8 completed, 8 recruiting, 1 not yet recruiting, 1 withdrawn. 16 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 7, Recruiting 7, Not yet recruiting 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic Sclerosis Hyperpolarized 129 Xenon Gas - Interstitial Lung Disease, Pulmonary Hypertension | Phase 2 | Not yet recruiting | Bastiaan Driehuys | 51 | 2026-11-01 | 2026-09-15 |
| Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma Hyperpolarized Xenon 129 - Severe Asthma | Recruiting | Bastiaan Driehuys | 5 | 2025-11-17 | 2025-11-20 | |
| 129 Xenon Imaging in Patients Treated With Sotatercept 129Xe Hyperpolarized - Pulmonary Hypertension, Pulmonary Arterial Hypertension | Phase 2 | Recruiting | Bastiaan Driehuys | 14 | 2025-10-27 | 2026-02-24 |
| Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia Inhaled Treprostinil (Tyvaso Nebulizer) - COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia | Phase 2 | Recruiting | Bastiaan Driehuys | 10 | 2025-09-29 | 2026-08-27 |
| 129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH) 129Xe Hyperpolarized - Pulmonary Arterial Hypertension, Idiopathic Pulmonary Arterial Hypertension | Phase 2 | Recruiting | Bastiaan Driehuys | 20 | 2024-08-12 | 2026-02-24 |
| Xenon MRI in Stable Pulmonary Hypertension (Jupiter AUGEAN) Hyperpolarized Xe129 - Pulmonary Artery Hypertension | Phase 2 | Withdrawn | Bastiaan Driehuys | 2024-03-15 | 2024-01-23 | |
| 129Xe MRI Cardiopulmonary Hyperpolarized Xe129, Oxygen Administration - Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension | Phase 2 | Recruiting | Bastiaan Driehuys | 125 | 2024-01-12 | 2026-02-04 |
| Pulmonary Hypertension SOLAR Hyperpolarized 129Xe - Interstitial Lung Disease, COPD | Phase 2 | Recruiting | Bastiaan Driehuys | 30 | 2023-11-08 | 2026-02-24 |
| Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease Hyperpolarized 129Xe - Interstitial Lung Diseases | Phase 2 | Completed | Bastiaan Driehuys | 47 | 2021-11-12 | 2026-08-05 |
| Xenon MRI Pulm Hypertension 129Xe Hyperpolarized - Pulmonary Hypertension, Pulmonary Arterial Hypertension | Phase 2 | Recruiting | Bastiaan Driehuys | 20 | 2021-09-01 | 2026-08-10 |
| Dual MRI for Cardiopulmonary COVID-19 Long Haulers Hyperpolarized 129Xenon gas - Covid19 | Phase 2 | Completed | Bastiaan Driehuys | 18 | 2021-05-26 | 2024-05-06 |
| Oxidative Stress in Asthma Hyperpolarized 129XeMRI - Asthma, Obesity | Phase 2 | Completed | Bastiaan Driehuys | 49 | 2021-04-01 | 2026-03-23 |
| Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI hyperpolarized 129Xe gas MRI, Bevespi Aerosphere - COPD | Phase 2 / Phase 3 | Completed | Bastiaan Driehuys | 20 | 2018-04-20 | 2021-01-19 |
| Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI Hyperpolarized 129Xenon gas - Pulmonary Vascular Disease | Phase 2 | Completed | Bastiaan Driehuys | 11 | 2018-03-29 | 2023-10-18 |
| Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging GE-141, Hyperpolarized 129Xenon gas, MRI - Pulmonary Vascular Disease | Phase 2 | Completed | Bastiaan Driehuys | 62 | 2017-05-03 | 2022-02-22 |
| Longitudinal MR Imaging of Pulmonary Function in Patients Receiving Thoracic Radiation Treatment Hyperpolarized 129-Xenon gas, MRI - Radiation Injury | Phase 2 | Completed | Bastiaan Driehuys | 25 | 2016-03-21 | 2023-02-17 |
| Using MRI to Visualize Regional Therapy Response in Idiopathic Pulmonary Fibrosis Hyperpolarized 129-Xenon gas, MRI - Idiopathic Pulmonary Fibrosis | Phase 1 | Completed | Bastiaan Driehuys | 64 | 2015-05-01 | 2021-10-11 |
| Hyperpolarized 129Xe MRI for Imaging Pulmonary Function Hyperpolarized 129Xenon Gas - Interstitial Lung Disease | Phase 2 | Recruiting | Bastiaan Driehuys | 445 | 2011-01-01 | 2026-01-16 |
Lung Diseases, Interstitial (5) · Pulmonary Arterial Hypertension (4) · Hypertension, Pulmonary (3) · Pulmonary Disease, Chronic Obstructive (3) · Asthma (2) · Familial Primary Pulmonary Hypertension (2) · Lung Diseases (2) · Anemia (1) · COVID-19 (1) · Connective Tissue Diseases (1) · Dyspnea (1) · Hypoxia (1) · Idiopathic Pulmonary Fibrosis (1) · Obesity (1) · Polycythemia (1)
Nebulizers and Vaporizers (1) · Oxygen (1)
United States (16)
Sudarshan Rajagopal, MD, PhD (4) · Joseph Mammarappallil, M.D. (3) · Joseph Mammarappallil, MD (2) · Loretta Que, MD (2) · Bastiann Driehays, PhD (1) · David Mummy, PhD (1) · Fawaz Alenezi, MD (1) · Joseph Mammarappallil (1) · Sean B Fain, Ph.D. (1) · Sudarshan Rajagopal, MD (1) · Yuh Chin Huang, MD (1)
PMID 23845983, PMID 25038105, PMID 25262951, PMID 25936684, PMID 25980630, PMID 27162620, PMID 27617823, PMID 27662575, PMID 28940334
R01HL126771 (3), R01HL105643 (1), R01HL153641 (1)