5 completed, 3 withdrawn, 1 unknown. 9 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 5, Withdrawn 3, Unknown 1 |
| Phase 2 | 2 | Unknown 1, Withdrawn 1 |
Follow Prometrium: new trials by email Literature Review of Prometrium trials Research Report on Prometrium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cerclage for Twins With Short Cervix Cervical Cerclage placement, Vaginal Progesterone - Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2 | Phase 2 / Phase 3 | Withdrawn | Pediatrix | 2017-10-01 | 2018-03-21 | |
| Hormone Replacement for Premature Ovarian Insufficiency Hormone Replacement Therapy, Combined Oral Contraceptives - Primary Ovarian Insufficiency | Phase 3 | Withdrawn | University of Pennsylvania | 2016-03-01 | 2019-07-05 | |
| Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women oral estradiol 1.0 mg, oral progesterone 100 mg - Menopause | Phase 3 | Completed | Intira Sriprasert | 20 | 2015-12-01 | 2020-03-19 |
| A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix Vaginal progesterone, Placebo, Arabin Pessary - Short Cervical Length | Phase 3 | Completed | The George Washington University Biostatistics Center | 1311 | 2015-11-13 | 2026-06-25 |
| A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms Estradiol, Progesterone, Placebo - Menopause | Phase 3 | Completed | TherapeuticsMD | 1845 | 2013-08-05 | 2019-05-06 |
| Progesterone for Perimenopausal Night Sweats Oral micronized progesterone, placebo - Hot Flushes, Night Sweats | Phase 3 | Completed | University of British Columbia | 249 | 2011-10-01 | 2019-12-16 |
| PP13 and Doppler Study to Predict Preeclampsia Progesterone, Low molecular weight Heparin, No Drug - Preeclampsia | Phase 2 / Phase 3 | Unknown | Ben-Gurion University of the Negev | 1000 | 2009-08-01 | 2009-06-25 |
| Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes Transdermal 17Beta-estradiol, progesterone, Ethinyl Estradiol + Desogestrel, Sham Comparator - Exercise-related Amenorrhea | Phase 3 | Completed | Massachusetts General Hospital | 121 | 2009-05-01 | 2021-06-11 |
| Bone Mass Accrual in Adolescent Athletes Estrogen - Amenorrhea, Bone Loss | Phase 3 | Withdrawn | Massachusetts General Hospital | 2008-12-01 | 2021-10-26 |
Amenorrhea (2) · Bone Diseases, Metabolic (2) · Hot Flashes (2) · Premature Birth (2) · Anxiety Disorders (1) · Depression (1) · Osteoporosis (1) · Parasomnias (1) · Pre-Eclampsia (1) · Primary Ovarian Insufficiency (1) · Uterine Cervical Incompetence (1)
Massachusetts General Hospital (2) · Ben-Gurion University of the Negev (1) · Intira Sriprasert (1) · Pediatrix (1) · The George Washington University Biostatistics Center (1) · TherapeuticsMD (1) · University of British Columbia (1) · University of Pennsylvania (1)
United States (6) · Canada (1) · Israel (1)
Andrew Combs, MD (1) · David F Archer, MD (1) · Jerilynn C Prior, MD, FRCPC (1) · Joseph Biggio, MD (1) · Madhu Misra, MD, MPH (1) · Madhusmita Misra, MD, MPH (1) · Monica Longo, MD (1) · Reli Hershkovitz, MD (1) · Sebastian Mirkin, MD (1)
PMID 21816790, PMID 22252944, PMID 25835751, PMID 28297591, PMID 29889748, PMID 30301734, PMID 30476179, PMID 30586005, PMID 30601452, PMID 30639922, PMID 31364889, PMID 31603998, PMID 31913228, PMID 32740481, PMID 32932401, PMID 33110039, PMID 35213517
R01HD060827 (1), U24HD036801 (1), UG1HD027869 (1), UG1HD027915 (1), UG1HD034208 (1), UG1HD040485 (1), UG1HD040500 (1), UG1HD040512 (1), UG1HD040544 (1), UG1HD040545 (1), UG1HD040560 (1), UG1HD053097 (1), UG1HD068258 (1), UG1HD068268 (1), UG1HD068282 (1)