2 completed, 1 recruiting. 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 2, Recruiting 1 |
Follow Acanthamoeba Keratitis: new trials by email Literature Review of Acanthamoeba Keratitis trials Research Report on Acanthamoeba Keratitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin - Acanthamoeba Keratitis, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 330 | 2022-08-03 | 2026-09-03 |
| Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis PHMB 0.08%, Propamidine 0.1%, placebo - Acanthamoeba Keratitis | Phase 3 | Completed | SIFI SpA | 135 | 2017-08-13 | 2023-08-22 |
Corneal Ulcer (1)
Amebiasis (3) · Corneal Diseases (3) · Eye Diseases (3) · Eye Infections (3) · Eye Infections, Parasitic (3) · Infections (3) · Keratitis (3) · Parasitic Diseases (3) · Protozoan Infections (3)
polihexanide (2) · Adrenal Cortex Hormones (1) · Corneal Cross-Linking (1) · Natamycin (1) · Rose Bengal (1) · chlorhexidine gluconate (1) · dibrompropamidine (1)
Jeremy Keenan, MD, MPH (1) · SIFI SpA (1) · University of California, San Francisco (1)
Brazil (2) · India (2) · United Kingdom (2) · Italy (1) · Poland (1) · United States (1)
Gerami Seitzman, MD (1) · Jennifer Rose-Nussbaumer, MD (1) · Jeremy Keenan, MD, MPH (1) · John Dart, MD (1) · Nicole Varnado, MPH (1) · Tom Lietman, MD (1)
PMID 37802392, PMID 39011096, PMID 39192339, PMID 41561665, PMID 42348235
UG1EY028518 (1), UG1EY033284 (1)