28 completed, 4 terminated, 4 unknown, 4 withdrawn. 13 Phase 4, 10 Not applicable, 10 Phase 2, 9 Phase 3, 2 Phase 1.
Follow Prometrium: new trials by email Literature Review of Prometrium trials Research Report on Prometrium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS) Micronized progesterone (oral capsules), placebo capsule - Healthy Volunteers, Female | Phase 1 | Completed | McMaster University | 20 | 2026-01-01 | 2026-06-17 |
| Estrogen Supplementation and Bone Health in Women With CF Transdermal estrogen, Progesterone - Cystic Fibrosis, Hypoestrogenism | Phase 4 | Recruiting | Johns Hopkins University | 75 | 2023-05-02 | 2025-11-14 |
| Estrogen Variability and Irritability During the Menopause Transition Estradiol Patch, 0.1 mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo, Progesterone 200 mg - Menopause, Irritable Mood | Phase 4 | Completed | University of North Carolina, Chapel Hill | 40 | 2022-06-15 | 2025-11-26 |
| HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss Progesterone Pill, hCG - Recurrent Pregnancy Loss Without Current Pregnancy | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2022-05-01 | 2022-05-09 | |
| Examining the Effects of Estradiol on Neural and Molecular Response to Reward Transdermal Estradiol, Micronized Progesterone, Matching Placebo Patch - Depression, Psychosis | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 103 | 2022-04-20 | 2026-04-29 |
| Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone 200mg, Inactive Clear Patch - Suicidal Ideation | Phase 4 | Completed | University of Illinois at Chicago | 124 | 2020-09-15 | 2025-12-19 |
| Neurobiology of Bulimia Nervosa Estradiol, Micronized progesterone, Leuprolide Acetate - Bulimia Nervosa | Phase 2 | Completed | University of North Carolina, Chapel Hill | 10 | 2020-02-24 | 2022-07-26 |
| Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone - Perinatal Depression, Post Partum Depression | Phase 2 | Completed | University of North Carolina, Chapel Hill | 23 | 2020-01-02 | 2023-08-25 |
| Blocking Mifepristone Action With Progesterone Mifepristone 200 MG, micronized Progesterone, Placebo oral capsule - Pregnancy, Unwanted | Phase 1 / Phase 2 | Terminated | University of California, Davis | 12 | 2019-02-11 | 2020-01-22 |
| Impact of Progesterone on Stress Reactivity and Cannabis Use Progesterone, Placebo - Cannabis Use | Phase 2 | Completed | Medical University of South Carolina | 148 | 2019-01-18 | 2023-09-28 |
| Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality Transdermal Estradiol + Placebo, Oral Micronized Progesterone + Placebo, Placebos - Suicidal Ideation | Phase 4 | Completed | University of Illinois at Chicago | 60 | 2018-07-27 | 2022-09-14 |
| Canadian Study on the Association of Pessary With Progesterone Prometrium, Dr. Arabin, cerclage pessary perforated - Preterm Birth, Short Cervix | Not applicable | Completed | Université de Sherbrooke | 79 | 2018-06-04 | 2023-04-06 |
| Progesterone Supplementation in Frozen Embryo Transfer Cycles Prometrium - Infertility Due to Nonimplantation, Infertility | Not applicable | Unknown | Mount Sinai Hospital, Canada | 240 | 2018-05-01 | 2018-04-20 |
| Progesterone for Cannabis Withdrawal Progesterone, Placebo - Cannabis Use Disorder, Cannabis Withdrawal | Early Phase 1 | Completed | Medical University of South Carolina | 8 | 2017-10-16 | 2019-05-22 |
| Cerclage for Twins With Short Cervix Cervical Cerclage placement, Vaginal Progesterone - Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2 | Phase 2 / Phase 3 | Withdrawn | Pediatrix | 2017-10-01 | 2018-03-21 | |
| The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood Estradiol Patch, 0.1 Mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo Patch, Progesterone Capsule - Perimenopausal Disorder, Stress, Emotional | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 82 | 2017-01-24 | 2021-03-26 |
| Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women 17beta Estradiol, Transdermal placebo patch, Progesterone - Estrogen Deficiency, Cardiovascular Disease (CVD) | Phase 2 | Completed | Cedars-Sinai Medical Center | 29 | 2017-01-01 | 2025-03-13 |
| Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone, Inactive Clear Patch - Suicidal Ideation | Phase 4 | Completed | University of North Carolina, Chapel Hill | 30 | 2016-12-31 | 2019-02-04 |
| Patients' Preference for Subcutaneous or Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles Progesterone 25 MG subcutaneous, Micronized progesterone 200 MG, recombinant FSH - Infertility, In Vitro Fertilization | Phase 4 | Terminated | Andros Day Surgery Clinic | 60 | 2016-12-20 | 2020-01-10 |
| Progesterone Augmentation of Nicotine Replacement Therapy Study Progesterone (200 mgs BID), Placebo - Smoking Cessation | Phase 4 | Completed | Yale University | 64 | 2016-04-07 | 2019-07-23 |
Showing 20 of 42. Sign in to see all of them.
Depression (6) · Amenorrhea (3) · Bone Diseases, Metabolic (3) · Infertility (3) · Mood Disorders (3) · Premature Birth (3) · Suicidal Ideation (3) · Cardiovascular Diseases (2) · Cocaine-Related Disorders (2) · Depressive Disorder (2) · Hot Flashes (2) · Mental Disorders (2) · Osteoporosis (2) · Primary Ovarian Insufficiency (2) · Suicide (2)
University of North Carolina, Chapel Hill (7) · University of Minnesota (3) · University of Pennsylvania (3) · Yale University (3) · Massachusetts General Hospital (2) · Medical University of South Carolina (2) · Mount Sinai Hospital, Canada (2) · University of Illinois at Chicago (2) · Wake Forest University Health Sciences (2) · Andros Day Surgery Clinic (1) · Ben-Gurion University of the Negev (1) · Cedars-Sinai Medical Center (1) · Intira Sriprasert (1) · Johns Hopkins University (1) · Kronos Longevity Research Institute (1)
United States (32) · Canada (4) · Israel (1) · Italy (1)
Susan Girdler, PhD (3) · Crystal E Schiller, PhD (2) · Tory A Eisenlohr-Moul, PhD (2) · Adolfo Allegra, MD (1) · Andrew Combs, MD (1) · Brian J Sherman, PhD (1) · Chrisandra Shufelt, MD (1) · Christopher M Miles, MD (1) · Crystal Schiller, PhD (1) · Cynthia N Epperson, M.D. (1) · Cynthia N Epperson, MD (1) · Darrell M Wilson (1) · David F Archer, MD (1) · Dennis M Black, PhD (1) · E Kirk Neely (1)
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K12HD001441 (1), K23HL077179 (1), K23MH105569 (1), K24DA030301 (1), K24DA038240 (1), K99MH109667 (1), P50DA033942 (1), R00MH109667 (1), R01DA014573 (1), R01HD060827 (1), R01HL071159 (1), R01MH108690 (1), R01MH128238 (1), R21CA198187 (1), R21DA029914 (1)