15 completed, 4 not yet recruiting, 2 recruiting, 1 enrolling by invitation. 22 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 22 | Completed 15, Not yet recruiting 4, Recruiting 2, Enrolling by invitation 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Pre-Procedural CPC and Zinc Mouthwash in Reducing Dental Aerosols 0.09% CPC + Zinc Lactate Mouthwash, 0.2% Chlorhexidine Mouthwash, Water - Bacterial Contamination | Phase 4 | Not yet recruiting | Colgate Palmolive | 60 | 2026-10-08 | 2026-10-19 |
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Enamel Lesion Detection With New DX Tool BlueCheck, Prevident 5000ppm Booster Plus Toothpaste - Enamel Lesions, Caries | Phase 4 | Not yet recruiting | Colgate Palmolive | 5 | 2026-09-15 | 2026-09-14 |
| Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses. Stannous Fluoride Toothpaste (SnF) - Gingival Inflammation | Phase 4 | Not yet recruiting | Colgate Palmolive | 20 | 2026-09-01 | 2026-09-03 |
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash - Diabetes Type 2, Periodontal Disease | Phase 4 | Enrolling by invitation | Colgate Palmolive | 10000 | 2026-05-26 | 2026-09-03 |
| Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis sodium monofluorophosphate toothpaste - Gingivitis, Plaque | Phase 4 | Recruiting | Colgate Palmolive | 100 | 2026-04-20 | 2026-05-29 |
| 6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health Test Mouthrinse, Control Mouthrinse - Gingivitis, Dental Plaque Accumulation | Phase 4 | Recruiting | Colgate Palmolive | 90 | 2026-01-28 | 2026-02-17 |
| Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis Mouthwash, Floss, Toothbrush - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 228 | 2025-07-07 | 2025-10-30 |
| Efficacy of a Sonic Toothbrush and 8% Arginine Toothpaste in Reducing Dentinal Hypersensitivity 8.0% Arginine Dentifrice, Electric Sonic Toothbrush, Adult Soft Bristle Manual Toothbrush - Dentin Sensitivity, Dentin Hypersensitivity | Phase 4 | Completed | Colgate Palmolive | 80 | 2021-12-06 | 2026-10-16 |
| Baseline Oral Health Study: UnCoVer the Connections to General Health Subgingival chlorhexidine irrigation, Dental Supplies, Periodonal Treatment - Cardiovascular Diseases, Diabetes Type 2 | Phase 4 | Completed | University of North Carolina, Chapel Hill | 786 | 2021-09-28 | 2026-02-12 |
| Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste Colgate Total SF, Colgate Cavity Protection toothpaste - Gingivitis | Phase 4 | Completed | Colgate Palmolive | 88 | 2019-03-06 | 2022-09-27 |
| Clinical Study to Assess Therapeutic Delay and Resolution of Induced Gingivitis Stannous Fluoride Toothpaste, Colgate fluoride toothpaste - Gingivitis | Phase 4 | Completed | Colgate Palmolive | 26 | 2018-12-22 | 2023-02-16 |
| Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers Triclosan Containing Toothpaste, Triclosan Free Toothpaste - Periodontal Disease, Systemic Inflammatory Markers | Phase 4 | Completed | Colgate Palmolive | 303 | 2015-06-01 | 2019-02-22 |
| Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Fluoride Varnish, Control Group - Dental Caries | Phase 4 | Completed | Universidad Iberoamericana | 180 | 2015-03-01 | 2016-11-04 |
| Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment In-office and at home Colgate sensitive pro-relief - CSPR, In-office Villevie® prophy paste + Colgate Toothpaste, Non-surgical periodontal treatment - Dentin Sensitivity, Periodontal Diseases | Phase 4 | Completed | University of Campinas, Brazil | 60 | 2014-08-01 | 2015-06-03 |
| Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 179 | 2014-06-01 | 2016-03-30 |
| The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 129 | 2014-06-01 | 2016-03-30 |
| Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria Total Flavor option 1, Total Flavor option 2, Placebo toothpaste: Crest Cavity Protection toothpaste - Oral Bacteria Levels in the Mouth | Phase 4 | Completed | Colgate Palmolive | 128 | 2014-01-01 | 2016-04-15 |
| Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Colgate Cavity Protection toothpaste, Colgate Total toothpaste, Parodontax toothpaste - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 135 | 2013-03-01 | 2019-05-20 |
| Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Administration of Metronidazole plus Amoxicillin - Chronic Periodontitis, Clinical and Microbiological Effects | Phase 4 | Completed | University of Chile | 42 | 2010-01-01 | 2016-06-16 |
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Gingivitis (12) · Dental Plaque (4) · Periodontal Diseases (4) · Dental Caries (2) · Dentin Sensitivity (2) · Diabetes Mellitus, Type 2 (2) · Cardiovascular Diseases (1) · Chronic Periodontitis (1) · Plaque, Amyloid (1) · Pneumonia (1)
hydrated silica gel-based toothpaste (7) · Triclosan (4) · Cetylpyridinium (2) · Mouthwashes (2) · Toothpastes (2) · Zinc (2) · cytidylyl-(3'-5')-cytidine (2) · Amoxicillin (1) · Centers for Disease Control and Prevention, U.S. (1) · Control Groups (1) · Dental Devices, Home Care (1) · Ethanol (1) · Sodium Fluoride (1) · Tin Fluorides (1) · Water (1)
United States (12) · Brazil (2) · Canada (1) · Chile (1) · Germany (1) · Thailand (1)
David Paquette, DMD (1) · Enilson A Sallum, PhD (1) · Eva-Maria Axmann (1) · Gabriella John, MS (1) · Jeffery Milleman, DDS, MPA (1) · Michael Glogauer, DDS/PhD (1) · Ninoska Abreu (1) · Sara G Grossi, DDS (1) · Saroja Voruganti, PhD (1) · Terdphong Triratana (1) · Yimimg Li, DDS, PhD (1) · Yun Po Zhang, Doctoral (1)