3 completed, 1 not yet recruiting, 1 unknown, 1 withdrawn. 6 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 3, Not yet recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
Follow Pregnenolone: new trials by email Literature Review of Pregnenolone trials Research Report on Pregnenolone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
| Feasibility Trial of Pregnenolone for Posttraumatic Stress Disorder and Alcohol Use Disorder Pregnenolone 250 mg, Pregnenolone 400 mg - Post Traumatic Stress Disorder, Alcohol Use Disorder | Phase 1 | Withdrawn | University of Texas Southwestern Medical Center | 2021-12-01 | 2021-08-23 | |
| Development of Pregnenolone as a Treatment for Depression Pregnenolone 500 mg, Pregnenolone 800 mg, Placebo - Major Depressive Disorder | Phase 1 | Completed | University of Texas Southwestern Medical Center | 34 | 2019-09-01 | 2024-05-01 |
| A Neurosteroid Intervention for Menopausal and Perimenopausal Depression Pregnenolone, Placebo - Major Depressive Disorder, Menopause | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 73 | 2018-09-01 | 2026-01-22 |
| Pregnenolone in the Management of Schizophrenia Patients Pregnenolone - Schizophrenia | Phase 1 | Completed | Sha'ar Menashe Mental Health Center | 60 | 2005-01-01 | 2008-05-21 |
| Neurosteroids and Acute Alcohol Intoxication in Humans Pregnenolone - Alcohol Intoxication | Phase 1 | Unknown | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 92 | 2004-05-01 | 2008-12-19 |
Depressive Disorder, Major (3) · Depression (2) · Alcoholic Intoxication (1) · Alcoholism (1) · Schizophrenia (1) · Stress Disorders, Post-Traumatic (1)
University of Texas Southwestern Medical Center (4) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · Sha'ar Menashe Mental Health Center (1)
United States (4) · Israel (1)
Sherwood Brown, MD, PhD (2) · E. Sherwood Brown (1) · E. Sherwood Brown, MD, PhD, MBA (1) · Marlene Freeman, MD (1) · Michael S. Ritsner, MD, PhD (1)
1UG3DA066242-01 (1), R61AT009625 (1)