14 completed, 2 terminated. 9 Phase 1, 5 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 8, Terminated 1 |
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous TRV250 Part A: TRV250-20mg/ml, Placebo, Part B: TRV250 Dose 1 - Migraines | Phase 1 | Terminated | Trevena Inc. | 9 | 2019-11-11 | 2021-09-22 |
| Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty Oliceridine, Placebo, Morphine - Acute Pain | Phase 3 | Completed | Trevena Inc. | 407 | 2016-05-01 | 2020-10-23 |
| Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy Oliceridine, Placebo, Morphine - Acute Pain | Phase 3 | Completed | Trevena Inc. | 418 | 2016-05-01 | 2020-09-25 |
| A Open-label Study to Evaluate the Safety of TRV130 in Patients With Acute Pain TRV130 - Acute Pain | Phase 3 | Completed | Trevena Inc. | 768 | 2015-12-01 | 2020-09-24 |
| A Pilot Study of TRV130 for the Treatment of Fracture Pain TRV130 - Pain | Phase 2 | Terminated | Trevena Inc. | 1 | 2015-10-20 | 2020-09-07 |
| A Pharmacokinetic, Safety and Tolerability Study in Healthy Adult Males TRV734 - Healthy | Phase 1 | Completed | Trevena Inc. | 18 | 2015-02-01 | 2015-11-18 |
| A Study of TRV130 for the Treatment of Pain After Abdominoplasty TRV130, Morphine, Placebo - Pain | Phase 2 | Completed | Trevena Inc. | 200 | 2014-12-01 | 2020-09-16 |
| Study of the Effects of TRV130, at Therapeutic and Supra Therapeutic Doses, on QTc Intervals TRV130, Moxifloxacin, Placebo - Healthy | Phase 1 | Completed | Trevena Inc. | 63 | 2014-12-01 | 2017-05-12 |
| A Safety, Tolerability, PD and PK Study in Healthy Adults Open-label TRV734 125 mg, TRV734 blinded, Oxycodone IR 10 mg - Healthy | Phase 1 | Completed | Trevena Inc. | 75 | 2014-07-01 | 2014-12-05 |
| A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects Radiolabeled TRV130 - Healthy | Phase 1 | Completed | Trevena Inc. | 6 | 2014-06-01 | 2015-11-18 |
| A Study of TRV130 for the Treatment of Pain After Bunionectomy TRV130, Morphine, Placebo - Acute Pain | Phase 2 | Completed | Trevena Inc. | 333 | 2014-04-01 | 2020-09-16 |
| A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure TRV027 Dose #1, TRV027 Dose #2, TRV027 Dose #3 - Acute Decompensated Heart Failure | Phase 2 | Completed | Trevena Inc. | 620 | 2013-12-01 | 2018-07-26 |
| Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects TRV130 1.5 mg, TRV130 3 mg, TRV130 4.5 mg - Pain, Acute | Phase 1 | Completed | Trevena Inc. | 30 | 2013-07-01 | 2014-03-11 |
| Single Ascending Dose Study of Intravenous TRV130A in Healthy Adult Males TRV130A, Dextrose in Water - Healthy | Phase 1 | Completed | Trevena Inc. | 74 | 2012-01-01 | 2012-08-24 |
| Study to Evaluate TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Renal Dysfunction TRV120027, Normal Saline - Heart Failure, Kidney Disease | Phase 1 | Completed | Trevena Inc. | 17 | 2011-08-01 | 2012-08-27 |
| Study to Evaluate the Effects of TRV120027 in Patients With Heart Failure TRV120027, Placebo - Heart Failure | Phase 1 / Phase 2 | Completed | Trevena Inc. | 33 | 2010-12-01 | 2017-07-11 |
Acute Pain (5) · Heart Failure (2) · Pain (2) · Agnosia (1) · Fractures, Bone (1) · Kidney Diseases (1) · Migraine Disorders (1)
((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (8) · Morphine (5) · Glucose (3) · Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH (3) · Water (3) · Moxifloxacin (1) · Saline Solution (1)
United States (15) · Czechia (2) · Poland (2) · Argentina (1) · Bulgaria (1) · Canada (1) · Germany (1) · Hungary (1) · Israel (1) · Romania (1) · Russia (1) · Slovakia (1) · United Kingdom (1)
Franck Skobieranda, MD (5) · Alan S. Marion, MD, PhD (1) · David G Soergel, M.D. (1) · David G Soergel, MD (1) · David G. Soergel, MD (1) · David Soergel, MD (1) · Franck Skobieranda (1)
PMID 23813302, PMID 24122908, PMID 24954166, PMID 31162798, PMID 31814753