83 completed, 14 terminated, 14 unknown, 7 withdrawn. 135 Phase 3, 22 Phase 2.
Follow Morphine: new trials by email Literature Review of Morphine trials Research Report on Morphine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia rachi morphine anesthesia, laparotomy, Lidocaine IV - Digestive System Disease, Surgery | Phase 3 | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 76 | 2026-09-01 | 2026-08-25 |
| Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction Methoxyflurane, Morphine - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 700 | 2026-06-01 | 2026-03-03 |
| Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department Parecoxib, Morphine - Sickle-Cell Disease with Crisis | Phase 3 | Not yet recruiting | Oman Medical Speciality Board | 226 | 2026-05-01 | 2025-03-20 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery HSK21542, Placebo, morphine - Postoperative Pain Management | Phase 3 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 405 | 2025-08-05 | 2026-08-26 |
| Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine Morphine, IN fentanyl, IN ketamine - Limb Injury | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2025-02-26 | 2026-03-27 |
| Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries Morphine, Placebo - Pain, Postoperative | Phase 3 | Completed | Cairo University | 50 | 2024-08-03 | 2025-12-05 |
| Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain Ketorolac Tromethamine, Morphine Sulfate, normal saline - Acute Pain, Abdomen, Acute | Phase 3 | Recruiting | University of Calgary | 495 | 2024-05-27 | 2024-06-24 |
| Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section Sebacoyl Dinalbuphine Ester, Morphine - Postsurgical Pain, Cesarean Section | Phase 2 / Phase 3 | Recruiting | Dalin Tzu Chi General Hospital | 120 | 2024-05-06 | 2025-05-09 |
| Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery spinal analgesia with morphine and bupivacaine, lidocaine infusion - Other Specified Disorders of Kidney and Ureter, Benign Neoplasm of Ureter | Phase 3 | Recruiting | Hans Bahlmann | 220 | 2024-04-09 | 2026-02-05 |
| Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery Methadone, Morphine - Pain, Postoperative | Phase 3 | Completed | Chinese University of Hong Kong | 86 | 2024-03-01 | 2026-10-23 |
| CPL-01 in the Management of Postoperative Pain After Bunionectomy Local anesthetic injection of CPL-01, Naropin, 0.5% Injectable Solution, Placebo - Bunion, Post-operative Pain | Phase 3 | Completed | Cali Pharmaceuticals LLC | 616 | 2023-05-22 | 2026-04-30 |
| Herniorrhaphy for Postoperative Pain local anaesthetic injection of CPL-01, Morphine (rescue medication), Acetaminophen (rescue medication) - Hernia, Inguinal, Post Operative Pain | Phase 3 | Completed | Cali Pharmaceuticals LLC | 518 | 2023-04-18 | 2026-04-30 |
| Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients Methadone, Morphine - Pain, Postoperative, Pain, Acute | Phase 3 | Completed | Chinese University of Hong Kong | 86 | 2023-01-15 | 2026-10-23 |
| Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy Ketorolac Tromethamine, Morphine Sulfate, Intravenous Placebo for NTM-001 - Pain, Postoperative | Phase 3 | Suspended | Neumentum, Inc. | 341 | 2022-12-14 | 2026-04-23 |
| Methadone for 'Adenocarcinopathic' Pain Treatment Methadone, Morphine - Cancer Pain, Adenocarcinoma | Phase 3 | Withdrawn | Ottawa Hospital Research Institute | 2022-09-01 | 2022-12-05 | |
| A Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery SHR8554 Injection, Saline Solution, Morphine - Pain | Phase 2 / Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 320 | 2022-05-11 | 2023-12-26 |
| Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen Ibuprofen 800 mg, Morphine Sulfate, Ibuprofen 400 mg plus Acetaminophen 1000 mg - Multiple Trauma, Acute Pain Due to Trauma | Phase 3 | Completed | Isfahan University of Medical Sciences | 150 | 2022-03-15 | 2023-09-07 |
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Pain, Postoperative (39) · Pain (35) · Agnosia (14) · Acute Pain (9) · Cancer Pain (6) · Neoplasms (6) · Chronic Pain (5) · Emergencies (5) · Neonatal Abstinence Syndrome (5) · Opioid-Related Disorders (4) · Pulmonary Disease, Chronic Obstructive (4) · Abdominal Pain (3) · Anemia, Sickle Cell (3) · Dyspnea (3) · Osteoarthritis (3)
Assiut University (5) · Jiangsu HengRui Medicine Co., Ltd. (4) · QRxPharma Inc. (4) · Alza Corporation, DE, USA (3) · Assistance Publique - Hôpitaux de Paris (3) · Grünenthal GmbH (3) · Hospira, now a wholly owned subsidiary of Pfizer (3) · Mundipharma (China) Pharmaceutical Co. Ltd (3) · Cali Pharmaceuticals LLC (2) · Chinese University of Hong Kong (2) · Columbia University (2) · Flinders University (2) · Foisor Orthopedics Clinical Hospital (2) · Hamilton Health Sciences Corporation (2) · Isfahan University of Medical Sciences (2)
United States (43) · Canada (16) · France (13) · Egypt (7) · China (6) · Poland (4) · Sweden (4) · Norway (3) · Romania (3) · United Kingdom (3) · Colombia (2) · Germany (2) · Hong Kong (2) · Israel (2) · Latvia (2)
David C Currow, MD, PhD (2) · Eduardo Bruera, MD (2) · Erol Onel (2) · Franck Skobieranda, MD (2) · Gillian Lauder, Dr. (2) · James B. Jones, MD, PharmD (2) · Mohamed Eltorki, MBChB (2) · Patricia T. Richards, MD, Ph.D. (2) · Abbot Laptook, MD (1) · Abhik Das, PhD (1) · Adam Czynski, DO (1)
PMID 21519308, PMID 24238862, PMID 25774458, PMID 26695349, PMID 34231914, PMID 16478902, PMID 17138198, PMID 17397698, PMID 18028044, PMID 18504090, PMID 18784493, PMID 19050084, PMID 20382445, PMID 21075272, PMID 21436683, PMID 21765198, PMID 21904098, PMID 21956081, PMID 23611363, PMID 24156640, PMID 24781562, PMID 24806873, PMID 24817819, PMID 24906437, PMID 25077099, PMID 25485150, PMID 25624387, PMID 25773480, PMID 25902891, PMID 27002003, PMID 27247487, PMID 27387971, PMID 27524403, PMID 28468518, PMID 28716797, PMID 29136228, PMID 29716637, PMID 29913015, PMID 30467809, PMID 31162798, PMID 31315670, PMID 31612359, PMID 31691849, PMID 31987653, PMID 32375747, PMID 32765053, PMID 33649058, PMID 3376761, PMID 35236391, PMID 35383071
2023 (2), 2025 (2), 2005 (1), 2008 (1), 2019 (1), P20GM125507 (1), R01CA124481 (1), R01CA231471 (1), R01DA029076 (1), R01DA043519 (1), U01HD116253 (1), U24HL137907 (1)