6 recruiting, 2 completed, 1 enrolling by invitation, 1 terminated. 3 Phase 2, 2 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Recruiting 3 |
| Not applicable | 2 | Completed 2 |
| Phase 1 | 1 | Terminated 1 |
Follow Vascular Anomaly: new trials by email Literature Review of Vascular Anomaly trials Research Report on Vascular Anomaly
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 24VA022; VATCH Alpelisib for TIE2/PIK3CA Pathway VAs alpelisib (BYL719) - Vascular Anomalies, Vascular Anomaly | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 61 | 2025-08-27 | 2026-10-19 |
| 24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs Trametinib - Ras/MAPK Pathway Vascular Anomalies, Vascular Anomalies | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 45 | 2025-08-27 | 2026-10-19 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Vascular Anomaly Pathology and Genomics Biopsy Study Percutaneous Vascular Anomaly/Malformation Biopsy - Vascular Malformations, Vascular Anomaly | Not applicable | Completed | Mayo Clinic | 3 | 2021-04-06 | 2022-04-21 |
| Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions Topical Sirolimus - Vascular Anomaly | Phase 1 | Terminated | Nemours Children's Clinic | 5 | 2020-04-01 | 2025-12-31 |
| Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study Questionnaire - Vascular Anomaly, Osler Rendu Disease | Recruiting | Hospices Civils de Lyon | 400 | 2020-02-06 | 2026-09-28 | |
| A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Coronary Artery Disease, Myocarditis | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 2130 | 2019-12-12 | 2026-11-04 | |
| Efficacy and Safety of Sirolimus to Vascular Anomalies Sirolimus - Vascular Anomaly | Not applicable | Completed | West China Hospital | 126 | 2018-06-01 | 2022-03-15 |
| Identification of Biomarkers for Patients with Vascular Anomalies Vascular Anomaly, Generalized Lymphatic Anomaly | Recruiting | Children's Hospital Medical Center, Cincinnati | 1000 | 2015-04-01 | 2024-11-06 | |
| Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders NIRFLI with ICG - Lymphedema, Lymphatic Disorders | Enrolling by invitation | The University of Texas Health Science Center, Houston | 283 | 2009-01-01 | 2026-03-10 |
Vascular Malformations (10) · Arteriovenous Malformations (3) · Klippel-Trenaunay-Weber Syndrome (2) · Lymphatic Abnormalities (2) · Lymphedema (2) · Adiposis Dolorosa (1) · Aortic Valve Insufficiency (1) · Aortic Valve Stenosis (1) · Cardiomyopathy, Dilated (1) · Cardiomyopathy, Hypertrophic (1) · Central Nervous System Diseases (1) · Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi (1) · Coronary Artery Disease (1) · Heart Defects, Congenital (1) · Hemangioma (1)
Cardiovascular Abnormalities (10) · Cardiovascular Diseases (10) · Congenital Abnormalities (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Vascular Diseases (5) · Hemic and Lymphatic Diseases (4) · Genetic Diseases, Inborn (3) · Lymphatic Diseases (3) · Skin and Connective Tissue Diseases (3) · Angiomatosis (2) · Bone Diseases (2) · Bone Diseases, Developmental (2) · Connective Tissue Diseases (2) · Heart Diseases (2) · Musculoskeletal Diseases (2)
Alpelisib (2) · Sirolimus (2) · Indocyanine Green (1) · Surveys and Questionnaires (1) · mirdametinib (1) · trametinib (1)
Children's Hospital of Philadelphia (2) · Children's Hospital Medical Center, Cincinnati (1) · Hospices Civils de Lyon (1) · Mayo Clinic (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Murdoch Childrens Research Institute (1) · Nemours Children's Clinic (1) · The University of Texas Health Science Center, Houston (1) · West China Hospital (1)
United States (6) · Australia (1) · Canada (1) · China (1) · France (1)
Craig Johnson, DO (1) · David A Woodrum, MD, PhD (1) · Emily Bendel, MD (1) · Eva M Sevick, PhD (1) · Lydia Pathmanathan, MBBS, FRACP. (1) · Matthias G Friedrich, MD (1) · Stephen Luen, MBChB, FRACP. (1) · Timothy LeCras, PhD (1) · Tony Penington, MBBS, FRACS. (1) · Yi Ji (1)
R01CA128919 (1), R01HL092923 (1)