38 completed, 6 unknown, 5 terminated, 3 not yet recruiting. 55 Phase 1, 15 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 55 | Completed 38, Unknown 6, Terminated 5, Not yet recruiting 3, Withdrawn 2, Recruiting 1 |
| Phase 2 | 15 | Completed 7, Unknown 3, Not yet recruiting 2, Withdrawn 2, Terminated 1 |
Follow Propofol: new trials by email Literature Review of Propofol trials Research Report on Propofol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery Propofol (Astra-Zeneca), propofol and dexmetomidine - Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery | Phase 1 / Phase 2 | Not yet recruiting | Kafrelsheikh University | 60 | 2026-09-01 | 2026-09-01 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| a Comparive Study of Ketamine-Propofol Versus Dexmedetomidine-Propofol Sedation in Pediatric Patients Undergoing Cardiac Catheterization for Device Closure of Simple Left-to-right Shunts Ketamine + propofol, Dexmedetomidine + propofol - Sedation and Analgesia | Phase 1 | Recruiting | Ain Shams University | 124 | 2025-10-22 | 2026-06-25 |
| The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy Remimazolam, Propofol - Remimazolam Besylate, Thoracoscopic Lobectomy | Phase 1 / Phase 2 | Not yet recruiting | Jinqiao Qian | 150 | 2025-08-01 | 2025-07-25 |
| Comparison of Procedural Sedation in TEE Remimazolam, Propofol - Anesthesia | Phase 1 | Completed | University of Alabama at Birmingham | 105 | 2025-02-25 | 2025-12-22 |
| Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries Ketamine, Dexmedetomidine - Emergence Delirium | Phase 1 / Phase 2 | Unknown | Cairo University | 46 | 2024-08-10 | 2024-08-20 |
| Effects of Anesthetic Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries ketamine and dexmeditomidine combination, Propofol - Tethered Cord | Phase 1 | Completed | Cairo University | 46 | 2022-10-30 | 2024-02-07 |
| Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users HSK3486, Propofol, Placebo - General Anesthesia | Phase 1 | Completed | Haisco-USA Pharmaceuticals, Inc. | 42 | 2022-08-16 | 2023-10-13 |
| Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users HSK3486, propofol, Placebo - General Anesthesia | Phase 1 | Completed | Haisco-USA Pharmaceuticals, Inc. | 43 | 2022-08-16 | 2026-02-23 |
| Effect of Anesthetics on Troponin I and С-reactive Protein Propofol, Isoflurane, Sevoflurane - Mitral Valve Insufficiency, Aortic Valve Insufficiency | Phase 1 | Completed | Astana Medical University | 255 | 2021-11-30 | 2023-06-05 |
| A Study of Danavorexton in Anesthetized Adults Danavorexton, Danavorexton Placebo, Propofol - Healthy Volunteers | Phase 1 | Completed | Takeda | 28 | 2021-09-28 | 2022-05-10 |
| The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery Propofol, Isoflurane, Sevoflurane - Coronary Artery Disease, Mitral Valve Insufficiency | Phase 1 | Completed | Astana Medical University | 89 | 2021-01-22 | 2023-01-25 |
| Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I Propofol, Electroencephalography (EEG), Slow-Wave Activity - Treatment-resistant Depression | Phase 1 | Completed | Washington University School of Medicine | 16 | 2021-01-14 | 2026-04-23 |
| Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics Ketamine/ propofol, Dexmedetomidine - Vital Signs | Phase 1 | Completed | Ain Shams University | 40 | 2020-10-10 | 2022-08-05 |
| Memory & Conditioning Under Anesthesia Dexmedetomidine, Propofol, Fentanyl - Anesthesia, Pain | Phase 1 | Completed | Keith M Vogt | 92 | 2020-07-30 | 2025-04-18 |
| A Study to Evaluate the Differences in Pharmadynamics, Pharmacokinetics, and Safety Between Ciprofol and Propofol Ciprofol, Propofol - Anesthesia | Phase 1 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 18 | 2020-05-26 | 2020-11-20 |
| Comparison Between Two Drugs (Propofol and Nitroglycerin as a Hypotensive Agents During Endoscopic Sinus Surgery Propofol, Nitroglycerin - Hypotensive Anesthesia | Phase 1 / Phase 2 | Terminated | Ain Shams University | 40 | 2019-12-01 | 2020-02-17 |
| EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation IV Methylphenidate, Propofol - Anesthesia | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-11-01 | 2020-02-21 | |
| A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 HSK3486, Propofol - Anesthesia, Sedation | Phase 1 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 16 | 2019-01-09 | 2020-01-09 |
| Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery Lidocaine 1% Injectable Solution, Blood extraction, Sevoflurane - Colorectal Cancer | Phase 1 | Unknown | Iuliu Hatieganu University of Medicine and Pharmacy | 40 | 2018-11-26 | 2021-02-10 |
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Alzheimer Disease (2) · Aortic Valve Insufficiency (2) · Inflammation (2) · Mitral Valve Insufficiency (2) · Pain (2) · Sepsis (2) · Agnosia (1) · Amnesia (1) · Anxiety Disorders (1) · Atrial Fibrillation (1) · Brain Injuries (1) · Cancer Pain (1) · Chronobiology Disorders (1) · Cognitive Dysfunction (1) · Colorectal Neoplasms (1)
Ain Shams University (3) · Sichuan Haisco Pharmaceutical Group Co., Ltd (3) · Stanford University (3) · Astana Medical University (2) · Cairo University (2) · Eisai Inc. (2) · Haisco-USA Pharmaceuticals, Inc. (2) · Massachusetts General Hospital (2) · Southeast University, China (2) · University Clinical Centre of Kosova (2) · University Medical Centre Ljubljana (2) · Albert Einstein College of Medicine (1) · Asan Medical Center (1) · Beth Israel Deaconess Medical Center (1) · Carmelo Graffagnino (1)
United States (24) · China (5) · Egypt (5) · Kazakhstan (2) · Slovenia (2) · Sweden (2) · Albania (1) · Canada (1) · France (1) · Netherlands (1) · Romania (1) · Serbia (1) · South Korea (1) · Spain (1) · Taiwan (1)
Alibek Kh Mustafin, Professor (2) · Antigona Hasani, MD,MSC (2) · Iztok Potocnik, MD, MSC (2) · Jerry Ingrande, M.D., M.S. (2) · Alaa Ismail, MD (1) · Ales Jerin, PHD (1) · Anthony Doufas (1) · Ben Palanca, MD PhD (1) · Benno von Bormann, MD (1) · Blaz Karpe, PHD (1) · Brian O'Gara, MD (1) · Byung-Moon Choi, M.D. (1) · Carmelo Graffagnino, MD (1)
PMID 17621602, PMID 19417610, PMID 21399490, PMID 25559834, PMID 26056838, PMID 27001425, PMID 27079717, PMID 29181002, PMID 30260415, PMID 31151474, PMID 31455386, PMID 33079873, PMID 38296753
K23GM100273 (1), R34MH087390 (1), R35GM146822 (1), U01MH128483 (1)