26 completed, 9 terminated, 5 withdrawn, 3 unknown. 15 Phase 2, 11 Phase 3, 9 Phase 1, 9 Phase 4, 6 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nesiritide for Ventilated Congestive Heart Failure Nesiritide - Congestive Heart Failure, Mechanical Ventilation | Unknown | Shanghai Zhongshan Hospital | 30 | 2020-05-14 | 2020-07-02 | |
| Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1 Valsartan, LCZ696, Bradykinin - Hypertension | Phase 4 | Terminated | Vanderbilt University Medical Center | 4 | 2018-11-15 | 2025-08-03 |
| Impact of Nesiritide on Early Postoperative Recovery After Total Cavo-Pulmonary Connection Surgery in Children Nesiritide, Normal saline - Congenital Heart Disease, Total Cavo-pulmonary Connection | Not applicable | Unknown | China National Center for Cardiovascular Diseases | 108 | 2017-07-05 | 2017-07-06 |
| Nesiritide in Hypertension Nesiritide, Placebo - Hypertension | Phase 1 / Phase 2 | Recruiting | Oslo University Hospital | 15 | 2015-12-01 | 2018-01-03 |
| Testosterone Regulation of the Natriuretic Peptide System Testosterone, Nesiritide, Leuprolide - Hypertension | Not applicable | Withdrawn | Massachusetts General Hospital | 2015-02-01 | 2017-10-19 | |
| BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects Nesiritide, Saline - Obesity, Cardiovascular Disease | Phase 1 | Completed | AdventHealth Translational Research Institute | 4 | 2013-11-01 | 2018-02-14 |
| Nesiritide and Renal Function After the Total Artificial Heart nesiritide, placebo - Congestive Heart Failure, Cardiorenal Syndrome | Phase 4 | Terminated | Virginia Commonwealth University | 2 | 2013-04-01 | 2016-02-08 |
| Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure Nesiritide, Tadalafil, Placebo - Congestive Heart Failure | Phase 1 / Phase 2 | Completed | Mayo Clinic | 43 | 2012-02-01 | 2018-03-22 |
| Pharmacogenetics of Ace Inhibitor-Associated Angioedema Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin - Hypertension, Diabetes Type 2 | Not applicable | Completed | Vanderbilt University | 44 | 2011-11-01 | 2015-11-04 |
| Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study Placebo, Nesiritide, Dopamine - Acute Heart Failure | Phase 2 | Completed | Duke University | 360 | 2010-08-01 | 2014-08-21 |
| Does Nesiritide Provide Renal Protection Nesiritide, Placebo - Renal Failure | Phase 2 | Completed | University of Florida | 37 | 2010-04-01 | 2014-06-06 |
| Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function. BNP (nesiritide), Placebo - Left Ventricular Diastolic Dysfunction | Phase 1 / Phase 2 | Completed | Mayo Clinic | 41 | 2008-03-01 | 2015-07-01 |
| Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery nesiritide, milrinone, placebo - Heart Defects, Congenital | Phase 2 | Terminated | John M Costello | 106 | 2007-10-01 | 2018-06-25 |
| Role of Natriuretic Peptides in the Treatment of Acutely Decompensated Heart Failure Patient With Obstructive Airways Disease Nesiritide, Placebo - Heart Failure | Phase 3 | Terminated | The Alfred | 6 | 2007-09-01 | 2015-06-25 |
| Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF Nesiritide - Heart Failure, Congestive, Dyspnea | Phase 4 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2007-08-01 | 2015-11-11 | |
| A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure Nesiritide, Placebo - Heart Decompensation | Phase 3 | Completed | Scios, Inc. | 7141 | 2007-05-01 | 2013-03-08 |
| BNP Therapy Observation Unit Outcomes STudy (BOOST) Nesiritide - Congestive Heart Failure | Phase 4 | Terminated | Emory University | 17 | 2007-03-01 | 2015-02-09 |
| An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure Nesiritide - Heart Decompensation, Congestive Heart Failure | Phase 3 | Completed | Xian-Janssen Pharmaceutical Ltd. | 41 | 2006-10-01 | 2014-02-28 |
| Nesiritide Therapy to Preserve Function of the Left Ventricle After Myocardial Infarction Nesiritide, Placebo - Acute Myocardial Infarction | Phase 2 | Completed | Mayo Clinic | 59 | 2006-09-01 | 2014-09-09 |
| Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy Nesiritide, Nitroglycerin - Acute Decompensated Heart Failure | Phase 4 | Completed | Western University of Health Sciences | 89 | 2006-07-01 | 2013-08-30 |
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Heart Failure (27) · Renal Insufficiency (9) · Cardiomyopathies (7) · Hypertension (5) · Dyspnea (4) · Cardiovascular Diseases (3) · Heart Defects, Congenital (3) · Cardio-Renal Syndrome (2) · Coronary Disease (2) · Diabetes Mellitus (2) · Dyspnea, Paroxysmal (2) · Myocardial Ischemia (2) · Obesity (2) · Acute Kidney Injury (1) · Cardiomyopathy, Dilated (1)
Scios, Inc. (9) · Mayo Clinic (5) · Horng Chen (3) · Emory University (2) · University of Wisconsin, Madison (2) · Vanderbilt University Medical Center (2) · AdventHealth Translational Research Institute (1) · Boston Children's Hospital (1) · Brigham and Women's Hospital (1) · China National Center for Cardiovascular Diseases (1) · Duke University (1) · Ejaz, Abulate A, MD (1) · John M Costello (1) · M.D. Anderson Cancer Center (1) · Massachusetts General Hospital (1)
United States (27) · China (4) · Australia (2) · Canada (2) · Norway (2) · Argentina (1) · Brazil (1) · Bulgaria (1) · Chile (1) · Colombia (1) · France (1) · Germany (1) · Greece (1) · India (1) · Israel (1)
Horng H. Chen, M.D. (6) · Adam H Miller (1) · Alessandro Cataliotti, MD, PhD (1) · Anju Nohria, MD (1) · Daniel Wu, MD (1) · Douglas Ander, MD (1) · Duan Yabing, MD (1) · Eugene Braunwald, MD (1) · Henry Krum, MBBS FRACP PhD (1) · Horng H Chen, MD (1) · Janet M Simsic, MD (1) · Jean-Bernard Durand, MD (1) · John M Costello, MD (1) · John M Costello, MD MPH (1)
PMID 10400005, PMID 39878152, PMID 11911755, PMID 12486437, PMID 15342289, PMID 19660420, PMID 19752530, PMID 19808265, PMID 21362524, PMID 21576282, PMID 21732835, PMID 22157521, PMID 22497823, PMID 22595385, PMID 23032196, PMID 23122795, PMID 23770519, PMID 23899930, PMID 24046475, PMID 24054337, PMID 24247300, PMID 24464687, PMID 24516103, PMID 24622005, PMID 24906491, PMID 25074507, PMID 25158865, PMID 25281655, PMID 26304935, PMID 26874387, PMID 26927285, PMID 26988350, PMID 27512103, PMID 27514750, PMID 27623769, PMID 28641792, PMID 29431103, PMID 29781109, PMID 30354576, PMID 31606362, PMID 31909303, PMID 32473378, PMID 32747497, PMID 33775110, PMID 34405565, PMID 36314126, PMID 37725680
P01HL076611 (5), UL1RR024150 (5), R01HL084155 (2), 2015 (1), R01HL036634 (1), U01HL084904 (1)