SIFI SpA: Clinical Trials

16 completed, 2 terminated, 1 active not recruiting, 1 unknown. 7 Not applicable, 2 Phase 3, 1 Phase 1, 1 Phase 2.

By phase and status

Phase	Trials	Status
Not applicable	7	Completed 4, Terminated 2, Unknown 1
Phase 3	2	Completed 2
Phase 1	1	Completed 1
Phase 2	1	Completed 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/mL Polihexanide as Part of the "Medicines in Special Situations" (Medicamentos en Situaciones Especiales) Program in Spain. PHMB 0.08% - Acanthamoeba Keratitis		Completed	SIFI SpA	23	2025-10-30	2026-06-22
Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/ml Polihexanide Acanthamoeba Keratitis		Completed	SIFI SpA	40	2024-09-30	2025-10-01
Observational Prospective Clinical Investigation on Monofocal Toric Intraocular Lens Mini Toric IOL - Cataract, Astigmatism		Completed	SIFI SpA	105	2024-04-24	2025-12-23
Observational, Prospective Clinical Investigation on Mini 4 Ready Intraocular Lens monofocal intraocular lens - Cataract		Active not recruiting	SIFI SpA	125	2024-01-08	2025-07-23
Clinical Investigation on the Use of Ophthalmic Solution Based on Sodium Hyaluronate in Treatment of Eye Discomfort Hyalistil Bio PF - Ocular Dryness		Completed	SIFI SpA	28	2023-03-14	2026-01-07
Investigation of Preservative-Free Ophthalmic Solution in Ocular Dryness Eyestil SYNFO - Dry Eye Syndromes		Completed	SIFI SpA	35	2023-02-23	2024-02-06
Safety and Efficacy of Two Different Concentrations (0.5% and 1%) of Progesterone Topical Gel Compared to Placebo in Patients Diagnosed With Moderate to Severe Dry Eye Syndrome Pro-ocular gel, Placebo gel - Dry Eye Disease	Phase 2	Completed	SIFI SpA	96	2021-02-18	2022-12-23
Trial Following Subjects Bilaterally Implanted With Mini Well Ready For 2 Years After the Second Eye Implant MINI WELL Ready (SIFI SpA, Italy) - Cataract		Completed	SIFI SpA	23	2020-10-26	2021-03-22
The Visual Performances of a Progressive Multifocal Intraocular Lens With Extended Depth of Focus EDOF Mini WELL Ready IOL - Cataract, Presbyopia		Completed	SIFI SpA	100	2020-09-02	2021-03-23
Non-comparative Trial Following Participants Implanted Bilaterally With Mini WELL Toric Ready Intraocular Lens for 6 Months After the Second Eye Implant (FUSION) Mini WELL Toric Ready intraocular lens - Bilateral Cataract, Astigmatism	Not applicable	Completed	SIFI SpA	58	2019-09-19	2023-04-18
A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi® Eyestil Plus® - Dry Eye Syndromes	Not applicable	Completed	SIFI SpA	96	2019-07-17	2022-12-23
To Demonstrate the Non-inferiority of Eyestil Protection® Compared to Vismed® in Terms of Clinical Performance Eyestil Protection® unidose - Dry Eye Syndrome	Not applicable	Terminated	SIFI SpA	21	2019-07-08	2022-05-09
Non-Inferiority Study Comparing MINI WELL READY® and FineVision® in Patients With Cataract Surgery MINI WELL READY ®, FINE VISION® - Cataract, Presbyopia	Not applicable	Terminated	SIFI SpA	8	2019-02-10	2020-09-03
A Comparison of the Visual Performance of Trifocal Versus Extended Depth of Focus Intraocular Lenses Intraocular lens - Cataract, Lenses	Not applicable	Unknown	Hashmanis Hospital	36	2018-11-05	2018-10-31
Clinical Study to Evaluate the Efficacy and Tolerability of an Anti-inflammatory/Antibiotic Treatment Following Ocular Cataract Extraction NETILDEX™ ophthalmic gel, NETILDEX™ eye drops solution - Cataract Extraction, Cataract	Phase 3	Completed	SIFI SpA	180	2017-10-15	2019-01-14
Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis PHMB 0.08%, Propamidine 0.1%, placebo - Acanthamoeba Keratitis	Phase 3	Completed	SIFI SpA	135	2017-08-13	2023-08-22
Non-comparative Study to Assess the Visual Performances and Safety of a Progressive Multifocal Intraocular Lens IOL MINI WELL READY - Cataract, Presbyopia	Not applicable	Completed	SIFI SpA	77	2016-08-01	2020-01-14
Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects 0.04% PHMB, 0.06% PHMB, 0.08% PHMB - Acanthamoeba Keratitis	Phase 1	Completed	SIFI SpA	90	2015-11-01	2017-02-09
Microbiological Evaluation of the Ocular Flora Before Cataract Surgery Disorders of the Eye Following Cataract Surgery		Completed	SIFI SpA	120	2014-04-01	2016-01-18
Efficacy of Topical 0.2% Xanthan Gum in Patients With Dry Eye carboxymethylcellulose, xanthan gum - Dry Eye	Not applicable	Completed	SIFI SpA	30	2013-09-01	2014-10-16

Conditions studied

Cataract (10)  ·  Dry Eye Syndromes (5)  ·  Acanthamoeba Keratitis (4)  ·  Presbyopia (4)  ·  Astigmatism (2)  ·  Disease Susceptibility (1)  ·  Vision Disorders (1)

Interventions

polihexanide (2)  ·  Lenses, Intraocular (1)  ·  dibrompropamidine (1)

Countries

Italy (10)  ·  Spain (5)  ·  France (4)  ·  Germany (3)  ·  Romania (2)  ·  Poland (1)  ·  United Kingdom (1)

Top investigators

Aldo Caporossi, MD, Prof. (1)  ·  Claudine Civiale (1)  ·  Davide Scollo, M.D. (1)  ·  Gianluca Stivale (1)  ·  John Dart, MD (1)  ·  Karl Knutsson, MD (1)  ·  Marc Labetoulle, MD; Pr (1)  ·  Marcello Santocono, MD (1)  ·  Pasquale Aragona, MD (1)  ·  Pierre Jean Pisella, MD, Pr (1)  ·  Sharif Hashmani, FCPS (1)

Results publications

PMID 10724823, PMID 13129879, PMID 16687454, PMID 16931257, PMID 17166341, PMID 18090888, PMID 19643497, PMID 22553713, PMID 33239413, PMID 37802392, PMID 39984804, PMID 42141248, PMID 42376480

NIH funding

2016 (1), 2019 (1)