27 completed, 11 terminated, 8 recruiting, 3 unknown. 53 Phase 2, 14 Phase 3, 8 Phase 1.
Follow Oxygen: new trials by email Literature Review of Oxygen trials Research Report on Oxygen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study Oxygen Gas for Inhalation, Standard of care - Inflammatory Bowel Disease (IBD), Crohn Disease | Phase 1 / Phase 2 | Not yet recruiting | University of British Columbia | 54 | 2026-09-01 | 2026-08-26 |
| A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia Oxygen, Room air - Pulmonary Hypertension | Phase 1 / Phase 2 | Withdrawn | Duke University | 2026-07-01 | 2026-09-03 | |
| Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy Ozone therapy, Oxygen (placebo) - Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia | Phase 2 / Phase 3 | Recruiting | Bernardino Clavo, MD, PhD | 42 | 2025-02-07 | 2026-09-18 |
| Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544). Ozone therapy, Oxygen (placebo) - Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia | Phase 2 / Phase 3 | Recruiting | Bernardino Clavo, MD, PhD | 42 | 2025-02-07 | 2026-09-25 |
| Nitrous Oxide in the Treatment of Acute Suicidal Ideation 50% N2O plus 50% O2, Oxygen (O2) - Suicidality, EEG | Phase 2 | Recruiting | University of Zurich | 85 | 2025-01-13 | 2025-01-16 |
| Oxygen as an Acute Treatment in Alternating Hemiplegia of Childhood Oxygen, Placebo - Alternating Hemiplegia of Childhood | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 24 | 2024-09-16 | 2026-04-13 |
| Oxygen Targets in Acute Heart Failure With Pulmonary Congestion Oxygen - Acute Heart Failure, Pulmonary Congestion | Phase 2 / Phase 3 | Completed | Copenhagen University Hospital, Hvidovre | 135 | 2024-02-01 | 2026-10-26 |
| 129Xe MRI Cardiopulmonary Hyperpolarized Xe129, Oxygen Administration - Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Recruiting | Bastiaan Driehuys | 125 | 2024-01-12 | 2026-02-04 |
| Down Syndrome Obstructive Sleep Apnea Oxygen - Down Syndrome, Obstructive Sleep Apnea | Phase 2 | Recruiting | Brigham and Women's Hospital | 230 | 2023-10-24 | 2026-09-30 |
| Nitrous Oxide for PTSD Nitrous Oxide, Midazolam, Nitrogen - PTSD | Phase 2 | Terminated | VA Office of Research and Development | 1 | 2021-10-07 | 2023-03-03 |
| Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women Nitrous oxide gas for inhalation, Oxygen Gas for Inhalation - Contraceptive Devices, Long-Acting Reversible Contraception | Phase 2 / Phase 3 | Withdrawn | Boston Children's Hospital | 2021-06-01 | 2022-09-16 | |
| Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients Oxygen - Covid19 | Phase 2 / Phase 3 | Unknown | Ottawa Hospital Research Institute | 234 | 2021-04-15 | 2021-11-01 |
| Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ) Ozone, Oxygen - Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic | Phase 2 / Phase 3 | Recruiting | Bernardino Clavo, MD, PhD | 42 | 2020-11-30 | 2026-09-25 |
| Ozone Therapy in Refractory Ischemic Heart Disease. Ozone, Oxygen - Ischemic Heart Disease | Phase 2 / Phase 3 | Terminated | Bernardino Clavo, MD, PhD | 1 | 2020-02-26 | 2022-04-04 |
| Protective Effect of Aspirin on COVID-19 Patients Aspirin 100mg - Novel Coronavirus Pneumonia, Aspirin | Phase 2 / Phase 3 | Unknown | Xijing Hospital | 128 | 2020-02-10 | 2020-04-28 |
| Blend to Limit Oxygen in ECMO: A Randomised Controlled Registry Trial Oxygen - Cardiac Failure, Critical Illness | Phase 2 | Completed | Australian and New Zealand Intensive Care Research Centre | 300 | 2019-09-18 | 2024-08-09 |
| Feasibility of FMISO in Brain Tumors ¹⁸F-Fluoromisonidazole, Computed Tomography, Magnetic Resonance Imaging - IDH Wild Type Glioblastoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 77 | 2019-06-01 | 2026-09-18 |
| Sleep Disordered Breathing With Opioid Use Hyperoxia, Acetazolamide - Sleep Apnea, Opioid Use | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 150 | 2019-05-02 | 2026-07-01 |
| The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia Oxygen - Oxygen Deficiency, Pulmonary Arterial Hypertension | Phase 2 | Completed | Heidelberg University | 20 | 2019-04-01 | 2024-06-20 |
| Maternal Hyperoxygenation in Congenital Heart Disease Maternal Hyperoxygenation - Hypoplastic Left Heart Syndrome | Phase 1 / Phase 2 | Completed | The Hospital for Sick Children | 25 | 2018-02-02 | 2024-03-26 |
Showing 20 of 53. Sign in to see all of them.
Sleep Apnea, Obstructive (4) · Depression (3) · Heart Failure (3) · Hypoxia (3) · Anxiety Disorders (2) · Asthma (2) · Dyspnea (2) · Hyperoxia (2) · Hypesthesia (2) · Neuralgia (2) · Paresthesia (2) · Pulmonary Disease, Chronic Obstructive (2) · Pulmonary Fibrosis (2) · Sleep Apnea Syndromes (2) · Acidosis, Respiratory (1)
Bernardino Clavo, MD, PhD (4) · Brigham and Women's Hospital (4) · Boston Children's Hospital (2) · Duke University (2) · University of Chicago (2) · VA Office of Research and Development (2) · Air Liquide SA (1) · Air Liquide Santé International (1) · Aria Aesthetics Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Australian and New Zealand Intensive Care Research Centre (1) · Barry Miskin, MD (1) · Bastiaan Driehuys (1) · Charite University, Berlin, Germany (1) · Children's Hospital Medical Center, Cincinnati (1)
United States (25) · Spain (5) · Canada (4) · Germany (4) · Australia (3) · France (3) · Brazil (2) · China (1) · Denmark (1) · Reunion (1) · Saint Kitts and Nevis (1) · Sweden (1) · Switzerland (1) · Thailand (1) · United Kingdom (1)
Bernardino Clavo, MD, PhD (4) · Pedro G Serrano-Aguilar, MD, PhD (2) · Andrew Clark (1) · Aneesh B Singhal, MD (1) · Arlyne Thung, MD (1) · Atul Malhotra, MD (1) · Barry Miskin, MD (1) · Benno von Bormann, MD (1) · Bernardino Clavo, MD (1) · Bradley A Edwards, PhD (1) · Cai Yue (1) · Carolyn I Rodriguez, MD PhD (1) · Celestina Amador, MD, PhD (1) · Daniel Edmonston, MD, MHS (1)
PMID 19151054, PMID 19183804, PMID 19260079, PMID 21427067, PMID 21575276, PMID 23102757, PMID 23549581, PMID 24687190, PMID 24733808, PMID 25699252, PMID 26056838, PMID 26296299, PMID 27206964, PMID 28329240, PMID 28454823, PMID 28651648, PMID 29100885, PMID 29610659, PMID 29684433, PMID 30633959, PMID 31779159, PMID 32379556, PMID 33044394, PMID 33289280, PMID 33738491, PMID 34914658, PMID 35050957, PMID 36060678, PMID 37489818, PMID 37876374, PMID 38629477, PMID 39110454, PMID 39162827, PMID 39688178, PMID 39705180, PMID 40069946, PMID 40648907, PMID 40669910, PMID 40673571, PMID 41433250, PMID 41572235
1UM1HL113203-01A1 (1), 2018 (1), 2019 (1), I01CX001789 (1), R01DA008391 (1), R01GM112871 (1), R01HL128658 (1), R37CA288577 (1), U01HL105371 (1)