27 completed, 1 recruiting, 1 terminated, 1 unknown. 22 Phase 1, 4 Phase 2, 2 Not applicable, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 22 |
| Phase 2 | 4 | Completed 4 |
| Not applicable | 2 | Recruiting 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Palatability Study of Five Formulations of Benzydamine HCl Lozenges benzydamine HCl - Healthy Volunteers, Palatability | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 120 | 2025-04-13 | 2025-09-30 |
| The Effectiveness of Heat Treatment on Knee Pain in Patients With Osteoarthritis - an International, Multicenter Clinical Investigation Knee Heatwraps - Pain Management, Osteoarthritis | Not applicable | Recruiting | Aziende Chimiche Riunite Angelini Francesco S.p.A | 80 | 2024-10-21 | 2025-09-08 |
| Efficacy and Safety of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia in Pediatric Population Chloroprocaine 3% eye gel, Oxybuprocaine Hydrochloride 4 Mg/mL Eye Drops - Local Anesthetic | Phase 3 | Completed | Sintetica SA | 74 | 2024-05-23 | 2026-03-09 |
| Clinical Performance and Safety of Suture-TOOL Suture-TOOL - Laparotomy, Incisional Hernia | Not applicable | Unknown | Suturion AB | 38 | 2023-01-10 | 2023-01-23 |
| Study to Evaluate the Safety and Concentrations of Monoclonal Antibody Against Virus That Causes COVID-19 Disease. MAD0004J08, Placebo - COVID-19 Virus Disease | Phase 1 | Completed | Toscana Life Sciences Sviluppo s.r.l. | 30 | 2021-03-01 | 2022-04-27 |
| Riluzole Orodispersible Film Replicate Bioavailability Riluzole 50 mg orodispersible film, Rilutek® 50 mg riluzole tablets - Healthy Participants | Phase 1 | Completed | Cross Research S.A. | 54 | 2021-01-15 | 2025-05-02 |
| Bioavailability Study of 300 mg Trazodone Hydrochloride (New Polymer) vs. 300 mg Trazodone Hydrochloride (Contramid® Prolonged-release Tablets) Under Fasting Conditions Trazodone HCl - new polymer, Trazodone HCl - Contramid® - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 28 | 2020-02-17 | 2021-11-29 |
| Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome RP101 - Dry Eye Syndromes | Phase 2 | Completed | Redwood Pharma AB | 104 | 2019-01-18 | 2019-12-20 |
| Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures 30 mg Paracetamol 3% (1 mL), 60 mg Paracetamol 3% (2 mL), 90 mg Paracetamol 3% (3 mL) - Pain, Postoperative | Phase 2 | Completed | Sintetica SA | 60 | 2018-08-06 | 2021-06-24 |
| Bioequivalence of Ketoprofen Oral Gel vs Ketoprofen Lysine Salt as Granules for Oral Solution Ketoprofen Lysine, Ketoprofen Oral Product - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 36 | 2018-07-23 | 2020-12-21 |
| Bioequivalence of Flurbiprofen Lozenge vs Strepfen Flurbiprofen Test 8.75 MG, Flurbiprofen Reference 8.75 MG - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 24 | 2018-06-19 | 2020-12-17 |
| A Novel Mouthwash Formulation CTP/BNZ With Mucus Adhesive Polymer Cetylpyridinium Chloride 0.05% + Benzydamine HCl 0.15% + mucus adhesive polymer, Cetylpyridinium Chloride 0.05% + Benzydamine HCl 0.15% - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 26 | 2017-11-14 | 2020-08-05 |
| Safinamide Steady State Interaction With Rosuvastatin 100 mg safinamide, 20 mg rosuvastatin calcium period 1, 20 mg rosuvastatin calcium period 2 - Healthy | Phase 1 | Completed | Cross Research S.A. | 24 | 2017-05-22 | 2017-08-01 |
| Effects of Three Single Oral Doses of Trazodone on the QTc Interval Duration in Healthy Volunteers Trazodone 20 mg, Trazodone 60 mg, Trazodone 140 mg - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 20 | 2017-03-20 | 2020-07-31 |
| Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section Chloroprocaine, Ropivacaine - Unplanned Caesarean Section | Phase 3 | Terminated | Sintetica SA | 16 | 2016-10-01 | 2023-11-21 |
| Crossover, Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup SCMC-lys powder 1.35 g, Fluifort® syrup - Bronchitis | Phase 1 | Completed | Dompé Farmaceutici S.p.A | 30 | 2016-07-04 | 2024-11-18 |
| Bioequivalence Study of Ibuprofen 200 mg/5 mL Oral Suspension vs. MOMENT 200 mg Coated Tablet Ibuprofen 200 mg/5 mL oral suspension, MOMENT 200 mg coated tablet - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 60 | 2016-06-01 | 2016-09-15 |
| Bioequivalence Study of Ibuprofen 400 mg/10 mL Oral Suspension vs. MOMENTACT 400 mg Film-coated Tablet Ibuprofen 400 mg/10 mL oral suspension, MOMENT 400 mg coated tablet - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 60 | 2016-05-01 | 2016-09-15 |
| Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg Paracetamol 1000 mg/codeine phosphate hemihydrate 30 mg tablet, Paracetamol 500 mg/codeine phosphate hemihydrate 30 mg tablet - Healthy | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 46 | 2016-04-01 | 2016-09-16 |
| Tolerability and Pharmacokinetic Study of Econazole Nitrate Plus Benzydamine HCl Vaginal Pessary Econazole nitrate 150 mg plus Benzydamine HCl 6 mg vaginal pessary, Placebo plus Econazole nitrate 150 mg vaginal pessary, Placebo plus Benzydamine HCl 6 mg vaginal pessary - Healthy Women | Phase 1 | Completed | Aziende Chimiche Riunite Angelini Francesco S.p.A | 49 | 2016-03-04 | 2017-02-07 |
Showing 20 of 30. Sign in to see all of them.
Dry Eye Syndromes (2) · Neuralgia (2) · Acquired Immunodeficiency Syndrome (1) · Agnosia (1) · Anthrax (1) · Bronchitis (1) · COVID-19 (1) · Dysmenorrhea (1) · Headache (1) · Incisional Hernia (1) · Keratoconjunctivitis Sicca (1) · Leukemia, Hairy Cell (1) · Osteoarthritis (1) · Pain (1) · Pain, Postoperative (1)
Benzydamine (4) · Ibuprofen (3) · Acetaminophen (2) · Econazole (2) · Solutions (2) · Suspensions (2) · Trazodone (2) · chloroprocaine (2) · safinamide (2) · Cetylpyridinium (1) · Diclofenac (1) · Filgrastim (1) · Injections (1) · MAD0004J08 (1) · Metered Dose Inhalers (1)
Switzerland (22) · Austria (2) · Italy (2) · Belgium (1) · Germany (1) · Hungary (1) · South Africa (1) · Sweden (1)
Milko Radicioni, MD (14) · Andrea Paolini (1) · Antonio Rusca, MD (1) · Antonio Rusca, MD, FMH (1) · Claudio Camponovo, MD (1) · Daniel R Malan, MD (1) · Marc Van de Velde, MD (1) · Marcus Edelhamre, MD Phd (1) · Milko M Radicioni, MD PhD (1) · Milko Radicioni (1) · Ruggero G Fariello, MD FAAN (1)
PMID 21615456, PMID 24555723, PMID 30944103, PMID 31549201, PMID 32410819, PMID 32488885, PMID 33710587, PMID 34473343, PMID 35477725, PMID 39845163