53 completed, 11 unknown, 10 withdrawn, 4 not yet recruiting. 88 Phase 2, 18 Phase 3, 15 Phase 1.
Follow Propofol: new trials by email Literature Review of Propofol trials Research Report on Propofol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery Propofol (Astra-Zeneca), propofol and dexmetomidine - Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery | Phase 1 / Phase 2 | Not yet recruiting | Kafrelsheikh University | 60 | 2026-09-01 | 2026-09-01 |
| Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study Dexmedetomidine (+propofol as indicated), Ketamine - Healthy, Covert Consciousness | Phase 2 | Enrolling by invitation | University of Michigan | 60 | 2026-08-07 | 2026-08-11 |
| Study of Psilocybin Under Anesthesia Controlled by EEG Psilocybin (Usona Institute), Propofol, Placebo - Major Depression | Phase 2 | Not yet recruiting | Stanford University | 10 | 2026-07-01 | 2026-05-06 |
| Sevoflurane Sedation in Patients With Septic Shock Sevoflurane, Control Group - Shock, Septic | Phase 2 | Not yet recruiting | University of Zurich | 153 | 2026-01-01 | 2025-04-01 |
| The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy Remimazolam, Propofol - Remimazolam Besylate, Thoracoscopic Lobectomy | Phase 1 / Phase 2 | Not yet recruiting | Jinqiao Qian | 150 | 2025-08-01 | 2025-07-25 |
| Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder Propofol - PTSD, Post-traumatic Stress Disorder | Phase 2 | Recruiting | Stanford University | 42 | 2025-07-21 | 2026-10-02 |
| A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients Remimazolam Tosilate for injection, Propofol Injection - Operative Sedation of Pediatric, Operative Sedation of Adolescent Patients | Phase 2 / Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 249 | 2025-07-10 | 2026-06-04 |
| Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II Propofol, Electroencephalography (EEG), Brief Behavioral Therapy for Insomnia - Depression | Phase 2 | Recruiting | Washington University School of Medicine | 70 | 2025-03-04 | 2026-08-27 |
| Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest esketamine hydrochloride, propofol - Out-of-hospital Cardiac Arrest (OHCA) | Phase 2 | Recruiting | Christian Hassager | 282 | 2024-12-12 | 2024-12-20 |
| Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries Ketamine, Dexmedetomidine - Emergence Delirium | Phase 1 / Phase 2 | Unknown | Cairo University | 46 | 2024-08-10 | 2024-08-20 |
| Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion Hybrid anesthesia (propofol + sevoflurane), Propofol only TIVA - Post-operative Nausea and Vomiting | Phase 2 | Completed | Milton S. Hershey Medical Center | 65 | 2024-02-01 | 2026-08-14 |
| Magnesium Sulfate as an Adjuvant to Propofol During Consious Sedation in Colonoscopy Magnesium Sulfate, Propofol - Magnesium, Intraoperative Analgesia | Phase 2 / Phase 3 | Unknown | Assiut University | 60 | 2024-01-01 | 2023-12-18 |
| Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation Propofol injection and fentanyl, Bupivacain - Perioperative Pain | Phase 2 | Completed | Benha University | 42 | 2023-11-15 | 2026-02-06 |
| Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome Propofol, Isoflurane - Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication | Phase 2 / Phase 3 | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 20 | 2023-11-01 | 2026-06-04 |
| Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients Fospropofol disodium for injection, Propofol - Critical Illness | Phase 2 | Unknown | Xiaobo Yang, MD | 60 | 2023-06-01 | 2023-07-05 |
| Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study Biospecimen Collection, Electronic Health Record Review, Fentanyl Citrate - Colon Adenocarcinoma | Phase 2 | Unknown | University of Kansas Medical Center | 80 | 2023-05-22 | 2023-08-30 |
| Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage Ketamine Hydrochloride, Propofol - Subarachnoid Hemorrhage, Aneurysmal | Phase 2 / Phase 3 | Withdrawn | Jenna L Leclerc MD, PhD | 2023-04-27 | 2023-05-01 | |
| Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation Remimazolam Besylate, Propofol - Critically Ill, Deep Sedation | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2022-09-05 | 2022-09-26 |
| Ultrasonic Deep Brain Stimulation During Anesthetic Sedation Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI) using Propofol - Mental Function | Phase 2 | Completed | University of Michigan | 13 | 2022-08-26 | 2025-03-12 |
| Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients Fospropofol disodium for injection, Propofol - Critical Illness | Phase 2 | Completed | Xiaobo Yang, MD | 60 | 2022-08-10 | 2023-09-21 |
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Critical Illness (4) · Depressive Disorder, Treatment-Resistant (2) · Hematoma, Subdural, Chronic (2) · Intraoperative Awareness (2) · Pain, Postoperative (2) · Sepsis (2) · Shock, Septic (2) · Subarachnoid Hemorrhage (2) · Acute Kidney Injury (1) · Airway Remodeling (1) · Atrial Fibrillation (1) · Brain Edema (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Breast Neoplasms (1)
Assiut University (4) · Jiangsu HengRui Medicine Co., Ltd. (4) · Sichuan Haisco Pharmaceutical Group Co., Ltd (4) · Cairo University (2) · Kasr El Aini Hospital (2) · Massachusetts General Hospital (2) · Menoufia University (2) · Milton S. Hershey Medical Center (2) · Stanford University (2) · Universitaire Ziekenhuizen KU Leuven (2) · University Clinical Centre of Kosova (2) · University of British Columbia (2) · University of Michigan (2) · University of Utah (2) · University of Zurich (2)
United States (23) · China (16) · Egypt (11) · Canada (3) · Switzerland (3) · Belgium (2) · Iran (2) · Taiwan (2) · Albania (1) · Brazil (1) · Croatia (1) · Denmark (1) · Germany (1) · Greece (1) · India (1)
Abd-Elazeem A Elbakry, MD (2) · Antigona Hasani, MD,MSC (2) · Arlyne Thung, MD (1) · Athina Siampalioth, MD (1) · Ben Palanca, MD PhD (1) · Benno von Bormann, MD (1) · Boris D Heifets, MD, PhD (1) · Brian J Mickey, MD, PhD (1) · Brian O'Gara, MD (1) · Carmelo Graffagnino, MD (1) · DaiWai M Olson, PhD RN (1) · David DY Chen, Ph.D (1) · David M. Ansley, MD (1) · David Sheridan, MD (1)
PMID 15460178, PMID 16278131, PMID 19607937, PMID 19923528, PMID 21926576, PMID 24247230, PMID 24893689, PMID 25794212, PMID 26056838, PMID 26709032, PMID 26721648, PMID 27597733, PMID 28598913, PMID 30232735, PMID 31151474, PMID 32616309, PMID 36680620, PMID 40204440, PMID 40211146, PMID 41259542, PMID 41593496, PMID 41870554
R01GM103894 (2), P30CA168524 (1), R21DK089369 (1), U01MH128483 (1)