11 completed, 4 recruiting, 3 not yet recruiting, 1 suspended. 21 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Completed 11, Recruiting 4, Not yet recruiting 3, Suspended 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial Pregnenolone, DHEA, Placebo - Chronic Low Back Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 108 | 2026-12-01 | 2026-09-08 |
| Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder Pregnenolone, Placebo - Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | Phase 2 | Not yet recruiting | Sherwood Brown, MD, PhD | 100 | 2026-10-01 | 2026-08-24 |
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
| Pregnenolone as a Treatment for Cannabis Intoxication Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg - Cannabis Intoxication | Phase 2 | Recruiting | Johns Hopkins University | 20 | 2026-04-24 | 2026-09-29 |
| A New Intervention to Improve Function in Veterans With Anxiety and Depression Pregnenolone, Placebo - Anxiety and Depression | Phase 2 | Recruiting | VA Office of Research and Development | 84 | 2025-08-14 | 2026-10-14 |
| Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans Pregnenolone, Placebo - Traumatic Brain Injury, TBI | Phase 2 | Suspended | Christine Marx, MD | 108 | 2024-09-06 | 2026-05-13 |
| Pregnenolone for the Treatment of Alcohol Use Disorder Pregnenolone, Placebo - Alcohol Use Disorder | Phase 2 | Recruiting | Yale University | 150 | 2024-01-08 | 2026-02-02 |
| Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV Placebo, Pregnenolone - Major Depressive Disorder, Anxiety Depression | Phase 2 | Recruiting | Massachusetts General Hospital | 120 | 2023-03-03 | 2025-09-12 |
| Neurosteroids for Treatment of PTSD in Veterans Pregnenolone, Placebo - Posttraumatic Stress Disorder | Phase 2 | Completed | VA Office of Research and Development | 97 | 2019-06-27 | 2026-08-26 |
| A Neurosteroid Intervention for Menopausal and Perimenopausal Depression Pregnenolone, Placebo - Major Depressive Disorder, Menopause | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 73 | 2018-09-01 | 2026-01-22 |
| Effects of Pregnenolone on Perceived Social Isolation Pregnenolone 175mg, Pregnenolone 400mg, Placebo - Perceived Social Isolation | Phase 2 | Terminated | University of Chicago | 34 | 2017-05-01 | 2024-05-16 |
| Pilot Trial of Pregnenolone in Autism Pregnenolone, Placebo - Autism Spectrum Disorder, Autism | Phase 2 | Completed | Stanford University | 40 | 2016-01-29 | 2026-03-30 |
| Pregnenolone and Marijuana Dependence Pregnenolone, Placebo - Marijuana Dependence | Phase 2 | Completed | Medical University of South Carolina | 21 | 2015-06-01 | 2018-06-18 |
| Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI) Pregnenolone, Placebo - Fatigue, Musculoskeletal Pain | Phase 2 | Completed | VA Office of Research and Development | 170 | 2013-10-01 | 2020-05-01 |
| Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans Pregnenolone, Placebo - Brain Injuries, Traumatic | Phase 2 | Completed | VA Office of Research and Development | 53 | 2013-10-01 | 2019-07-12 |
| Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans Pregnenolone, Placebo - Lower Back Pain | Phase 2 | Completed | Durham VA Medical Center | 94 | 2013-09-13 | 2018-10-03 |
| A Study of Pregnenolone in the Treatment of Individuals With Autism Pregnenolone - Autistic Disorder | Phase 2 | Completed | Stanford University | 15 | 2011-07-01 | 2017-03-29 |
| Adjunctive Pregnenolone in Post-Traumatic Stress Disorder (PTSD) and Depression in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans pregnenolone, placebo - Post-traumatic Stress Disorder, Major Depressive Disorder | Phase 2 | Withdrawn | US Department of Veterans Affairs | 2010-01-01 | 2014-10-27 | |
| The Effects of One-Time Pregnenolone, Dehydroepiandrosterone (DHEA), or Placebo Administration On Withdrawal Symptoms, Mood, Craving And Cigarette Evaluation Ratings In Male Smokers dehydroepiandrosterone (DHEA), pregnenolone, Placebo - Substance Withdrawal Syndrome | Phase 2 | Completed | Jed E. Rose | 22 | 2009-07-01 | 2012-09-21 |
| Study of a Neurocognition Enhancing Agent in Patients With Schizophrenia Pregnenolone, Placebo - Schizophrenia | Phase 2 / Phase 3 | Completed | National Research Foundation, Singapore | 120 | 2009-06-01 | 2011-10-06 |
Showing 20 of 21. Sign in to see all of them.
Depression (5) · Depressive Disorder, Major (5) · Pain (4) · Alcoholism (2) · Anxiety Disorders (2) · Autistic Disorder (2) · Brain Injuries, Traumatic (2) · Marijuana Abuse (2) · Schizophrenia (2) · Stress Disorders, Post-Traumatic (2) · Autism Spectrum Disorder (1) · Cognitive Dysfunction (1) · Fatigue (1) · Low Back Pain (1) · Musculoskeletal Pain (1)
VA Office of Research and Development (5) · Stanford University (2) · University of Texas Southwestern Medical Center (2) · Christine Marx, MD (1) · Durham VA Medical Center (1) · Jed E. Rose (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Medical University of South Carolina (1) · National Research Foundation, Singapore (1) · Sherwood Brown, MD, PhD (1) · US Department of Veterans Affairs (1) · University of Chicago (1) · Weill Medical College of Cornell University (1) · Yale University (1)
United States (20) · Singapore (1)
Christine E. Marx, MD MA (3) · Jennifer C Naylor, PhD (3) · Aimee McRae-Clark, PharmD (1) · Antonio Hardan, MD (1) · Antonio Y. Hardan, MD (1) · Chris Marx, MD (1) · Christine E Marx, MD (1) · Christine Marx, M.D. (1) · Christine Marx, MD MA (1) · David Wolinsky, MD (1) · E. Sherwood Brown (1) · Jason J Kim, MD (1) · Jed E Rose, Ph.D. (1) · Jennifer C. Naylor, PhD (1) · Marlene Freeman, MD (1)
1IK2RX000908-01A1 (1), 1UG3DA066242-01 (1), I01CX001784 (1), I01CX002667 (1), I01RX004287 (1), R01AA030923 (1), R01AA033156 (1), R01MH131194 (1), R21DA063854 (1)