32 completed, 5 terminated, 3 unknown, 2 recruiting. 10 Not applicable, 8 Phase 3, 6 Phase 2, 5 Phase 1, 4 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 9, Unknown 1 |
| Phase 3 | 8 | Completed 8 |
| Phase 2 | 6 | Completed 4, Terminated 2 |
| Phase 1 | 5 | Completed 5 |
| Phase 4 | 4 | Completed 2, Terminated 1, Unknown 1 |
Follow Visceral Leishmaniasis: new trials by email Literature Review of Visceral Leishmaniasis trials Research Report on Visceral Leishmaniasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Recurrent Visceral Leishmaniasis in HIV Co-Infection Hiv, Visceral Leishmaniasis | Recruiting | Institute of Tropical Medicine, Belgium | 20 | 2025-10-21 | 2026-03-23 | |
| Human Bioequivalence Study of Liposomal Amphotericin B for Injection Test product (Liposomal amphotericin B for injection, Sichuan Huiyu Pharmaceutical Co., Ltd.), Reference product (AmBisome®, Astellas Pharma US Inc.) - Invasive Fungal Infections, Neutropenic Fever | Not applicable | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 58 | 2025-05-25 | 2026-05-27 |
| Human Bioequivalence Study of Amphotericin B Liposome for Injection Amphotericin B Liposome for Injection (strength: 50 mg, Sichuan Huiyu Pharmaceutical Co., Ltd.), Amphotericin B Liposome for Injection (trade name: Ambisome®, strength: 50 mg, MAH: Gilead Sciences) - Invasive Fungal Infections, Neutropenic Fever | Not applicable | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 42 | 2025-05-13 | 2026-05-22 |
| Leishmania Antigen Rapid Diagnostic Test Proof-of-Concept and Validation Study Antigen detection Rapid Diagnostic Test prototype - Visceral Leishmaniasis | Terminated | Foundation for Innovative New Diagnostics, Switzerland | 72 | 2023-12-20 | 2025-01-28 | |
| Clinical Prognostic Score to Predict Relapse in VL No intervention - Visceral Leishmaniasis | Recruiting | Institute of Tropical Medicine, Belgium | 741 | 2023-02-03 | 2024-03-05 | |
| Evaluation to Assess the Usability of rK28 for the Diagnosis of Visceral Leishmaniasis in Kenya rK28 - Visceral Leishmaniasis | Unknown | Foundation for Innovative New Diagnostics, Switzerland | 625 | 2022-12-31 | 2023-04-07 | |
| A Study to Assess Immune Response Status in Patients Before and After Treatment for Visceral Leishmaniasis Sodium stibogluconate / paramomycin - Visceral Leishmaniasis | Active not recruiting | University of York | 216 | 2022-05-22 | 2025-07-24 | |
| Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of Cure ELISA, LAMP, Cytokine Release Assay - Visceral Leishmaniasis | Completed | Foundation for Innovative New Diagnostics, Switzerland | 60 | 2021-09-01 | 2026-09-17 | |
| Single Oral Dose Escalation Study of DNDI-0690 in Healthy Subjects DNDI-0690, Placebo of DNDI-0690 - Visceral Leishmaniasis, Cutaneous Leishmaniases | Phase 1 | Completed | Drugs for Neglected Diseases | 64 | 2019-04-04 | 2022-12-20 |
| A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy Subjects LXE408, Placebo, Iohexol - Visceral Leishmaniasis, Chagas Disease | Phase 1 | Completed | Novartis Pharmaceuticals | 88 | 2018-12-21 | 2026-09-09 |
| LAMP Assay for the Diagnosis of Visceral Leishmaniasis Visceral Leishmaniasis | Completed | Prof. Dawit Wolday | 500 | 2018-10-01 | 2023-12-20 | |
| Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition Amphotericin B Liposome, AmBisome (Amphotericin B) Liposome - Visceral Leishmaniasis | Phase 1 | Completed | Aurobindo Pharma Ltd | 140 | 2018-05-02 | 2019-08-26 |
| Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa Miltefosine, Paromomycin, Sodium stibogluconate - Visceral Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 439 | 2018-01-24 | 2024-02-29 |
| Improved Case Detection and Vector Control for Visceral Leishmaniasis Inesfly Paint, IDWL (1m), ITN (KO-Tab 123) - Visceral Leishmaniasis | Not applicable | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 202 | 2016-01-01 | 2020-01-14 |
| Asymptomatic Leishmania Infection in HIV Patients Visceral Leishmaniasis | Terminated | Institute of Tropical Medicine, Belgium | 540 | 2015-09-01 | 2018-10-11 | |
| Pharmacokinetics/Safety of Miltefosine Allometric Dose for the Treatment of Visceral Leishmaniasis in Children in Eastern Africa Miltefosine - Visceral Leishmaniasis | Phase 2 | Completed | Drugs for Neglected Diseases | 30 | 2015-05-01 | 2016-10-11 |
| Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. Liposomal Amphotericin B, Miltefosine - Visceral Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 59 | 2014-07-01 | 2019-04-08 |
| Single Dose Liposomal Amphotericin B for Visceral Leishmaniasis AMBISOME - Visceral Leishmaniasis | Phase 4 | Unknown | Banaras Hindu University | 1300 | 2014-06-01 | 2014-01-22 |
| Phase 1 LEISH-F3 + SLA-SE Vaccine Trial in Healthy Adult Volunteers LEISH-F3 + SLA-SE, LEISH-F3 + GLA-SE - Visceral Leishmaniasis | Phase 1 | Completed | Access to Advanced Health Institute (AAHI) | 39 | 2014-04-01 | 2016-02-23 |
| Trial to Determine Efficacy of Fexinidazole in Visceral Leihmaniasis Patients in Sudan Fexinidazole - Visceral Leishmaniasis | Phase 2 | Terminated | Drugs for Neglected Diseases | 14 | 2013-11-01 | 2015-10-30 |
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Leishmaniasis, Visceral (43) · Leishmaniasis (3) · Disease (2) · Febrile Neutropenia (2) · Invasive Fungal Infections (2) · Malnutrition (2) · Acquired Immunodeficiency Syndrome (1) · Brucellosis (1) · Chagas Disease (1) · Drug-Related Side Effects and Adverse Reactions (1) · Growth Disorders (1) · Leishmaniasis, Cutaneous (1) · Leptospirosis (1) · Liver Abscess, Amebic (1) · Malaria (1)
Euglenozoa Infections (43) · Infections (43) · Parasitic Diseases (43) · Protozoan Infections (43) · Vector Borne Diseases (43) · Leishmaniasis (40) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Skin Diseases (4) · Skin Diseases, Infectious (4) · Skin Diseases, Parasitic (4) · Skin and Connective Tissue Diseases (4) · Bacterial Infections and Mycoses (3) · Agranulocytosis (2) · Cytopenia (2)
liposomal amphotericin B (11) · Paromomycin (9) · miltefosine (7) · Amphotericin B (6) · amphotericin B, deoxycholate drug combination (4) · Antimony Sodium Gluconate (3) · Injections (2) · Long-Term Synaptic Depression (2) · Meglumine Antimoniate (2) · Acetylcysteine (1) · Albendazole (1) · Combined Modality Therapy (1) · Iohexol (1) · Iron (1) · LXE408 (1)
Drugs for Neglected Diseases (9) · Banaras Hindu University (7) · Foundation for Innovative New Diagnostics, Switzerland (3) · Institute of Tropical Medicine, Belgium (3) · International Centre for Diarrhoeal Disease Research, Bangladesh (3) · PATH (3) · Access to Advanced Health Institute (AAHI) (2) · Sichuan Huiyu Pharmaceutical Co., Ltd (2) · University of Brasilia (2) · Aurobindo Pharma Ltd (1) · Hospital Universitário Professor Edgard Santos (1) · Instituto de Salud Carlos III (1) · London School of Hygiene and Tropical Medicine (1) · National Human Genome Research Institute (NHGRI) (1) · Novartis Pharmaceuticals (1)
India (13) · Ethiopia (9) · Bangladesh (6) · Kenya (6) · Sudan (5) · Brazil (4) · Uganda (3) · China (2) · Nepal (2) · United States (2) · Cambodia (1) · Democratic Republic of the Congo (1) · United Kingdom (1)
Shyam Sundar, MD (7) · Qing Wen (2) · Ahmed M Musa, MD PhD (1) · Ahmed M Musa, MD, Prof (1) · Amanuel Haile, MD (1) · Amrendra K Aditya, MD (1) · Ana LT Rabello, MD PhD (1) · Andrea L de Carvalho, MD (1) · Anna Marie Beckmann, PhD (1) · Beena Varghese, Dr (1) · C P Thakur, MD (1) · Carlos HN Costa, MD PhD (1) · Clive Davies, Dr. (1) · Devendra Nath, MD (1) · Dinesh Mondal, PhD (1)
PMID 17582067, PMID 17682988, PMID 18781879, PMID 19663597, PMID 19959405, PMID 20126269, PMID 20147716, PMID 21049063, PMID 21129762, PMID 21255828, PMID 21375777, PMID 22665599, PMID 22724029, PMID 23029576, PMID 24454970, PMID 24743328, PMID 26203904, PMID 26496648, PMID 27812090, PMID 28327804, PMID 28558062, PMID 28662034, PMID 30188978, PMID 30653490, PMID 30789910, PMID 31593563, PMID 34125865, PMID 34310340, PMID 34789175, PMID 35491421, PMID 36164254
2018 (1)