The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.

• Nicotine Replacement Therapy (NRT, nicotine patch) (Drug): NRT: Nicotine Patch, Nicotine Gum
• Music intervention (Procedure): Music therapy carried out with Music care
• Biological collection (Other): Stool, blood, and saliva samples

Primary outcomes

• Compare the efficacy of a strategy combining music therapy with nicotine replacement therapy (NRT) with that of NRT alone in reducing tobacco craving. [Month 1]: Score of French Version of the Tabacco Craving Questionnaire-12 (FTCQ-12). It consist of 12 questions, each rated on a likert-type scale with 7 response options. Lower scores mean a better outcome.

Secondary outcomes

• Compare the evolution of craving between the two groups at 1, 2 and 3 months after the target date for smoking cessation [Month [1;2;3]]: Score of French Version Tabacco Craving Questionnaire-12 (FTCQ-12). it consist of 12 questions, each rated on a likert-type scale with 7 response options. Lower scores mean a better outcome.
• Compare the evolution of anxiety between the two groups at 1, 2 and 3 months after the target date for smoking cessation. [Month [1;2;3]]: HAD (Hospital Anxiety and Depression Scale) score. Maximum score for each score (total A, total D)=21. Score over 10 definite state of anxiety. Lower scores mean a better outcome.
• Compare the success of the treatment in reducing tobacco consumption between the two groups at 1, 2, 3, 6 and 12 months after the target date for smoking cessation [Month [1;2;3;6;12]]: Treatment success is defined as a three-class variable: self-reported abstinence of smoking reduction ≥50%.
• Compare the evolution of nicotine withdrawl symptoms between the two groups at 1, 2 and 3 months after the target date for smoking cessation. [Month [1;2;3]]: MNWS (Minnesota Nicotine Withdrawal Scale) score. It consist of 8 questions, each rated on a likert-type scale with 0-4 response options. Lower mean better outcome.
• Compare the evolution of impulsivity between the two groups at 1, 2 and 3 months after the target date for smoking cessation. [Month [1;2;3]]: UPPS (Impulsive Behavior Scale) score. It consist of 20 questions, each rated on a likert-type scale with 1-4 response options. Lower scores mean a better outcome.
• Compare the evolution of anxiety between the two groups at 1, 2, 3 months after the target date for smoking cessation [Month [1;2;3]]: STAI-Y (Form-Y of the State-Trait Anxiety Inventory) score. It consist of 20-item scales providing separate measures of state and trait anxiety (S-Anxiety and T-Anxiety, respectively). On a 4-point Likert scale (1-4), a score equal to 4 indicates the presence of a higher level of anxiety.

Other outcomes

• Compare the composition of the gut microbiota (in terms of overall diversity and individual species) between non-smokers and abstinent and non-abstinent smokers three months after starting smoking cessation treatment. [Month 3]: The composition of the gut microbiota was characterised after metagenomic sequencing of the 16S rDNA V1-V3 region.
• Compare the rates of BDNF promoter I and IV methylation between non-smokers and abstinent and non-abstinent smokers three months after they started smoking cessation treatment. [Month 3]: Methylation levels at BDNF gene promoters I and IV, as measured by pyrosequencing after bisulfite conversion, in non-smokers and smokers (abstinent and non-abstinent).
• Assess the predictive value of the gut microbiota in determining the success of attempts to quit smoking. [Month 3]: The predictive value of alpha and beta diversity, taxonomic distribution and predicted metabolome, as determined by metagenomic sequencing of 16S rDNA V1-V3, on the success of smoking cessation at three months of treatment in smokers at inclusion (T0).
• Evaluate the predictive value of BDNF methylation levels in promoters I and IV. [Month 3]: The predictive value of the BDNF methylation level, as measured by pyrosequencing, on smoking cessation success at three months of treatment in smokers at inclusion (T0).

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Age >=18 years old
* To be a free subject, without guardianship, curatorship or subordination.
* To be affiliated with a Social Security scheme, or benefit from it through a third party.
* Written Informed consent signed by the subject after receiving clear and honest information about the study.
* Healthcare professionals include administrative and technical professionals working in the healthcare sector in the private, public or independent sectors.
* Smoking at least 6 cigarettes per day for at least 6 months.
* Being motivated to quit smoking

Exclusion Criteria:

* Unstabilized depression
* Psychosis and/or cognitive impairment and/or mental retardation or chronic use of medication for these disorders,
* Addictive comorbidity such as alcoholism or abuse of substances other than tobacco,
* Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, persons staying in a health or social institution, and finally patients in emergency situations.
* Roommates, spouses, or family members already included in the study (to avoid interference with treatment)
* Contraindication to nicotine replacement therapy (NRT)
* Use of medication to quit smoking (NRT, bupropion), cognitive behavioral therapy (CBT), hypnotherapy, acupuncture in the last 3 months
* Use of an electronic cigarette to quit smoking in the last 3 months
* Concurrent participation in another clinical research study until visit V4 of this study.

MUSICAT-BIO Exclusion Criteria (ancillary study, 30 healthy volunteers):

* Not be a smoker or former smoker, nor a vaper or former vaper (including nicotine-free vaping),
* Chronic diseases,
* Systemic corticosteroid treatment,
* Anti-infective treatment in the previous 3 weeks (antibiotics, antivirals, antifungals, etc.),
* Concurrent participation in another interventional clinical research study.