20 completed, 3 withdrawn, 2 recruiting, 2 terminated. 7 Phase 3, 6 Not applicable, 6 Phase 4, 5 Phase 1, 3 Phase 2.
Follow Metered Dose Inhalers: new trials by email Literature Review of Metered Dose Inhalers trials Research Report on Metered Dose Inhalers
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation Budesonide/Glycopyrronium/Formoterol Fumarate, Placebo, Metered dose inhaler - Chronic Obstructive Pulmonary Disease, Hyperinflation | Phase 4 | Recruiting | AstraZeneca | 56 | 2025-11-24 | 2026-09-18 |
| Effect of Spacer Use on Exacerbation Risk in High-Risk Older Adults With Chronic Airway Diseases Receiving Triple Therapy pMDI Triple Inhaler and Spacer, pMDI Triple Inhaler Only - Asthma, COPD | Not applicable | Recruiting | First Affiliated Hospital of Ningbo University | 380 | 2025-06-17 | 2026-06-26 |
| Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic Rhinitis Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg, Oxymetazoline 0.05% nasal solution - Persistent Allergic Rhinitis | Phase 4 | Completed | Dr. Behcet Uz Children's Hospital | 76 | 2025-01-02 | 2026-05-18 |
| Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution, Vibrating Mesh Nebulizer, Metered Dose Inhaler - Chronic Obstructive Pulmonary Disease | Phase 1 | Unknown | Polarean, Inc. | 6 | 2024-02-01 | 2024-02-21 |
| Comparison of Nebulizers vs Metered-Dose Inhalers With Spacer Device For Treatment Of Childhood Wheeze Metered Dose Inhaler With Spacer Device - Childhood Asthma With Acute Exacerbation | Not applicable | Completed | Khyber Teaching Hospital | 160 | 2023-12-10 | 2025-03-11 |
| Clinical Evaluation of Infection Control to Knee Periprosthetic Joint Infection (PJI) -United Cellbrick Knee Spacer Novel spacer, Spacer - Knee; Infection, Joint | Not applicable | Unknown | Chang Gung Memorial Hospital | 10 | 2023-08-01 | 2024-04-17 |
| Effectiveness of Fluticasone Furoate/ Umeclidinium/ Vilanterol (FF/UMEC/VI) Using the Connected Inhaler System (CIS) as Compared With Fluticasone Proprionate/ Salmeterol (FP/SAL) Plus Tiotropium (TIO) in Inadequately Controlled Asthma FF/UMEC/VI, FP/SAL, Tiotropium - Asthma | Phase 3 | Withdrawn | GlaxoSmithKline | 2019-01-18 | 2019-03-25 | |
| Salbutamol Administration by Nebulizer Versus Metered Dose Inhaler With Spacer in Asthma in Children Nebulizer, Salbutamol, Metered dose inhaler and spacer - Bronchial Asthma | Phase 3 | Completed | Suez Canal University | 60 | 2018-05-15 | 2019-04-04 |
| Sensor-augmented Pump Versus Multiple Daily Injections With Degludec as Basal Insulin for Insulin Therapy in Type 1 Diabetes CGM+CSII, MDI with degludec - Diabetes Mellitus, Type 1 | Not applicable | Completed | Azienda Ospedaliero-Universitaria Careggi | 28 | 2018-04-01 | 2022-07-26 |
| A Pilot Study of Danirixin for Disease Progression in Chronic Obstructive Pulmonary Disease (COPD) Danirixin 35 mg tablets, Placebo, Metered dose inhaler (MDI) sensor device - Pulmonary Disease, Chronic Obstructive | Phase 2 | Terminated | GlaxoSmithKline | 54 | 2017-10-16 | 2020-07-31 |
| A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers Symbicort pMDI with spacer device, Symbicort pMDI without spacer device - Study is Being Conducted in Healthy Volunteers | Phase 1 | Completed | AstraZeneca | 50 | 2016-11-04 | 2018-08-20 |
| A Phase III Parallel Group Study, Comparing the Efficacy, Safety and Tolerability of the Fixed Dose Combination (FDC) of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol (FF/UMEC/VI) With the FDC of FF/VI in Subjects With Inadequately Controlled Asthma FF/UMEC/VI (100/31.25/25) mcg, FF/UMEC/VI (100/62.5/25) mcg, FF/UMEC/VI (200/31.25/25) mcg - Asthma | Phase 3 | Completed | GlaxoSmithKline | 2436 | 2016-10-13 | 2021-03-26 |
| Combined Glucocorticoid Adrenergic Therapy For Wheezy Preschool Children Beclomethasone, Beclomethasone and Salbutamol, Placebo - Wheeze | Phase 4 | Withdrawn | University of Calgary | 2016-04-01 | 2016-11-15 | |
| A Randomized Trial Comparing Metered Dose Inhalers and Breath Actuated Nebulizers Metered Dose Inhaler, Breath Actuated Nebulizer - Asthma | Not applicable | Completed | Le Bonheur Children's Hospital | 980 | 2014-10-01 | 2017-08-15 |
| A Pharmacokinetic/Pharmacodynamic Inhaler Comparison Study in Healthy Volunteers Fluticasone/formoterol BAI, Formoterol, Fluticasone/formoterol PMDI without spacer - Asthma | Phase 1 | Completed | Mundipharma Research Limited | 125 | 2014-08-01 | 2015-09-28 |
| ELLIPTA™ vs. MDI Inhaler Preference Study, in Adult Subjects With Asthma ELLIPTA inhaler, Placebo Inhalation Aerosol (MDI) - Asthma | Completed | GlaxoSmithKline | 288 | 2014-06-01 | 2016-06-08 | |
| A Study to Assess the Systemic Exposure of FLIXOTIDE™ (Fluticasone Propionate) and SERETIDE™ (Fluticasone Propionate and Salmeterol) Given With VENTOLIN™ Mini-Spacer Compared to the Aerochamber Plus Spacer VENTOLIN Mini-Spacer, Aerochamber Plus spacer - Asthma | Phase 1 | Completed | GlaxoSmithKline | 21 | 2014-01-29 | 2018-06-19 |
| A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants Ages 4-11 Years Old With Persistent Asthma Beclomethasone dipropionate BAI, Placebo BAI, albuterol/salbutamol 90 mcg - Asthma | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 628 | 2013-12-01 | 2021-11-09 |
| Efficacy and Safety of Mometasone Furoate for Persistent Asthma Previously Treated With Low-Dose Inhaled Glucocorticosteroids (ICS) (Study P06115) SCH 32088 mometasone furoate (MF) metered-dose inhaler, Placebo metered-dose inhaler BID - Asthma | Phase 3 | Withdrawn | Organon and Co | 2012-06-01 | 2022-02-16 | |
| A Study of Mometasone Furoate Metered Dose Inhaler in Children With Persistent Asthma (P04223) Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 25 mcg, Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 50 mcg, Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg - Asthma | Phase 2 | Completed | Organon and Co | 583 | 2012-01-25 | 2024-06-17 |
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Asthma (18) · Pulmonary Disease, Chronic Obstructive (6) · Anthrax (2) · Diabetes Mellitus, Type 1 (1) · Disease Progression (1) · Infections (1) · Medication Adherence (1) · Nasal Obstruction (1) · Respiratory Sounds (1) · Rhinitis, Allergic (1) · Spinal Stenosis (1) · Status Asthmaticus (1)
GlaxoSmithKline (5) · AstraZeneca (3) · Organon and Co (3) · Akron Children's Hospital (1) · Azienda Ospedaliero-Universitaria Careggi (1) · Boehringer Ingelheim (1) · Brian J Lipworth (1) · Chang Gung Memorial Hospital (1) · Chiesi Farmaceutici S.p.A. (1) · Dr. Behcet Uz Children's Hospital (1) · First Affiliated Hospital of Ningbo University (1) · Imperial College London (1) · Khyber Teaching Hospital (1) · Le Bonheur Children's Hospital (1) · Mundipharma Research Limited (1)
United Kingdom (7) · United States (6) · Germany (3) · Poland (3) · Canada (2) · Italy (2) · Russia (2) · Argentina (1) · Australia (1) · Brazil (1) · China (1) · Croatia (1) · Egypt (1) · Hungary (1) · Japan (1)
Alaa Zeitoun, Prof (1) · Antonio Rusca, MD, FMH (1) · Ariel Teper, MD (1) · Arooj Khan, MBBS (1) · Arun Nair (1) · Brian J Lipworth (1) · Dr Rainard Fuhr, Dr. med (1) · Jaime Mata, PhD (1) · Jose A Rizzo, PhD, MD (1) · Kimberly A Spoonhower, M.D. (1) · Mark A Snider, DO (1) · O S Usmani, MD, PhD (1) · Piotr Kuna, MD PhD (1)
PMID 36472162, PMID 21240480, PMID 21615456, PMID 24019197, PMID 27740721, PMID 28710850, PMID 32918892, PMID 33598874, PMID 34162298, PMID 37385337, PMID 38309696, PMID 41442024, PMID 42843159
2016 (2), 2008 (1), 2017 (1), 2025 (1)