38 completed. 38 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 38 | Completed 38 |
| Phase 2 | 7 | Completed 7 |
Follow Propofol: new trials by email Literature Review of Propofol trials Research Report on Propofol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Procedural Sedation in TEE Remimazolam, Propofol - Anesthesia | Phase 1 | Completed | University of Alabama at Birmingham | 105 | 2025-02-25 | 2026-11-10 |
| Effects of Anesthetic Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries ketamine and dexmeditomidine combination, Propofol - Tethered Cord | Phase 1 | Completed | Cairo University | 46 | 2022-10-30 | 2024-02-07 |
| Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users HSK3486, Propofol, Placebo - General Anesthesia | Phase 1 | Completed | Haisco-USA Pharmaceuticals, Inc. | 42 | 2022-08-16 | 2023-10-13 |
| Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users HSK3486, propofol, Placebo - General Anesthesia | Phase 1 | Completed | Haisco-USA Pharmaceuticals, Inc. | 43 | 2022-08-16 | 2026-02-23 |
| Effect of Anesthetics on Troponin I and ะก-reactive Protein Propofol, Isoflurane, Sevoflurane - Mitral Valve Insufficiency, Aortic Valve Insufficiency | Phase 1 | Completed | Astana Medical University | 255 | 2021-11-30 | 2023-06-05 |
| A Study of Danavorexton in Anesthetized Adults Danavorexton, Danavorexton Placebo, Propofol - Healthy Volunteers | Phase 1 | Completed | Takeda | 28 | 2021-09-28 | 2022-05-10 |
| The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery Propofol, Isoflurane, Sevoflurane - Coronary Artery Disease, Mitral Valve Insufficiency | Phase 1 | Completed | Astana Medical University | 89 | 2021-01-22 | 2023-01-25 |
| Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I Propofol, Electroencephalography (EEG), Slow-Wave Activity - Treatment-resistant Depression | Phase 1 | Completed | Washington University School of Medicine | 16 | 2021-01-14 | 2026-04-23 |
| Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics Ketamine/ propofol, Dexmedetomidine - Vital Signs | Phase 1 | Completed | Ain Shams University | 40 | 2020-10-10 | 2022-08-05 |
| Memory & Conditioning Under Anesthesia Dexmedetomidine, Propofol, Fentanyl - Anesthesia, Pain | Phase 1 | Completed | Keith M Vogt | 92 | 2020-07-30 | 2025-04-18 |
| A Study to Evaluate the Differences in Pharmadynamics, Pharmacokinetics, and Safety Between Ciprofol and Propofol Ciprofol, Propofol - Anesthesia | Phase 1 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 18 | 2020-05-26 | 2020-11-20 |
| A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 HSK3486, Propofol - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2019-01-09 | 2020-01-09 |
| The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery Propofol, Sevoflurane - End Stage Renal Disease, Hemodialysis Complication | Phase 1 | Completed | Kaohsiung Medical University Chung-Ho Memorial Hospital | 47 | 2017-09-11 | 2021-09-05 |
| Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses Propofol, Remifentanil - Sedative Overdose | Phase 1 / Phase 2 | Completed | Parc de Salut Mar | 30 | 2017-06-13 | 2022-09-30 |
| Anesthetics to Prevent Lung Injury in Cardiac Surgery Sevoflurane, Propofol - Inflammatory Lung Injury, Ischemia-Reperfusion Lung Injury | Phase 1 / Phase 2 | Completed | Beth Israel Deaconess Medical Center | 51 | 2017-06-09 | 2021-05-05 |
| Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery Midazolam Hydrochloride, Fentanyl, Ketamine - Anesthesia, Tooth Extraction | Phase 1 | Completed | Albert Einstein College of Medicine | 73 | 2016-10-04 | 2026-03-27 |
| Burst Suppression Anesthesia for Treatment of Severe Depression Diprivan - Major Depressive Disorder | Phase 1 | Completed | University of Utah | 11 | 2016-10-01 | 2021-06-02 |
| Pilot Study of Bioequivalence of Cudafol(R) and Diprivan(R) Administered as Single Intravenous Doses in Healthy Subjects Cudafol(R) (propofol, 1% [10 mg/mL]), Diprivan(R) (propofol, 1% [10 mg/mL]) - Healthy Subjects | Phase 1 | Completed | Cuda Anesthetics, LLC | 8 | 2016-03-01 | 2016-04-21 |
| Renal Function During Pediatric Anesthesia Sevoflurane, propofol - Renal Failure, Anesthesia | Phase 1 | Completed | Uppsala University | 24 | 2015-10-01 | 2020-11-04 |
| Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects. HSK3486, Propofol - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 25 | 2015-04-22 | 2019-07-31 |
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Aortic Valve Insufficiency (2) · Inflammation (2) · Mitral Valve Insufficiency (2) · Sepsis (2) · Alzheimer Disease (1) · Amnesia (1) · Atrial Fibrillation (1) · Brain Injuries (1) · Cognitive Dysfunction (1) · Coronary Artery Disease (1) · Depressive Disorder, Major (1) · Depressive Disorder, Treatment-Resistant (1) · Heart Diseases (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1)
Sichuan Haisco Pharmaceutical Group Co., Ltd (3) · Stanford University (3) · Astana Medical University (2) · Eisai Inc. (2) · Haisco-USA Pharmaceuticals, Inc. (2) · Southeast University, China (2) · University Medical Centre Ljubljana (2) · Ain Shams University (1) · Albert Einstein College of Medicine (1) · Asan Medical Center (1) · Beth Israel Deaconess Medical Center (1) · Cairo University (1) · Carmelo Graffagnino (1) · Cuda Anesthetics, LLC (1) · Duke University (1)
United States (18) · China (4) · Egypt (2) · Kazakhstan (2) · Slovenia (2) · Sweden (2) · Canada (1) · South Korea (1) · Spain (1) · Taiwan (1) · Thailand (1)
Alibek Kh Mustafin, Professor (2) · Iztok Potocnik, MD, MSC (2) · Jerry Ingrande, M.D., M.S. (2) · Alaa Ismail, MD (1) · Ales Jerin, PHD (1) · Anthony Doufas (1) · Ben Palanca, MD PhD (1) · Benno von Bormann, MD (1) · Blaz Karpe, PHD (1) · Brian O'Gara, MD (1) · Byung-Moon Choi, M.D. (1) · Carmelo Graffagnino, MD (1) · Christa Nagy (1)
PMID 17621602, PMID 19417610, PMID 21399490, PMID 25559834, PMID 26056838, PMID 27001425, PMID 27079717, PMID 29181002, PMID 30260415, PMID 31151474, PMID 33079873, PMID 38296753
K23GM100273 (1), R35GM146822 (1), U01MH128483 (1)