174 completed, 94 unknown, 39 recruiting, 12 terminated. 174 Not applicable, 37 Phase 2, 29 Phase 3, 29 Phase 4, 15 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| Structured Nursing Intervention for Adults With Poorly Controlled Asthma: A Pilot Study RESPiraIA-Asma - Asthma, Medication Adherence | Not applicable | Not yet recruiting | Hospital San Carlos, Madrid | 30 | 2026-10-01 | 2026-09-18 |
| Personalised Behavioural Intervention in Cancer Screening Programmes Personalised baseline feedback report, CANVIA mobile app intervention, Additional health professional support - Dietary and Lifestyle Behaviour Change | Not applicable | Not yet recruiting | Fundació d'investigació Sanitària de les Illes Balears | 162 | 2026-10-01 | 2026-07-23 |
| Preventing Breast Cancer Therapy-related Cardiovascular Toxicity With a Daily-adapted Program With Mhealth Support Individualised health recommentations, General health recommendations, Individualised physical exercise program - Breast Cancer Female | Not applicable | Not yet recruiting | Universidad de Granada | 102 | 2026-09-01 | 2026-05-06 |
| Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data Acute Hypoxemic Respiratory Failure | Recruiting | Hospital del Mar Research Institute (IMIM) | 300 | 2026-06-04 | 2026-06-08 | |
| Colchicine to Reduce Coronary Artery Inflammation in People With HIV Colchicine 0.5 mg, Placebo - HIV Infection, Cardiovascular Diseases (CVD) | Phase 2 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 90 | 2026-06-01 | 2026-07-15 |
| Effectiveness of Best Care Practices in Acute Stroke in Conventional Hospitalization (BEST CARE ICTUS_HC) BEST CARE ICTUS_HC BUNDLE - Stroke, Acute Stroke | Not applicable | Recruiting | University of Malaga | 700 | 2026-05-12 | 2026-06-04 |
| A Scalable Trans Diagnostic Intervention Targeting Adolescent Agency Supported by Conversational AI (AGENCIA) AGENCIA Digital Self-Guided, AGENCIA In-person With Digital Assistant - Irritability, Neurodevelopmental Disorders | Not applicable | Not yet recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 465 | 2026-04-01 | 2026-04-30 |
| Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes iCBT with human interaction, Psychoeducational videos - Depression Symptoms, Depression - Major Depressive Disorder | Not applicable | Recruiting | Francesc Colom, PsyD, PhD | 120 | 2026-03-02 | 2026-10-09 |
| Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults. Transgender Individuals | Not yet recruiting | Milagros Rocha Barajas | 94 | 2026-02-14 | 2026-02-06 | |
| UNMASK: Unveiling the Pathobiology of Metabolic Dysfunction-Associated Steatotic Liver Disease for the Discovery of Novel Therapeutics and Biomarkers Multimodal lifestyle intervention - MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) | Not applicable | Recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 450 | 2026-01-20 | 2026-06-23 |
| Better Communication, Better Care Using SICG Assistant Based on Artificial Intelligence Intervention Group - Cancer Care Providers | Not applicable | Active not recruiting | Cudeca Hospice Foundation | 190 | 2026-01-01 | 2026-08-07 |
| Inhaled Sedation in Critically Ill Patients Isoflurane, Propofol - Sedation, Airway Extubation | Phase 4 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 620 | 2025-12-15 | 2026-06-29 |
| Impact of Changing the Appearance of Oral Antineoplastics on Adherence and Continuity of Treatment, Patient-reported Health Outcomes, and Patient Experience of Care Adherence, Patient, Cancer | Recruiting | Universidad Miguel Hernandez de Elche | 334 | 2025-12-08 | 2026-06-24 | |
| NOPE37: Angiogenic Factors for Managing Term Preeclampsia Intervention arm: expectant management if sFlt-1/PlGF<38, Standard care: elective delivery at 37 weeks of gestation - Preeclampsia | Not applicable | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 750 | 2025-12-04 | 2025-12-11 |
| Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation Amiodarone Hydrochloride 200 MG, Amiodarone Hydrochloride 100 MG - Persistent Atrial Fibrillation | Phase 4 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 312 | 2025-11-01 | 2025-12-10 |
| Safety and Impact of Baricitinib on Cell Surivival Pathways, HIV-1 Reservoir and Inflamation in People With HIV-1 Bariticinib 2 mg, Placebo - HIV | Phase 2 | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 30 | 2025-09-22 | 2026-07-06 |
| Effectiveness, Implementation and Spillover Effects of a Culturally Adapted DPP in Spanish Primary Care Centers Adapted Diabetes Prevention Program, Usual Care - Prediabetes | Not applicable | Not yet recruiting | University of the Balearic Islands | 139 | 2025-09-01 | 2025-03-14 |
| NIMA-Colon Cancer Study Standard hypercaloric-hyperproteic nutritional supplementation, HMB-enriched hypercaloric-hyperproteic nutritional supplementation with vitamin D and calcium, Supervised exercise program - Colon Cancer | Not applicable | Recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 120 | 2025-07-01 | 2026-04-16 |
| Effectiveness and Cost-effectiveness of a Pre-emptive Genotyping Strategy in Patients Receiving Tacrolimus Tacrolimus - Kidney Disease, Chronic, Transplant Recipient (Kidney) | Phase 4 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 114 | 2025-06-02 | 2025-09-11 |
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Motor Activity (26) · Depression (17) · Diabetes Mellitus, Type 2 (14) · Obesity (14) · Inflammation (12) · COVID-19 (11) · Atherosclerosis (9) · Diabetes Mellitus (9) · Stroke (9) · Breast Neoplasms (8) · Heart Failure (8) · Cardiovascular Diseases (7) · Neoplasms (7) · Schizophrenia (7) · Sleep Apnea, Obstructive (7)
Exercise (5) · Continuous Positive Airway Pressure (4) · Control Groups (4) · Methods (4) · Primary Health Care (4) · Sodium Chloride (4) · Therapeutics (4) · Oxygen (3) · Physical Therapy Modalities (3) · Simvastatin (3) · Aripiprazole (2) · Aspirin (2) · Bevacizumab (2) · Blood Pressure Monitoring, Ambulatory (2) · Body Composition (2)
Spain (309) · Italy (3) · Belgium (2) · Canada (2) · Germany (2) · Netherlands (2) · Slovenia (2) · Sweden (2) · Argentina (1) · Austria (1) · Benin (1) · Brazil (1) · Ethiopia (1) · France (1) · Paraguay (1)
Bernardino Clavo, MD, PhD (5) · Milagros Rocha, PhD (3) · Anna Aulinas, MD PhD (2) · Cristina Paules (2) · Daniel Prados-Torres, MD, PhD (2) · Ferran Barbe, MD (2) · Javier Bermejo Thomas, MD, PhD (2) · Joaquin Duran-Cantolla, MD (2) · Jose A Serra, PhD (2)
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2018 (8), 2019 (5), 2009 (3), 2023 (2), 2025 (2), 2008 (1), 2014 (1), 2015 (1), 2016 (1)