36 completed, 9 unknown, 2 withdrawn, 1 not yet recruiting. 49 Phase 1, 15 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 49 | Completed 36, Unknown 9, Withdrawn 2, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 15 | Completed 9, Unknown 4, Not yet recruiting 1, Withdrawn 1 |
Follow Morphine: new trials by email Literature Review of Morphine trials Research Report on Morphine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients. Green Tea Extract with Morphine, Active Comparator: Triple Mixture Oral Rinse for Radiation-Induced Mucositis - Squamous Cell Carcinoma of the Head and Neck, Oral Mucositis | Phase 1 / Phase 2 | Not yet recruiting | Fundacion Clinica Valle del Lili | 40 | 2025-12-28 | 2025-04-01 |
| Morphine, Midazolam and Dexmedetomidine in the Management of Acute Cardiogenic Pulmonary Edema, Safety and Efficacy Injection - Sedative Adverse Reaction | Phase 1 | Completed | Menoufia University | 84 | 2024-04-01 | 2025-06-26 |
| Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions Cannabidiol, Placebo, Citalopram - Cannabidiol, Drug Induced Liver Injury | Phase 1 | Completed | Food and Drug Administration (FDA) | 241 | 2024-02-08 | 2025-07-31 |
| A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users. Morphine, AZD4041, Placebo - Opioid Use Disorder | Phase 1 | Completed | AstraZeneca | 45 | 2022-08-31 | 2024-11-15 |
| Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy Levomethadone HCl, Methadone, Morphine Sulfate - Opioid Use Disorder, Moderate | Phase 1 | Withdrawn | Lyndra Inc. | 2022-02-28 | 2023-01-19 | |
| Evaluation of the Interactions of Cannabidiol (CBD) With Morphine Morphine Sulfate - Opioid Use Disorder | Phase 1 | Unknown | National Institute on Drug Abuse (NIDA) | 60 | 2021-11-04 | 2024-03-27 |
| Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival Morphine, Ketamine Injectable Solution, Saline 0.9% - Cardiac Arrest | Phase 1 | Unknown | University Hospital, Akershus | 240 | 2021-10-01 | 2021-06-11 |
| Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption Ketamine - Nephrectomy | Phase 1 | Completed | Egymedicalpedia | 100 | 2021-09-01 | 2022-10-27 |
| Efficacy of Injectable Fentanyl in Sublingual Route Versus Oral Morphine Syrup for Breakthrough Pain Fentanyl Citrate 50Mcg/Ml Inj_#1, Morphine - Pain, Breakthrough | Phase 1 / Phase 2 | Completed | Department of Medical Services Ministry of Public Health of Thailand | 20 | 2021-06-15 | 2022-08-31 |
| A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants ASP8082, morphine, Placebo - Opioid Use Disorder | Phase 1 | Completed | Astellas Pharma Global Development, Inc. | 24 | 2020-06-30 | 2024-11-21 |
| Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine Morphine, Placebo - Healthy | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 44 | 2019-11-12 | 2023-01-12 |
| Pramipexole and Morphine for Renal Colic Pramipexole, Morphine, Placebo oral tablet - Renal Colic | Phase 1 / Phase 2 | Completed | East Carolina University | 19 | 2019-10-28 | 2023-03-08 |
| Combined Epidural Morphine and Midazolam on Postoperative Pain midazolam - Acute Postoperative Pain | Phase 1 / Phase 2 | Unknown | Assiut University | 20 | 2019-07-01 | 2021-02-24 |
| Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics Morphine - Organic Cation Transporter 1, Morphine | Phase 1 | Completed | University of Southern Denmark | 86 | 2018-06-01 | 2020-06-29 |
| Development of a Morphine Pharmacokinetic and Pharmacodynamic Model for the Neonatal Population Morphine - Pain, Drug Effect | Phase 1 / Phase 2 | Withdrawn | The Hospital for Sick Children | 2017-12-01 | 2020-02-25 | |
| Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain Oxycodone or morphine sulfate immediate release (MSIR), Placebo Treatment - Low Back Pain | Phase 1 | Completed | Brigham and Women's Hospital | 35 | 2017-01-06 | 2026-02-04 |
| Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity Morphine Sulfate, Dexmedetomidine, Bupivacaine - Immune System Suppression | Phase 1 / Phase 2 | Unknown | Assiut University | 30 | 2017-01-01 | 2021-01-14 |
| Paravertebral Morphine Versus Dexmedetomidine on Acute and Chronic Postmastectomy Pain bupivicaine, morphine, Dexmedetomidine - Acute Pain, Chronic Pain | Phase 1 / Phase 2 | Unknown | Assiut University | 90 | 2016-10-01 | 2018-01-12 |
| Low-dose Ketamine for Acute Pain in the Emergency Department Ketamine, Placebos, Morphine - Pain | Phase 1 | Unknown | Faculty of Medicine, Sousse | 125 | 2016-01-01 | 2017-01-31 |
| First Evaluation of Morphine Hydrochloride by Nebulisation in Healthy Volunteers Morphine, Fentanyl - Acute Pain | Phase 1 / Phase 2 | Completed | University Hospital, Rouen | 35 | 2014-05-13 | 2019-10-24 |
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Pain (6) · Opioid-Related Disorders (5) · Acute Pain (4) · Agnosia (3) · Cancer Pain (2) · Neonatal Abstinence Syndrome (2) · Neoplasms (2) · Pain, Postoperative (2) · Renal Colic (2) · Breakthrough Pain (1) · Carcinoma, Squamous Cell (1) · Chemical and Drug Induced Liver Injury (1) · Chemically-Induced Disorders (1) · Chronic Pain (1) · Colonic Neoplasms (1)
Actavis Inc. (6) · Assiut University (3) · AstraZeneca (2) · Pfizer (2) · Ranbaxy Inc. (2) · Thomas Jefferson University (2) · Alberta Health services (1) · Astellas Pharma Global Development, Inc. (1) · BioLineRx, Ltd. (1) · Brigham and Women's Hospital (1) · Costantine Albany (1) · Dalhousie University (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · East Carolina University (1) · Egalet Ltd (1)
United States (23) · Egypt (5) · Canada (3) · Tunisia (2) · Belgium (1) · Brazil (1) · Colombia (1) · Denmark (1) · Finland (1) · France (1) · Israel (1) · Malaysia (1) · Taiwan (1) · Thailand (1)
Daniel V. Freeland, DO (3) · James P. Doherty, DO (2) · Alfred S Barritt, MD (1) · Bo Fransson, MD (1) · Christine Andersen, M.Sc. (1) · Costantine Albany, M.D. (1) · David G Soergel, MD (1) · Debra Kelsh, MD (1) · Eric Strain, M.D. (1) · Franco Carli, Professor (1) · Gregory Hammer (1)
PMID 10353500, PMID 18201934, PMID 18258412, PMID 18694901, PMID 19508134, PMID 20925688, PMID 21215653, PMID 23380337, PMID 23745947, PMID 24227768, PMID 24385406, PMID 24666686, PMID 24954166, PMID 25467190, PMID 26349564, PMID 35306524, PMID 37170709, PMID 39411383, PMID 39428602, PMID 40622698
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