12 completed, 4 withdrawn, 2 terminated, 1 not yet recruiting. 21 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 21 | Completed 12, Withdrawn 4, Terminated 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 2 | 8 | Completed 3, Withdrawn 2, Not yet recruiting 1, Recruiting 1, Terminated 1 |
Follow Oxygen: new trials by email Literature Review of Oxygen trials Research Report on Oxygen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study Oxygen Gas for Inhalation, Standard of care - Inflammatory Bowel Disease (IBD), Crohn Disease | Phase 1 / Phase 2 | Not yet recruiting | University of British Columbia | 54 | 2026-09-01 | 2026-08-26 |
| A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia Oxygen, Room air - Pulmonary Hypertension | Phase 1 / Phase 2 | Withdrawn | Duke University | 2026-07-01 | 2026-09-03 | |
| NASA Prebreathe Study Altitude, 100% Oxygen - Decompression Sickness | Phase 1 | Completed | Duke University | 19 | 2025-05-05 | 2026-06-01 |
| Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air - OSA, Sleep Apnea | Phase 1 | Completed | University of California, San Diego | 182 | 2021-10-08 | 2026-05-11 |
| Treatment of U.S. Veterans With Mild Traumatic Brain Injury With Hyperbaric Oxygen Therapy Oxygen 100 % Gas for Inhalation, Hyperbaric Oxygen Therapy Chamber - Mild Traumatic Brain Injury, Hyperbaric Oxygen Therapy | Phase 1 | Completed | Nova Southeastern University | 40 | 2021-09-07 | 2025-08-26 |
| Study Testing Convalescent Plasma vs Best Supportive Care high-titer anti-Sars-CoV-2 plasma, oxygen therapy - Pneumonia, Interstitial | Phase 1 | Withdrawn | Baylor Research Institute | 2020-04-17 | 2026-01-26 | |
| Sleep Disordered Breathing With Opioid Use Hyperoxia, Acetazolamide - Sleep Apnea, Opioid Use | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 150 | 2019-05-02 | 2026-07-01 |
| Maternal Hyperoxygenation in Congenital Heart Disease Maternal Hyperoxygenation - Hypoplastic Left Heart Syndrome | Phase 1 / Phase 2 | Completed | The Hospital for Sick Children | 25 | 2018-02-02 | 2024-03-26 |
| Therapeutic Oxygen for Gastrointestinal Atony (TOGA) 100% Oxygen - Ileus, Ogilvie Syndrome | Phase 1 | Completed | University of Florida | 17 | 2018-01-25 | 2019-12-12 |
| A Pilot Study of RNS60 in Amyotrophic Lateral Sclerosis (ALS) RNS60 - ALS | Phase 1 | Completed | Sabrina Paganoni, M.D. | 24 | 2015-10-01 | 2021-05-28 |
| Predictors of Opioid-Induced Respiratory Depression (OIRD) Remifentanil, Oxygen, Carbon dioxide - Respiratory Depression | Phase 1 | Completed | Duke University | 30 | 2015-04-01 | 2020-03-10 |
| Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer gp96-Ig Vaccine, Theophylline, Oxygen - Non-Small Cell Lung Cancer, Non-small-cell Lung Carcinoma | Phase 1 | Withdrawn | Eckhard Podack | 2014-12-01 | 2014-11-17 | |
| Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers Salmonella typhi vaccine (Typhim Vi®), Oxygen (Oxymask®), Atorvastatin - Myocardial Infarction, Inflammation | Phase 1 | Completed | Karolinska Institutet | 36 | 2014-10-01 | 2017-12-11 |
| Three-level Injection Paravertebral Block vs General Anesthesia in Mastectomy paravertebral block, fentanyl, propofol, atracurium, lidocaine , adrenaline, ketamine bolus, midazolam - Radical Mastectomy | Phase 1 / Phase 2 | Completed | Ramathibodi Hospital | 60 | 2013-10-01 | 2014-03-10 |
| Hyperbaric Treatment of Traumatic Brain Injury (TBI) Oxygen at 1.5 ATA (atmospheres absolute). - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Barry Miskin, MD | 18 | 2013-04-01 | 2021-04-27 |
| Imaging Lung Function Using Oxygen Enhanced MRI Medical Grade Oxygen - COPD, Asthma | Phase 1 | Completed | Hal C Charles | 15 | 2012-01-01 | 2014-08-22 |
| A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache Oxygen - Cluster Headache | Phase 1 | Terminated | Geisinger Clinic | 4 | 2011-01-01 | 2019-07-11 |
| Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea) Bi-level positive airway pressure (BPAP), Oxygen, CPAP - Chronic Obstructive Airway Disease | Phase 1 / Phase 2 | Withdrawn | Brigham and Women's Hospital | 2010-11-01 | 2017-01-12 | |
| Application of Nasal Cannula With Oxygen Versus Air During Eye Surgery Under Local Anaesthetic oxygen - Hypoxia, Hypercapnia | Phase 1 | Completed | University of Malaya | 100 | 2010-05-01 | 2011-08-17 |
| Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation nitric oxide for inhalation, Oxygen - Lung Disease, Hypoxemia | Phase 1 / Phase 2 | Terminated | Mallinckrodt | 7 | 2002-05-01 | 2016-10-19 |
Showing 20 of 21. Sign in to see all of them.
Hypoxia (2) · Pulmonary Disease, Chronic Obstructive (2) · Sleep Apnea Syndromes (2) · Sleep Apnea, Obstructive (2) · Acidosis, Respiratory (1) · Acute Coronary Syndrome (1) · Alzheimer Disease (1) · Asthma (1) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Carcinoma, Non-Small-Cell Lung (1) · Cluster Headache (1) · Colonic Pseudo-Obstruction (1) · Crohn Disease (1) · Cystic Fibrosis (1)
Duke University (3) · Barry Miskin, MD (1) · Baylor Research Institute (1) · Brigham and Women's Hospital (1) · Eckhard Podack (1) · Geisinger Clinic (1) · Hal C Charles (1) · Karolinska Institutet (1) · Mallinckrodt (1) · Nova Southeastern University (1) · Ramathibodi Hospital (1) · Sabrina Paganoni, M.D. (1) · Shahid Beheshti University of Medical Sciences (1) · The Hospital for Sick Children (1) · University of British Columbia (1)
United States (13) · Canada (1) · Iran (1) · Malaysia (1) · Sweden (1) · Thailand (1)
Alison C Bested, MD FRCPC (1) · Atul Malhotra, MD (1) · Barry Miskin, MD (1) · Benno von Bormann, MD (1) · Brian C. Weiner, MD (1) · Cecil Charles, PhD (1) · Daniel Edmonston, MD, MHS (1) · David MacLeod, MB BS (1) · Ikechukwu Akunyili, MD (1) · Lennart Nilsson, MD, PHD (1) · Mike Seed, MD (1) · Nazem Atassi, MD (1) · Richard E Moon, MD (1) · Sabrina Paganoni, MD (1) · Susmita Chowdhuri, MD MS (1)
PMID 19183804, PMID 23369112, PMID 26056838, PMID 38629477, PMID 39131150, PMID 40135690, PMID 41025403
2014 (1)