49 completed, 6 terminated, 4 withdrawn, 3 unknown. 68 Phase 1, 15 Phase 2.
Follow Vomiting: new trials by email Literature Review of Vomiting trials Research Report on Vomiting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults NS003 Ondansetron HCl microspheres powder for nasal application, Ondansetron Solution for IV infusion 8mg - Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV) | Phase 1 | Recruiting | Nasus Pharma | 12 | 2026-09-15 | 2026-10-09 |
| QLM2010 Comparative Pharmacokinetic Study With 2-Minute Intravenous Administration apripitant and palonosetron injectable emulsion, palonosetron hydrochloride injection, apripitant injection (CINVANTI) - Chemotherapy-Induced Nausea and Vomiting (CINV) | Phase 1 | Not yet recruiting | Qilu Pharmaceutical (Hainan) Co., Ltd. | 42 | 2026-09-01 | 2026-09-14 |
| Hyperemesis Gravidarum Risk Reduction With Metformin Metformin Extended Release Oral Tablet - Hyperemesis Gravidarum | Phase 1 / Phase 2 | Recruiting | University of Southern California | 224 | 2026-07-13 | 2026-07-22 |
| Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients Ondansetron (Zofran), chewing gum, Ondansetron + Chewing gum - Postoperative Nausea and Vomiting (PONV) | Phase 1 | Active not recruiting | Makassed General Hospital | 90 | 2025-08-22 | 2025-10-01 |
| The Relationship Between NLR and PONV and ESPB Erector Spinae Plane Block, 0.9% physiological saline (20ml) injection under ultrasound-guided Erector Spinae Plane Block (ESPB). - Erector Spinae Plane Block, Neutrophil to Lymphocyte Ratio | Phase 1 | Not yet recruiting | Qianfoshan Hospital | 220 | 2025-08-01 | 2025-07-29 |
| Phase I PK and Safety Study of Ondansetron Inhalation Powder LPI-1503, Matching Placebo of LPI-1503, IV Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Luxena Pharmaceuticals, Inc. | 24 | 2025-03-13 | 2026-03-27 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks Low, non-weight based dose of Dexamethasone and Dexmedetomidine in peripheral nerve blocks, Ropivacaine with low, non weight based Dexamethasone additive - Postoperative Pain, Nausea and Vomiting, Postoperative | Phase 1 / Phase 2 | Active not recruiting | University of Arizona | 100 | 2024-10-10 | 2026-02-13 |
| Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation Glycopyrrolate, Anisodamine - Nausea and Vomiting | Phase 1 / Phase 2 | Completed | Jie Chen | 130 | 2023-10-01 | 2024-09-05 |
| Pharmacokinetic and Pharmacodynamic Evaluation of Formulations of Δ9-THC Pharmacokinetic and pharmacodynamic profile of THC oral formulations with Dronabinol as comparator - Nausea Post Chemotherapy, Vomiting | Phase 1 / Phase 2 | Unknown | LaSanta S A S | 334 | 2023-08-15 | 2023-02-01 |
| A Clinical Study to Evaluate Cyclopofol Injection for the Prevention of Postoperative Nausea and Vomiting Heptaflurane combined Cyclophenol, Heptaflurane, Cyclophenol - Nausea and Vomiting | Phase 1 | Unknown | Mengchang Yang | 300 | 2023-08-02 | 2023-07-27 |
| Endeavor to Stop Nausea/Vomiting Associated With Pregnancy (E-SNAP) Mirtazapine - Pregnancy, Severe Nausea and Vomiting | Phase 1 / Phase 2 | Withdrawn | Northwestern University | 2022-06-13 | 2024-12-11 | |
| Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children Dexamethasone, Ondansetron, Dexmedetomidine - Postoperative Nausea and Vomiting, Post Operative Pain | Phase 1 | Completed | Tanta University | 4 | 2021-10-27 | 2022-04-05 |
| Olanzapine for the Prevention of Postoperative Nausea and Vomiting Placebo, 5 mg Olanzapine Tablets, 10 mg Olanzapine Tablets - Postoperative Nausea | Phase 1 / Phase 2 | Completed | Amani Hassan Abdel-Wahab | 132 | 2021-03-15 | 2023-03-09 |
| The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy Cannabidiol - Lean Body Mass, Cannabis | Phase 1 | Completed | University of Copenhagen | 32 | 2020-12-01 | 2023-07-24 |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S QBS10072S - Astrocytoma, Brain Cancer | Phase 1 | Completed | Quadriga Biosciences, Inc. | 15 | 2020-07-20 | 2023-01-18 |
| Evaluation of Meclizine Orodispersible Tablet Pharmacokinetic in Human Volunteers Meclizine Hydrochloride - Emesis | Phase 1 / Phase 2 | Unknown | Mansoura University | 6 | 2020-06-01 | 2020-09-25 |
| Study of APD421 With and Without Ondansetron APD421, Placebo, Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Acacia Pharma Ltd | 30 | 2018-07-17 | 2018-10-01 |
| Relative Bioavailability of an Extemporaneous Oral Suspension of Aprepitant in Healthy Adult Volunteers Aprepitant Capsule 125 MG, Aprepitant oral suspension 20 mg/mL - Chemotherapy-induced Nausea and Vomiting | Phase 1 | Completed | The Hospital for Sick Children | 17 | 2017-08-10 | 2022-04-11 |
| Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride Chlorpromazine Hydrochloride - Anti-Psychotic, Management of Manifestations of Psychotic Disorders | Phase 1 | Completed | Cycle Pharmaceuticals Ltd. | 20 | 2016-11-01 | 2017-11-14 |
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Nausea (30) · Postoperative Nausea and Vomiting (15) · Neoplasms (4) · Anorexia (3) · Breast Neoplasms (3) · Pain (3) · Pain, Postoperative (3) · Brain Neoplasms (2) · Gastroparesis (2) · Hyperemesis Gravidarum (2) · Melanoma (2) · Abdominal Pain (1) · Appetitive Behavior (1) · Astrocytoma (1)
Pathological Conditions, Signs and Symptoms (68) · Signs and Symptoms (68) · Signs and Symptoms, Digestive (68) · Pathologic Processes (17) · Postoperative Complications (16) · Nausea (13) · Neurologic Manifestations (11) · Digestive System Diseases (6) · Pain (6) · Neoplasms by Site (5) · Nervous System Diseases (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Urogenital Diseases (5)
Ondansetron (16) · casopitant (10) · Aprepitant (8) · Granisetron (6) · Dexamethasone (5) · fosaprepitant (4) · Palonosetron (3) · Tablets (3) · rolapitant (3) · Cyclophosphamide (2) · Dexmedetomidine (2) · Dronabinol (2) · Ketoconazole (2) · Saline Solution (2) · halofantrine (2)
GlaxoSmithKline (11) · Merck Sharp & Dohme LLC (7) · Kyowa Kirin Pharmaceutical Development Ltd (3) · Tesaro, Inc. (3) · Acacia Pharma Ltd (2) · Sandoz (2) · University of Southern California (2) · Accenture (1) · Amani Hassan Abdel-Wahab (1) · AstraZeneca (1) · Charleston Laboratories, Inc (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Cycle Pharmaceuticals Ltd. (1) · Duke University (1) · Hamad Medical Corporation (1)
United States (29) · Canada (4) · Australia (2) · China (2) · Egypt (2) · Spain (2) · Brazil (1) · Colombia (1) · Denmark (1) · India (1) · Israel (1) · Lebanon (1) · Mexico (1) · Netherlands (1) · New Zealand (1)
Dennis Vargo, MD (3) · Soran Hong, M.D. (2) · Agop Y. Bedikian, MD (1) · Agustin Garcia (1) · Alaa Y. Darwesh, Dr (1) · Amani H Abdel-wahab, MD (1) · Anh D Dang, PhD (1) · Belen Sadaba, MD, PhD (1) · Bernard P Schachtel, M.D (1) · Bruno Gagnon, MD, MSC (1) · Christine M. Walko, PharmD, BCOP (1)
PMID 16408862, PMID 17513629, PMID 19205754, PMID 19617379, PMID 20220045, PMID 22096279, PMID 22245954, PMID 22520120, PMID 22739139, PMID 2286697, PMID 23904932, PMID 23936162, PMID 24587006, PMID 25670522, PMID 25770814, PMID 25834396, PMID 25885838, PMID 27121336, PMID 31303716, PMID 31694495, PMID 31819674, PMID 31862004, PMID 31913911, PMID 32839657, PMID 40856942, PMID 40950965
2008 (2), P30CA016086 (1), P30CA069533 (1), R21HD105101 (1), R43AT004489 (1)