30 completed, 7 recruiting, 7 unknown, 5 withdrawn. 59 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 59 | Completed 30, Recruiting 7, Unknown 7, Withdrawn 5, Active not recruiting 4, Terminated 4, Not yet recruiting 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanisms of Weight Loss: Tirzepatide vs Semaglutide Tirzepatide, Semaglutide - Obesity (Disorder) | Phase 4 | Recruiting | McMaster University | 80 | 2026-10-31 | 2026-10-28 |
| SAFE (Self-Administration of Flumist to ImprovE Uptake: A Household-Based Cluster Randomized Trial) LAIV FLUMIST - Influenza (Healthy Volunteers) | Phase 4 | Not yet recruiting | McMaster University | 966 | 2026-10-15 | 2026-07-31 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty - A Feasibility Study Ropivacaine, Normal saline - Arthroplasty, Replacement, Knee | Phase 4 | Withdrawn | McMaster University | 2026-01-15 | 2026-06-04 | |
| Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based Treatment Gelclair Oral Mouth Rinse - Squamous Cell Carcinoma, Oropharyngeal Cancers | Phase 4 | Active not recruiting | McMaster University | 29 | 2025-12-15 | 2026-07-13 |
| Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy Semaglutide Pen Injector - Prostate Cancer | Phase 4 | Active not recruiting | Hamilton Health Sciences Corporation | 20 | 2025-07-02 | 2026-09-14 |
| JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP) - Obesity (Disorder) | Phase 4 | Recruiting | McMaster University | 74 | 2025-06-18 | 2026-01-14 |
| Therapeutic Relevance of Abnormal Airway Morphology in Asthma Inhaled corticosteroid (ICS), Oral Corticosteroid (OCS) - Asthma | Phase 4 | Recruiting | McMaster University | 242 | 2025-06-02 | 2025-09-11 |
| Kinematic and Mechanical Alignment Randomized Trial Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty - Total Knee Arthroplasty, Osteoarthritis | Phase 4 | Recruiting | McMaster University | 260 | 2025-02-20 | 2025-05-08 |
| Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT Bavarian Nordic smallpox vaccine, Typhoid VI Polysaccharide Vaccine Injectable Solution - Monkeypox | Phase 4 | Active not recruiting | McMaster University | 3000 | 2024-09-17 | 2026-08-12 |
| Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) Celestone + placebo, Celestone + Celestone - Preterm Birth, Premature Birth | Phase 4 | Recruiting | McMaster University | 3254 | 2023-07-20 | 2026-01-07 |
| Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial Faricimab - Diabetic Macular Edema | Phase 4 | Active not recruiting | McMaster University | 446 | 2023-05-01 | 2026-04-17 |
| Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) Escitalopram, Brexpiprazole - Major Depressive Disorder | Phase 4 | Recruiting | Nova Scotia Health Authority | 400 | 2023-01-20 | 2026-06-11 |
| Continuation of Metformin to Improve And Keep Peri-operative Glycemic Control Metformin, Placebo - Diabetes Mellitus Type 2 | Phase 4 | Withdrawn | McMaster University | 2022-01-01 | 2026-07-10 | |
| Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases Mepolizumab, Normal Saline - Chronic Cough, Eosinophilic Bronchitis | Phase 4 | Completed | McMaster University | 46 | 2021-12-14 | 2025-09-16 |
| Combination Therapy With Fecal Microbiota Transplantation and Vedolizumab for Induction of Ulcerative Colitis Fecal microbiota transplantation - Ulcerative Colitis | Phase 4 | Completed | McMaster University | 6 | 2021-05-01 | 2024-11-20 |
| COVID-19 Vaccine For Indirect Protection COVID-19 Vaccination, Usual care - Vaccine Preventable Disease | Phase 4 | Withdrawn | McMaster University | 2021-04-15 | 2021-05-14 | |
| Improved Adherence With Extended Venous Thromboembolism Prophylaxis After Major Cancer Surgery Apixaban 2.5 milligram - Neoplasms Malignant, Surgery | Phase 4 | Completed | McMaster University | 53 | 2021-02-22 | 2022-04-22 |
| Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma Reslizumab - Asthma; Eosinophilic | Phase 4 | Completed | McMaster University | 10 | 2021-02-10 | 2024-01-25 |
| Medical Masks vs N95 Respirators for COVID-19 Medical Mask, N95 respirator - Coronavirus, N95 | Phase 4 | Completed | McMaster University | 1009 | 2020-03-01 | 2023-01-12 |
Showing 20 of 59. Sign in to see all of them.
Influenza, Human (8) · Asthma (3) · Crohn Disease (3) · Depressive Disorder, Major (3) · Obsessive-Compulsive Disorder (3) · Surgical Wound Infection (3) · Anxiety Disorders (2) · Chronic Cough (2) · Colitis, Ulcerative (2) · Diabetes Mellitus, Type 2 (2) · Fractures, Open (2) · Heart Failure (2) · Hip Fractures (2) · Obesity (2) · Phobia, Social (2)
Influenza Vaccines (3) · semaglutide (3) · Calcium Carbonate (2) · Clonidine (2) · Fentanyl (2) · Oseltamivir (2) · Prednisone (2) · Pregabalin (2) · Saline Solution (2) · Standard of Care (2) · Topiramate (2) · 2019-nCoV Vaccine mRNA-1273 (1) · Adalimumab (1) · Adrenal Cortex Hormones (1) · Alendronate (1)
Canada (48) · United States (4) · China (3) · Uganda (3) · Mozambique (2) · Nigeria (2) · Philippines (2) · Saudi Arabia (2) · Australia (1) · Cameroon (1) · Democratic Republic of the Congo (1) · Egypt (1) · India (1) · Israel (1) · Kenya (1)
Michael Van Ameringen, MD, FRCPC (4) · Claudio N Soares, MD, PhD (2) · Gerard Slobogean, MD (2) · Mark B Loeb, MD (2) · Mark Loeb, MD (2) · Mark Loeb, MD, MSc. (2) · Mohit Bhandari, MD (2) · Sheila Sprague, PhD (2) · Alexandra Papaioannou, M.D. (1) · Alexandra Papaioannou, M.D., M.Sc. (1) · Andreas Freitag, M.D. (1) · Cagla Eskicioglu, MD, MSc (1) · Colin E Webber, PhD CCPM (1) · Dan Stein (1) · Darryl Leong, MBBs,MPH,PhD,FRACP,FESC (1)
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