8 completed, 2 recruiting, 2 terminated, 1 unknown. 13 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Completed 8, Recruiting 2, Terminated 2, Unknown 1 |
Follow Prometrium: new trials by email Literature Review of Prometrium trials Research Report on Prometrium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Estrogen Supplementation and Bone Health in Women With CF Transdermal estrogen, Progesterone - Cystic Fibrosis, Hypoestrogenism | Phase 4 | Recruiting | Johns Hopkins University | 75 | 2023-05-02 | 2025-11-14 |
| Estrogen Variability and Irritability During the Menopause Transition Estradiol Patch, 0.1 mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo, Progesterone 200 mg - Menopause, Irritable Mood | Phase 4 | Completed | University of North Carolina, Chapel Hill | 40 | 2022-06-15 | 2025-11-26 |
| Examining the Effects of Estradiol on Neural and Molecular Response to Reward Transdermal Estradiol, Micronized Progesterone, Matching Placebo Patch - Depression, Psychosis | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 103 | 2022-04-20 | 2026-04-29 |
| Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone 200mg, Inactive Clear Patch - Suicidal Ideation | Phase 4 | Completed | University of Illinois at Chicago | 124 | 2020-09-15 | 2025-12-19 |
| Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality Transdermal Estradiol + Placebo, Oral Micronized Progesterone + Placebo, Placebos - Suicidal Ideation | Phase 4 | Completed | University of Illinois at Chicago | 60 | 2018-07-27 | 2022-09-14 |
| The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood Estradiol Patch, 0.1 Mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo Patch, Progesterone Capsule - Perimenopausal Disorder, Stress, Emotional | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 82 | 2017-01-24 | 2021-03-26 |
| Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone, Inactive Clear Patch - Suicidal Ideation | Phase 4 | Completed | University of North Carolina, Chapel Hill | 30 | 2016-12-31 | 2019-02-04 |
| Patients' Preference for Subcutaneous or Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles Progesterone 25 MG subcutaneous, Micronized progesterone 200 MG, recombinant FSH - Infertility, In Vitro Fertilization | Phase 4 | Terminated | Andros Day Surgery Clinic | 60 | 2016-12-20 | 2020-01-10 |
| Progesterone Augmentation of Nicotine Replacement Therapy Study Progesterone (200 mgs BID), Placebo - Smoking Cessation | Phase 4 | Completed | Yale University | 64 | 2016-04-07 | 2019-07-23 |
| Perimenopausal Effects of Estradiol on Reward Responsiveness Estradiol, Progesterone - Perimenopausal Depression | Phase 4 | Completed | University of North Carolina, Chapel Hill | 64 | 2015-10-01 | 2019-11-12 |
| Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Progesterone, Placebo - Concussion | Phase 4 | Completed | Wake Forest University Health Sciences | 25 | 2013-06-01 | 2018-08-28 |
| Progesterone and Brain Imaging Study Progesterone, Placebo - Nicotine Dependence, Nicotine Withdrawal | Phase 4 | Completed | University of Pennsylvania | 81 | 2010-11-01 | 2022-07-05 |
| Kronos Early Estrogen Prevention Study (KEEPS) Conjugated equine estrogens 0.45 mg/day, Transdermal estradiol, 50 mcg/day, Micronized progesterone, 200 mg/day x 12 d/month - Menopause, Arteriosclerosis | Phase 4 | Unknown | Kronos Longevity Research Institute | 728 | 2005-09-01 | 2009-09-14 |
Depression (4) · Suicidal Ideation (3) · Depressive Disorder (2) · Mood Disorders (2) · Suicide (2) · Anhedonia (1) · Arteriosclerosis (1) · Bone Diseases (1) · Bone Diseases, Metabolic (1) · Brain Concussion (1) · Coronary Disease (1) · Cystic Fibrosis (1) · Infertility (1) · Mental Disorders (1) · Osteoporosis (1)
University of North Carolina, Chapel Hill (5) · University of Illinois at Chicago (2) · Andros Day Surgery Clinic (1) · Johns Hopkins University (1) · Kronos Longevity Research Institute (1) · University of Pennsylvania (1) · Wake Forest University Health Sciences (1) · Yale University (1)
United States (12) · Italy (1)
Susan Girdler, PhD (3) · Tory A Eisenlohr-Moul, PhD (2) · Adolfo Allegra, MD (1) · Christopher M Miles, MD (1) · Crystal E Schiller, PhD (1) · Crystal Schiller, PhD (1) · Cynthia N Epperson, M.D. (1) · Dennis M Black, PhD (1) · Elizabeth Andersen, PhD (1) · Frederick Naftolin, MD, PhD (1) · Gabriel Dichter, PhD (1) · Howard Hodis, MD (1) · John A Lucas, MD (1) · Kimberly Yonkers, MD (1) · Malinda Wu, MD, MSc (1)
PMID 19657788, PMID 19996872, PMID 22209479, PMID 22587616, PMID 23312232, PMID 23322818, PMID 23670850, PMID 23874743, PMID 25069991, PMID 26035291, PMID 27393520, PMID 28364870, PMID 28846767, PMID 31078511, PMID 31652073, PMID 32015261, PMID 32520900, PMID 35713950, PMID 35809362, PMID 36274158, PMID 36395695, PMID 36585408, PMID 36855177, PMID 37326562, PMID 37611527, PMID 39729067, PMID 41618732, PMID 41913970
K12HD001441 (1), K23MH105569 (1), K24DA030301 (1), K99MH109667 (1), R00MH109667 (1), R01MH108690 (1), R01MH128238 (1), R21CA198187 (1), R21MH128241 (1)