155 completed, 48 unknown, 25 terminated, 17 recruiting. 276 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 276 | Completed 155, Unknown 48, Terminated 25, Recruiting 17, Not yet recruiting 16, Withdrawn 10, Active not recruiting 2, Suspended 2, Enrolling by invitation 1 |
Follow Fentanyl: new trials by email Literature Review of Fentanyl trials Research Report on Fentanyl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Does the Volume of Medication Affect the Success of Labor Epidural Analgesia administration of bupivacaine 7.5 mg and fentanyl 24 mcg every 40 minutes - Labor Pain and to Reduce Pain | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 70 | 2026-10-30 | 2026-10-05 |
| Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy Ketamine and Dexmedetomidine, Fentanyl - Nephrolithiasis, Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-02 |
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| Fentanyl and Rocuronium for Tracheal Intubation in Newborns Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation. - Infant, Premature, Intubation, Intratracheal | Phase 4 | Not yet recruiting | UEA - Universidade Do Estado Do Amazonas | 102 | 2026-09-01 | 2026-07-01 |
| Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy Fentanyl and Propofol, Esketamine and remimazolam - Adverse Respiratory Events, Hypoxemia | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2026-08-01 | 2026-08-06 |
| Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy Fentanyl, Ketamine - Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 84 | 2026-08-01 | 2026-06-26 |
| The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding Trial Ciprofol, Fentanyl - Pediatric, Anesthesia Induction | Phase 4 | Recruiting | Huazhong University of Science and Technology | 180 | 2026-06-15 | 2026-07-13 |
| Intravenous Acetaminophen and Ketorolac for Pain Management During Extracorporeal Shockwave Lithotripsy IV midazolam, IV fentanyl, IV acetaminophen - Extracorporeal Shockwave Lithotripsy | Phase 4 | Enrolling by invitation | Horizon Health Network | 266 | 2026-04-01 | 2026-04-13 |
| Optimal Intrathecal Morphine Dose for Better Post Cesarean Section Analgesia 0.5% bupivacaine heavy with fentanyl, 0.5% bupivacaine heavy with fentanyl plus morphine 50 mcg, 0.5% bupivacaine heavy with fentanyl plus morphine100 mcg - Post Cesarean Section Pain | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 180 | 2026-04-01 | 2026-05-01 |
| Patient Quality of Recovery After TAVR With Different Sedation Regimens Propofol, Dexmedetomidine, Midazolam - Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis | Phase 4 | Recruiting | David Lyubashevsky | 126 | 2026-03-16 | 2026-04-29 |
| Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy Nalbuphine, Fentanyl - Laryngoscopy, Hemodynamic Changes | Phase 4 | Recruiting | Rawalpindi Institute of Cardiology | 98 | 2026-02-21 | 2026-02-27 |
| Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine Morphine, Bupivacaine, Fentanyl - Opioid Use Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2026-02-01 | 2026-03-09 | |
| Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis Dexmedetomidine, Fentanyl (IV) - Opioid Free Anesthesia | Phase 4 | Recruiting | Nashwa Ahmed | 30 | 2026-01-30 | 2026-02-05 |
| Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy Fentanyl, Ketorolac, Nerve of Arnold Block - Postoperative Pain | Phase 4 | Not yet recruiting | University of South Alabama | 300 | 2026-01-01 | 2025-12-11 |
| Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine Spinal Anesthesia with Bupivacaine and Fentanyl, Crystalloid Coload 1000 mL, Cesarean Delivery - Cesarean Delivery, Spinal Anesthesia for Cesarean Section | Phase 4 | Recruiting | Mansoura University | 200 | 2026-01-01 | 2026-01-14 |
| Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy Propofol + fentanyl + Atracurium, Isoflurane and Atracurium - Diabete Mellitus, VATS | Phase 4 | Active not recruiting | Ain Shams University | 60 | 2025-12-01 | 2026-03-27 |
| Hemodynamic and Cardiac Effects of Dexmedetomidine Versus Fentanyl by Intravenous Infusion as Adjuncts to General Anesthesia in Patients Undergoing Major Abdominal Cancer Surgeries. Fentanyl (IV), Dexmedetomidine - Abdominal Cancer Surgeries | Phase 4 | Not yet recruiting | Assiut University | 70 | 2025-11-01 | 2025-10-09 |
| Patient Preference and Long-term Outcomes in Persistent Spinal Pain Syndrome: A Prospective Study Comparing Spinal Cord Stimulation to Intrathecal Drug Delivery. Pain pump, Bupivacain 0.625%/Fentanyl 2mcg/ml, Spinal Cord Stimulator (SCS) - Persistent Spinal Pain Syndrome | Phase 4 | Recruiting | University Hospitals Cleveland Medical Center | 36 | 2025-10-13 | 2026-02-03 |
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Pain, Postoperative (43) · Agnosia (35) · Pain (34) · Labor Pain (13) · Acute Pain (9) · Chronic Pain (6) · Emergencies (6) · Cancer Pain (5) · Delirium (4) · Opioid-Related Disorders (4) · Osteoarthritis (4) · Patient Satisfaction (4) · Breakthrough Pain (3) · Colonic Neoplasms (3) · Critical Illness (3)
Assiut University (9) · Duke University (6) · Ain Shams University (4) · Cairo University (4) · Medical University of Warsaw (4) · University of Texas Southwestern Medical Center (4) · Columbia University (3) · Johns Hopkins University (3) · Nashwa Ahmed (3) · Oslo University Hospital (3) · Tanta University (3) · University Hospitals Cleveland Medical Center (3) · University of California, San Francisco (3) · Al-Azhar University (2) · Antonios Likourezos (2)
United States (82) · Egypt (25) · China (15) · Italy (9) · Canada (8) · Turkey (Türkiye) (8) · Denmark (7) · Netherlands (7) · Brazil (6) · Finland (6) · Israel (6) · Poland (6) · South Korea (6) · Norway (5) · Thailand (5)
Giorgio Danelli, MD (2) · Julia C Finkel, MD (2) · Ronald H Wender, MD (2) · Salim Hayek, MD (2) · Sergey Motov, MD (2) · XiaoFeng Shen, MD (2) · Xudong Yang, MD (2) · Aaron M Berg, MD (1) · Adaira Landry, B.A. (1) · Ahmed Mukhtar (1) · Ahmed T Bahnaswy (1) · Ahmet Burak Erdem, M.D. (1) · Albert Sundberg, MD, PhD (1)
PMID 38666154, PMID 10793585, PMID 10960384, PMID 11555797, PMID 11727145, PMID 12351295, PMID 12487041, PMID 12847519, PMID 1326621, PMID 15094977, PMID 15576519, PMID 17006084, PMID 17307778, PMID 17519263, PMID 17913605, PMID 17959952, PMID 18073548, PMID 18090011, PMID 18385265, PMID 18637615, PMID 18826731, PMID 19135997, PMID 19209273, PMID 19254307, PMID 19388915, PMID 19535182, PMID 19617584, PMID 20736233, PMID 20821238, PMID 21040558, PMID 21063553, PMID 21197290, PMID 21295639, PMID 21461792, PMID 21897504, PMID 2221417, PMID 22476448, PMID 22527063, PMID 22568450, PMID 22678319, PMID 22893770, PMID 23059961, PMID 23607840, PMID 24370612, PMID 24595069, PMID 25168967, PMID 25254902, PMID 25329822, PMID 25429720, PMID 26359465
2008 (3), 2004 (1), 2005 (1), 2014 (1), 2015 (1), 2018 (1), 2023 (1), R01DA042985 (1), R01HD114678 (1), R01HL095748 (1), R03HD090617 (1), R21DA055848 (1), UL1TR000124 (1)