Ulcerative Colitis: Clinical Trials

573 completed, 191 unknown, 135 terminated, 120 recruiting. 274 Not applicable, 230 Phase 2, 157 Phase 3, 116 Phase 1, 81 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	274	Completed 123, Unknown 60, Recruiting 33, Terminated 26, Not yet recruiting 9, Active not recruiting 8, Withdrawn 8, Enrolling by invitation 4, Suspended 3
Phase 2	230	Completed 107, Terminated 44, Recruiting 26, Unknown 25, Active not recruiting 13, Withdrawn 13, Enrolling by invitation 2
Phase 3	157	Completed 93, Terminated 23, Unknown 14, Active not recruiting 11, Recruiting 10, Withdrawn 4, Enrolling by invitation 1, Not yet recruiting 1
Phase 1	116	Completed 70, Terminated 19, Unknown 14, Recruiting 5, Withdrawn 4, Active not recruiting 2, Enrolling by invitation 1, Not yet recruiting 1
Phase 4	81	Completed 39, Terminated 11, Recruiting 10, Unknown 9, Not yet recruiting 6, Withdrawn 4, Active not recruiting 2
Early Phase 1	12	Unknown 6, Terminated 2, Completed 1, Not yet recruiting 1, Recruiting 1, Withdrawn 1

Follow Ulcerative Colitis: new trials by email Literature Review of Ulcerative Colitis trials Research Report on Ulcerative Colitis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis High dose budesonide rectal foam, Low dose budesonide rectal foam, Matching placebo rectal foam - Ulcerative Colitis	Phase 4	Not yet recruiting	Bausch Health Americas, Inc.	100	2029-06-01	2026-10-06
ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease	Not applicable	Not yet recruiting	VA Office of Research and Development	50	2028-01-01	2026-02-09
Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease Digital Mind Body Intervention mobile application - Crohn's Disease, Ulcerative Colitis	Not applicable	Not yet recruiting	Montefiore Medical Center	40	2027-07-01	2026-09-14
Microbiome-targeted Diet Therapy in Ulcerative Colitis High Protein, High Fiber (HPHF) Diet - Ulcerative Colitis	Not applicable	Recruiting	University of Minnesota	40	2026-11-09	2026-10-20
Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis	Phase 4	Not yet recruiting	Jay C. Buckey Jr.	100	2026-11-01	2026-09-09
Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation Aquamin, Placebo - Ulcerative Colitis, Ileal Pouch	Phase 2	Recruiting	Muhammad N Aslam, MD	52	2026-11-01	2026-10-20
Development of the SC-IBD Self-Care Measurement Scale Inflammatory Bowel Diseases, Ulcerative Colitis		Not yet recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	275	2026-10-30	2026-09-21
Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease Inflammatory Bowel Disease, Crohn's Disease		Recruiting	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	100	2026-10-27	2026-10-22
Combination CurQD and Vedolizumab in Ulcerative Colitis CurQD, Placebo, Vedolizumab - Ulcerative Colitis	Phase 4	Not yet recruiting	Ryan C Ungaro	160	2026-10-01	2026-10-05
A Phase I, Randomized, Double-Blind, Placebo-Controlled Study of EQ504 in Single and Multiple Ascending Doses in Healthy Volunteers EQ504, EQ504 Placebo - Ulcerative Colitis	Phase 1	Not yet recruiting	Equillium	70	2026-10-01	2026-10-09
Early Changes in Inflammatory Indices and Healing in IBD Inflammatory Bowel Disease, Ulcerative Colitis		Not yet recruiting	Assiut University	138	2026-09-30	2026-10-02
A Study on Infections in Adults With Ulcerative Colitis/Crohn's Disease No intervention - Ulcerative Colitis, Crohn's Disease		Withdrawn	Takeda		2026-09-21	2026-10-15
Conventional vs Biologic Therapy in Pediatric IBD Inflammatory Bowel Diseases, Crohn Disease		Not yet recruiting	Assiut University	100	2026-09-10	2026-09-14
Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis Risankizumab, Trosunilimab, ABBV-701 - Crohn's Disease, Ulcerative Colitis	Phase 2	Recruiting	AbbVie	2000	2026-07-31	2026-10-20
Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease Digital self-management program, Standard Care - Inflammatory Bowel Diseases, Ulcerative Colitis	Not applicable	Recruiting	University of Michigan	40	2026-07-20	2026-07-23
Role of Bile Acids and Microbiota in Clostridioides Difficile Infection in Ulcerative Colitis Feces collection - Ulcerative Colitis		Recruiting	Assistance Publique - Hôpitaux de Paris	80	2026-06-09	2026-06-24
Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD SPY001, SPY002, SPY003 - Ulcerative Colitis, Inflammatory Bowel Diseases	Phase 2	Enrolling by invitation	Spyre Therapeutics, Inc.	645	2026-06-08	2026-10-19
Heart Rate Variability (HRV) Biofeedback to Treat Ulcerative Colitis HRV biofeedback - Ulcerative Colitis	Not applicable	Not yet recruiting	Icahn School of Medicine at Mount Sinai	23	2026-06-01	2026-03-13
Proof of Concept Study Evaluating the Efficacy and Safety of ATH-063 Treatment in Patients With Relapsed/Refractory Moderately to Severely Active Ulcerative Colitis (UC) ATH-063, Placebo - Ulcerative Colitis, Inflammatory Bowel Diseases	Phase 2	Recruiting	Athos Therapeutics Inc	120	2026-04-30	2026-09-21
A Study of Ozanimod in Pregnant Women With Ulcerative Colitis and Their Offspring Ulcerative Colitis		Recruiting	Bristol-Myers Squibb	1182	2026-04-21	2026-06-15

Showing 20 of 1157. Sign in to see all of them.

Narrower conditions

Colitis, Ulcerative (1157)  ·  Crohn Disease (380)  ·  Inflammatory Bowel Diseases (339)  ·  Colitis (32)  ·  Arthritis, Rheumatoid (29)  ·  Irritable Bowel Syndrome (25)  ·  Arthritis, Psoriatic (23)  ·  Spondylitis, Ankylosing (21)  ·  Psoriasis (18)  ·  Pouchitis (17)  ·  Depression (15)  ·  Anxiety Disorders (14)  ·  Multiple Sclerosis (14)  ·  Gastrointestinal Diseases (13)  ·  Autoimmune Diseases (12)

Broader conditions

Gastroenteritis (1154)  ·  Colonic Diseases (1150)  ·  Intestinal Diseases (1147)  ·  Digestive System Diseases (1146)  ·  Gastrointestinal Diseases (1144)  ·  Colitis (1125)  ·  Inflammatory Bowel Diseases (818)  ·  Pathological Conditions, Signs and Symptoms (89)  ·  Pathologic Processes (61)  ·  Immune System Diseases (52)  ·  Musculoskeletal Diseases (44)  ·  Skin and Connective Tissue Diseases (41)  ·  Joint Diseases (40)  ·  Bone Diseases (38)  ·  Skin Diseases (37)

Interventions

Mesalamine (62)  ·  Fecal Microbiota Transplantation (42)  ·  Infliximab (40)  ·  vedolizumab (38)  ·  Adalimumab (32)  ·  tofacitinib (17)  ·  mirikizumab (13)  ·  Blood Specimen Collection (11)  ·  Ustekinumab (11)  ·  Colonoscopy (10)  ·  Standard of Care (10)  ·  etrasimod (10)  ·  golimumab (10)  ·  ozanimod (10)  ·  etrolizumab (9)

Sponsors

Pfizer (27)  ·  AbbVie (24)  ·  Takeda (21)  ·  Ferring Pharmaceuticals (15)  ·  Bausch Health Americas, Inc. (14)  ·  Shire (13)  ·  Eli Lilly and Company (12)  ·  Bristol-Myers Squibb (11)  ·  Mayo Clinic (11)  ·  Assiut University (10)  ·  University of Erlangen-Nürnberg Medical School (10)  ·  Stanford University (9)  ·  Tanta University (9)  ·  Abivax S.A. (8)  ·  Chinese University of Hong Kong (8)

Countries

United States (422)  ·  Canada (175)  ·  Germany (152)  ·  France (150)  ·  Poland (144)  ·  United Kingdom (143)  ·  Italy (128)  ·  Belgium (125)  ·  Hungary (112)  ·  Czechia (107)  ·  Israel (104)  ·  Netherlands (101)  ·  Spain (100)  ·  South Korea (96)  ·  Australia (92)

Top investigators

Brian Feagan, MD (5)  ·  Arena CT.gov Administrator (4)

Results publications

PMID 40243391, PMID 35648151, PMID 36124702, PMID 29850873, PMID 30476584, PMID 31077827, PMID 31599001, PMID 32445184, PMID 32816215, PMID 33684552, PMID 35792493, PMID 36342120, PMID 36526796, PMID 36931693, PMID 38425446, PMID 39778975, PMID 26893500, PMID 32766762, PMID 32870265, PMID 33127596, PMID 33324993, PMID 33513294, PMID 34614208, PMID 35380664, PMID 35380740, PMID 36336750, PMID 37402275, PMID 37560161, PMID 38778549, PMID 42248437, PMID 16339095, PMID 19596014, PMID 25173754, PMID 26363929, PMID 26563167, PMID 28467869, PMID 29028981, PMID 29380251, PMID 29743836, PMID 34035832, PMID 34165201, PMID 36271912, PMID 36506749, PMID 37610533, PMID 38797892, PMID 39018016, PMID 39448057, PMID 39526078, PMID 40013523, PMID 17324131

NIH funding

2017 (20), 2023 (18), 2018 (11), 2015 (9), 2016 (7), 2014 (5), 2019 (5), 2025 (5), 2004 (3), 2008 (3), 2009 (3), P30CA060553 (2), 1IK2RD000689-01A2 (1), 1UL1RR025014-01 (1), 2005 (1)