167 completed, 29 unknown, 25 terminated, 13 withdrawn. 254 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 254 | Completed 167, Unknown 29, Terminated 25, Withdrawn 13, Recruiting 10, Not yet recruiting 6, Active not recruiting 2, Suspended 2 |
Follow Morphine: new trials by email Literature Review of Morphine trials Research Report on Morphine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 1150 | 2027-01-01 | 2026-06-03 |
| BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP) buprenorphine, morphine - Cesarean Delivery | Phase 4 | Recruiting | Icahn School of Medicine at Mount Sinai | 180 | 2026-10-07 | 2026-10-16 |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon - Laparoscopic Surgery, Visceral Pain, Postoperative | Phase 4 | Recruiting | Peking University First Hospital | 140 | 2026-04-14 | 2026-10-30 |
| Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery Tegileridine, morphine - Scoliosis; Adolescence, Pain After Surgery | Phase 4 | Recruiting | Peking Union Medical College Hospital | 171 | 2026-04-08 | 2026-10-13 |
| Optimal Intrathecal Morphine Dose for Better Post Cesarean Section Analgesia 0.5% bupivacaine heavy with fentanyl, 0.5% bupivacaine heavy with fentanyl plus morphine 50 mcg, 0.5% bupivacaine heavy with fentanyl plus morphine100 mcg - Post Cesarean Section Pain | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 180 | 2026-04-01 | 2026-05-01 |
| Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy Nefopam 120mg/day infusion, Lidocaine Infusion, Peridural - Pancreatoduodenectomy, Pain Management | Phase 4 | Recruiting | Iuliu Hatieganu University of Medicine and Pharmacy | 93 | 2026-03-01 | 2026-03-24 |
| Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery Tegileridine, Morphine - Pain, Postoperative, Postoperative Ileus | Phase 4 | Recruiting | Xiangya Hospital of Central South University | 152 | 2026-02-24 | 2026-08-17 |
| Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis - Postoperative Nausea and Vomiting, Postoperative Pain | Phase 4 | Completed | Universitas Indonesia | 63 | 2026-02-02 | 2026-10-01 |
| Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine Morphine, Bupivacaine, Fentanyl - Opioid Use Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2026-02-01 | 2026-03-09 | |
| Anrikefon-based Patient-controlled Intravenous Analgesia After Laparoscopic Surgery High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon - Laparoscopic Surgery, Visceral Pain, Postoperative | Phase 4 | Terminated | Peking University First Hospital | 13 | 2025-12-25 | 2026-04-09 |
| Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine - Postoperative Pain, Cesarean Delivery | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 92 | 2025-10-15 | 2025-07-30 |
| Comparison of Pruritus Incidence After Intrathecal Morphine 0.1 vs 0.2 mg in Cesarean Section Morphine Sulfate - Pruritus Caused by Drug | Phase 4 | Recruiting | Khon Kaen University | 69 | 2025-06-01 | 2025-07-08 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Role of Prophylactic Antiemetics in Women Receiving Intrathecal Morphine and Lipophilic Opioids Added to Bupivacaine for Cesarean Section Morphine - .25 mg, fentanyl + morphine, Ondansetron + Dexamethasone - Cesarean Section | Phase 4 | Not yet recruiting | Assiut University | 100 | 2024-12-01 | 2024-11-25 |
| Effect of Dexmedetomidine on Postoperative Pain in Spinal Anesthesia for Cesarean Section at Assuit University Hospital Dexmedetomidine, morphine, Bupivacaine - Cesarean Section | Phase 4 | Active not recruiting | Assiut University | 90 | 2024-11-10 | 2026-11-06 |
| Ketamine for Sedation in Severe Traumatic Brain Injury Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam - Severe Traumatic Brain Injury, Intracranial Hypertension | Phase 4 | Suspended | Henry M. Jackson Foundation for the Advancement of Military Medicine | 50 | 2024-09-23 | 2025-07-14 |
| Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery Fentanyl-Morphine, Morphine - Intraoperative Pain | Phase 4 | Unknown | Seoul National University Hospital | 186 | 2024-09-20 | 2024-10-01 |
| Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction Intraosseous Morphine - Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries | Phase 4 | Recruiting | The Methodist Hospital Research Institute | 84 | 2024-08-19 | 2026-04-09 |
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Pain, Postoperative (66) · Agnosia (47) · Pain (36) · Acute Pain (12) · Chronic Pain (11) · Osteoarthritis (7) · Renal Colic (7) · Emergencies (6) · Anemia, Sickle Cell (5) · Neonatal Abstinence Syndrome (5) · Postoperative Nausea and Vomiting (5) · Intestinal Obstruction (4) · Low Back Pain (4) · Osteoarthritis, Knee (4) · Angina, Unstable (3)
Pacira Pharmaceuticals, Inc (7) · Mahidol University (6) · Assiut University (5) · Antonios Likourezos (4) · Collegium Medicum w Bydgoszczy (4) · Copenhagen University Hospital, Rigshospitalet (4) · Cukurova University (4) · Istanbul University (4) · Peking University First Hospital (4) · Pfizer (4) · Seoul National University Hospital (4) · University of Parma (4) · Akdeniz University (3) · B.P. Koirala Institute of Health Sciences (3) · Baylor College of Medicine (3)
United States (76) · Turkey (Türkiye) (13) · China (10) · Denmark (10) · France (10) · Italy (9) · Thailand (8) · Poland (7) · Canada (6) · Israel (6) · Netherlands (6) · Czechia (5) · South Korea (5) · Egypt (4) · Malaysia (4)
Guido Fanelli, MD (3) · Sergey Motov, MD (3) · Andrea Cornini, MD (2) · Andrew Herring, MD (2) · Bozidar Duplancic (2) · Dan Marinescu, MD (2) · Dong-Xin Wang, MD, PhD (2) · Hrvoje Vucemilovic (2) · Ivan Velat (2) · Ivo Juginovic (2) · Jacek Kubica, MD., PhD. (2) · Jiri Malek, M.D. (2) · Jorge Marcet, MD (2)
PMID 25018650, PMID 33238043, PMID 34231914, PMID 27782769, PMID 1015603, PMID 10422923, PMID 10740539, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11472277, PMID 12411815, PMID 12548273, PMID 12560416, PMID 14622770, PMID 14690106, PMID 15983470, PMID 16798774, PMID 16846542, PMID 17138203, PMID 17403800, PMID 17413915, PMID 18073548, PMID 18272093, PMID 18611915, PMID 18686750, PMID 18723709, PMID 18762870, PMID 18806056, PMID 18987053, PMID 19135997, PMID 19157368, PMID 19174373, PMID 19209273, PMID 19462494, PMID 19535182, PMID 19647342, PMID 19690943, PMID 20736233, PMID 21040558, PMID 21294923, PMID 21385158, PMID 22104479, PMID 22186009, PMID 22227789, PMID 22285545, PMID 22286518, PMID 22494596, PMID 22506940, PMID 22568450
2014 (2), 2005 (1), 2015 (1), 2016 (1), 2017 (1), K23DA020681 (1), K23GM071400 (1), R01DA036564 (1), R01DA042985 (1)