01 | 2017-01-10 |
| Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Polihexanide - Skin Diseases, Nail Diseases | Phase 4 | Completed | Universidad Complutense de Madrid | 50 | 2010-02-01 | 2011-04-07 |
| Effect of Prontosan Wound Irrigation Solution on Venous Ulcers Prontosan wound irrigation solution - Wound Care, Venous Ulcer Care | Not applicable | Completed | Calvary Hospital, Bronx, NY | 20 | 2009-06-01 | 2010-08-17 |
Acanthamoeba Keratitis (3) · Asymptomatic Infections (1) · Corneal Ulcer (1) · Dental Plaque (1) · Nail Diseases (1) · Nails, Ingrown (1) · Peri-Implantitis (1) · Periodontal Diseases (1) · Skin Diseases (1) · Staphylococcal Infections (1) · Surgical Wound Infection (1)
SIFI SpA (2) · Altamash Institute of Dental Medicine (1) · Calvary Hospital, Bronx, NY (1) · Jeremy Keenan, MD, MPH (1) · Johannes Lauscher (1) · Swiss Paraplegic Research, Nottwil (1) · Universidad Complutense de Madrid (1) · Universidade do Vale do Sapucai (1)
United Kingdom (2) · United States (2) · Brazil (1) · Germany (1) · India (1) · Italy (1) · Pakistan (1) · Poland (1) · Spain (1) · Switzerland (1)
Daniela Veiga, MD,PhD (1) · Gerami Seitzman, MD (1) · Jeremy Keenan, MD, MPH (1) · Johannes C Lauscher, MD (1) · John Dart, MD (1) · Martin Wendelken, RN, DPM (1) · Oscar M Alvarez, PhD (1)
PMID 31599810, PMID 33239413, PMID 35263172, PMID 37802392
2014 (1), UG1EY033284 (1)