75 completed, 21 unknown, 12 terminated, 6 withdrawn. 124 Phase 2, 22 Phase 3, 15 Phase 1.
Follow Morphine: new trials by email Literature Review of Morphine trials Research Report on Morphine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads) - Spine Surgery, Postoperative Pain Management | Phase 2 | Not yet recruiting | Ganesh M. Shankar | 100 | 2027-01-01 | 2026-04-16 |
| Phase II Clinical Study of the Efficacy and Safety of HSK55718 in the Treatment of Abdominal Postoperative Pain Low dose HSK55718, Medium Dose HSK55718, High dose HSK55718 - Pain After Abdominal Surgery | Phase 2 | Recruiting | Yingyong Zhou,MD,PhD | 200 | 2026-05-23 | 2026-07-21 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery HSK55718 dose level1, HSK55718 dose level2, HSK55718 dose level 3 - Pain After Surgery | Phase 2 | Recruiting | Haisco Pharmaceutical Group Co., Ltd. | 200 | 2026-05-22 | 2026-05-28 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Orthopedic Surgery HSK55718 dose level 1, HSK55718 dose level 2, HSK55718 dose level 3 - Pain After Surgery | Phase 2 | Not yet recruiting | Haisco Pharmaceutical Group Co., Ltd. | 200 | 2026-04-01 | 2026-04-27 |
| Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients. Green Tea Extract with Morphine, Active Comparator: Triple Mixture Oral Rinse for Radiation-Induced Mucositis - Squamous Cell Carcinoma of the Head and Neck, Oral Mucositis | Phase 1 / Phase 2 | Not yet recruiting | Fundacion Clinica Valle del Lili | 40 | 2025-12-28 | 2025-04-01 |
| Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty Morphine, Vancomycin - Primary Total Knee Arthroplasty, Intraosseous Morphine Injection | Phase 2 | Completed | Carilion Clinic | 100 | 2024-12-01 | 2025-09-10 |
| A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery HSK21542 dose level 1, HSK21542 dose level 2, Placebo - Postoperative Pain Management | Phase 2 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 161 | 2024-09-13 | 2026-09-29 |
| Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section Sebacoyl Dinalbuphine Ester, Morphine - Postsurgical Pain, Cesarean Section | Phase 2 / Phase 3 | Recruiting | Dalin Tzu Chi General Hospital | 120 | 2024-05-06 | 2025-05-09 |
| Opioid/Benzodiazepine Polydrug Abuse: Aim 3 Morphine, Alprazolam, Placebo - Opioid Abuse, Benzodiazepine Abuse | Phase 2 | Recruiting | Wayne State University | 24 | 2024-03-13 | 2025-12-30 |
| Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip Surgeries Caudal epidural analgesia, Ultrasound-guided Combined Pericapsular Nerve Group Block, Ultrasound-guided Lateral Femoral Cutaneous Nerve Block - Pericapsular Nerve Group Block | Phase 2 | Completed | Kasr El Aini Hospital | 68 | 2024-03-01 | 2026-06-16 |
| A Phase Ⅱ Study to Evaluate the Efficacy and Safety of YZJ-4729 in Patients With Moderate to Severe Acute Pain After Abdominal Surgery YZJ-4729, morphine, placebo - Pain | Phase 2 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 179 | 2023-12-26 | 2026-06-29 |
| Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds Morphine Sulfate, Lidocaine Hcl 2% Jelly - Wounds and Injuries, Cancer Pain | Phase 2 | Unknown | Instituto Nacional de Cancer, Brazil | 106 | 2023-09-12 | 2023-09-28 |
| Platelet Reactivity With Fentanyl, Morphine, or no Narcotic Morphine, Fentanyl - Fentanyl, Platelet Reactivity | Phase 2 | Terminated | Corewell Health South | 21 | 2022-08-31 | 2025-05-21 |
| Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) Dexmedetomidine Hydrochloride, Morphine Sulfate - Hypoxic-Ischemic Encephalopathy, Pain | Phase 2 | Completed | University of Utah | 50 | 2022-06-20 | 2026-03-06 |
| A Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery SHR8554 Injection, Saline Solution, Morphine - Pain | Phase 2 / Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 320 | 2022-05-11 | 2023-12-26 |
| Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid Ketorolac, Opioid - Acute Pancreatitis | Phase 2 | Terminated | Boston Children's Hospital | 23 | 2022-03-15 | 2026-01-08 |
| Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy Bupivacaine, Morphine, Lidocaine - Cancer Debulking, Enlarged Uterus | Phase 2 | Terminated | Washington University School of Medicine | 110 | 2022-01-18 | 2025-07-31 |
| Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures Ketamine, Morphine - Pain, Acute | Phase 2 | Withdrawn | The University of Texas Health Science Center, Houston | 2022-01-01 | 2022-04-27 | |
| Efficacy of Injectable Fentanyl in Sublingual Route Versus Oral Morphine Syrup for Breakthrough Pain Fentanyl Citrate 50Mcg/Ml Inj_#1, Morphine - Pain, Breakthrough | Phase 1 / Phase 2 | Completed | Department of Medical Services Ministry of Public Health of Thailand | 20 | 2021-06-15 | 2022-08-31 |
| Inhaled Cannabinoids Versus Immediate-release Oral Opioids for the Management of Breakthrough Cancer Pain PPP001, Morphine sulfate or Hydromorphone or Oxycodone - Cancer, Breakthrough Cancer Pain | Phase 2 | Unknown | Tetra Bio-Pharma | 20 | 2021-05-26 | 2021-07-28 |
Showing 20 of 124. Sign in to see all of them.
Pain (31) · Pain, Postoperative (21) · Acute Pain (10) · Agnosia (9) · Chronic Pain (7) · Opioid-Related Disorders (7) · Neoplasms (3) · Pruritus (3) · Anemia, Sickle Cell (2) · Breast Neoplasms (2) · Cancer Pain (2) · Diabetes Mellitus (2) · Emergencies (2) · Neonatal Abstinence Syndrome (2) · Neoplasm Metastasis (2)
Assiut University (13) · Haisco Pharmaceutical Group Co., Ltd. (3) · Montefiore Medical Center (3) · Centre Hospitalier Universitaire Saint Pierre (2) · Hospira, now a wholly owned subsidiary of Pfizer (2) · INSYS Therapeutics Inc (2) · Jiangsu HengRui Medicine Co., Ltd. (2) · Johns Hopkins University (2) · KK Women's and Children's Hospital (2) · Kasr El Aini Hospital (2) · National Institute on Drug Abuse (NIDA) (2) · QRxPharma Inc. (2) · Trevena Inc. (2) · University of British Columbia (2) · AbbVie (prior sponsor, Abbott) (1)
United States (50) · Egypt (17) · Canada (8) · China (8) · Poland (3) · Belgium (2) · Brazil (2) · France (2) · Greece (2) · Israel (2) · Serbia (2) · Singapore (2) · Thailand (2) · Colombia (1) · Croatia (1)
Andrew K Chang, MD (2) · Gillian Lauder, Dr. (2) · Giovanni DeCastro (2) · Patricia T. Richards, MD, Ph.D. (2) · Philippe Goffard, MD (2) · Abdelrady S Ibrahim, MD (1) · Ahmed F Mahmoud Hussein, MS.c (1) · Albert W Pearsall, MD (1) · Amit Grover, MB BCh BAO (1) · Apkar V Apkarian, PhD (1) · Arlyne Thung, MD (1) · Ayman A Mamdouh, Ass Prof (1)
PMID 24238862, PMID 10353500, PMID 10690153, PMID 11050519, PMID 11133630, PMID 12298311, PMID 12411815, PMID 12761013, PMID 12770663, PMID 12934209, PMID 14667752, PMID 15471273, PMID 15513495, PMID 16452738, PMID 16651569, PMID 17581533, PMID 18258412, PMID 18648238, PMID 19214642, PMID 19508134, PMID 19520544, PMID 19535720, PMID 19663845, PMID 1977542, PMID 21215653, PMID 21470608, PMID 2164935, PMID 21765198, PMID 22522612, PMID 22797672, PMID 23370085, PMID 23380337, PMID 23545428, PMID 23611363, PMID 2367246, PMID 23719070, PMID 24106351, PMID 24227768, PMID 24385406, PMID 24666686, PMID 24806873, PMID 25077099, PMID 25187581, PMID 25302181, PMID 25773480, PMID 25791027, PMID 25902891, PMID 25971957, PMID 26349564, PMID 27002003
R01DA008045 (2), 2008 (1), 2014 (1), 2019 (1), P01NS041386 (1), P50DA009236 (1), R01DK079974 (1)